KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition by Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert Blelloch

“…Summary: Mammalian genomes replicate in a cell-type-specific order during the S phase, correlated to transcriptional activity, histone modifications, and chromatin structure. The causal relationships between these features and DNA replication timing (RT), especially during cell fate changes, are largely unknown. …”
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The Burden of Smoking in the Health-Disease Process in People with Human Immunodeficiency Virus and AIDS by Yoenny Peña García, Luis Carlos Andraín Silva, Idalmis Sartorio Zayas, Dolys Suárez Padilla, Ana Julia Lozada Pérez

“…<br /><strong>Conclusion:</strong> there was a causal relationship between smoking and the immunodeficiency virus in addition to the incidence of Pneumocystis jirovecii pneumonia. …”
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Improving neuroendocrine tumor treatments with mathematical modeling: lessons from other endocrine cancers by John Metzcar, Rachael Guenter, Yafei Wang, Kimberly M Baker, Kate E Lines

“…Due to their relative rarity and lack of model systems, NETs and RETSs are difficult to study, hindering advancements in therapeutic development. Causal or mechanistic mathematical modeling is widely deployed in disease areas such as breast and prostate cancers, aiding the understanding of observations and streamlining in vitro and in vivo modeling efforts. …”
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Odontogenic Facial Cellulitis by Yordany Boza Mejias, Clotilde Mora Pérez, Julio Romero Rodríguez, Surelys Sosa Suárez, Madialys Payo Monzón, Arelys Díaz Duménico

“…The opening access was not performed to all the patients in the emergency service. The causal tooth extraction was not commonly done early, according to the prescribed antibiotic group. …”
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The determinants of life quality in African countries: Moderating role of CO2 emissions and health expenditures by Nazife Özge Beşer, Meral Çabaş, Süleyman Uğurlu, Cosimo Magazzino

“…Second, increases in health expenditures (HEALTH) and per capita income (GDP) significantly improve quality of life. Third, a strong causal relationship from health expenditures to quality of life emphasizes the importance of health investments. …”
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Diagnosis of Distal Cholangiocarcinoma after the Removal of Choledocholithiasis by Yasuhiro Ito, Takeshi Kenmochi, Tomohisa Egawa, Shinobu Hayashi, Atsushi Nagashima, Yuko Kitagawa

“…Distal cholangiocarcinoma associated with choledocholithiasis has not been reported, and the causal relationship remains to be established. We evaluated diagnosis of distal cholangiocarcinoma diagnosed after the removal of choledocholithiasis. …”
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Investigating the Efficacy of Topologically Derived Time Series for Flare Forecasting. I. Data Set Preparation by Thomas Williams, Christopher B. Prior, David MacTaggart

“…It is demonstrated that time-series signals, which correlate with flare onset times, also exhibit clear spatial correlations with eruptive activity, establishing a potential causal relationship. A significant database of helicity and winding fluxes and associated time series across 144 active regions is generated using Space-Weather HMI Active Region Patches data processed with the Active Region Topology (or ARTop) code that forms the basis of the time-series and spatial investigations conducted here. …”
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The evolutionary dynamics of plastic foraging and its ecological consequences: a resource-consumer model by Ledru, Léo, Garnier, Jimmy, Guillot, Océane, Faou, Erwan, Noûs, Camille, Ibanez, Sébastien

“…However, other disturbances such as persistent environmental change and increases in mortality, caused the evolutionary regression of the PF behaviour, due to its costs. The causal relationships between PF, community stability and diversity are therefore intricate, and their outcome depends on the nature of the environmental disturbance, in contrast to simpler models claiming a direct positive relationship between PF and stability. …”
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Multi-channel learning for integrating structural hierarchies into context-dependent molecular representation by Yue Wan, Jialu Wu, Tingjun Hou, Chang-Yu Hsieh, Xiaowei Jia

“…However, the data scarcity, combined with the highly non-linear causal relationships between physicochemical and biological properties and conventional molecular featurization schemes, complicates the development of robust molecular machine learning models. …”
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The effect of agency costs on the relationship between management characteristics and investment sensitivity to internal cash of companies listed on the Tehran Stock Exchange by Sedigheh Kamranrad, Seyed Hesam Vaghfi, Maliheh, Ghazvini

“…This research is a library and analytical-causal study based on panel data analysis; also, factor analysis was used to index CEO characteristics.Findings: The results showed that CEO optimism, ability, influence and experience have a significant effect on the sensitivities of firms' investment cash flows. …”
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Developing company competitiveness based on entrepreneurial values, transformational leadership, and service innovation through organizational performance by Solikin Solikin, Muhammad Thamrin, Suharto Abdul Majid, Librita Arifiani

“…The research uses a quantitative approach with survey methods and causal design. The sample was 153 leaders of ferry companies in Indonesia.The research instruments consist of organizational performance, competitiveness, entrepreneurial values, transformational leadership, and service innovation, as questionnaires were designed as a Likert scale. …”
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Comparison of Real-Time Methods Demonstrating the Effects of Reduced Glutathione on Olfactory Neuroblasts by Alain Géloën, Emmanuelle Berger

“…This is the first evidence of a causal link between GSH and changes in cell volume and motility required for cell division, migration, and/or differentiation. …”
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Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis by Chitprapassorn Thienvibul, Vasanop Vachiramon, Kumutnart Chanprapaph

“…Beta-lactams were the most common causal drug, particularly carbapenems and cephalosporins. …”
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Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity by Muyesser Sayki Arslan, Oya Topaloglu, Bekir Ucan, Melia Karakose, Basak Karbek, Esra Tutal, Mustafa Caliskan, Zeynep Ginis, Erman Cakal, Mustafa Sahin, Mustafa Ozbek, Tuncay Delibasi

“…Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto’s thyroiditis and NTIS.…”
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The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation by Barroso, Gustavo V, Dutheil, Julien Y

“…In doing so, our model captures the effects of genetic drift, linked selection and local mutation rates on patterns of genomic variation. We then formalize a causal model of how these micro-evolutionary mechanisms interact, and cast it as a linear regression to estimate their individual contributions to levels of diversity along the genome. …”
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The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study by Narges Radman, Michael Mouthon, Marie Di Pietro, Chrisovalandou Gaytanidis, Beatrice Leemann, Jubin Abutalebi, Jean-Marie Annoni

“…We further applied dynamic causal modelling (DCM) analyses to the connections between language and control brain areas. …”
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Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes by J. R. Thiele, J. Zeller, H. Bannasch, G. B. Stark, K. Peter, S. U. Eisenhardt

“…Here we review the current literature on the causal role of the dissociation mechanism of pCRP and the genesis of mCRP for the amplification of the proinflammatory potential in inflammatory reactions such as atherosclerosis and ischemia/reperfusion injury. …”
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Clinical Characteristics and Microorganisms Isolated in Community-Acquired Pneumonia in the COVID-19 Period by Meritxell Gavalda, Maria Isabel Fullana, Adrià Ferre, Rebecca Rowena Peña, Julen Armendariz, Orla Torrallardona, Aina Magraner, Alejandro Lorenzo, Carles García, Gemma Mut, Lluís Planas, Carla Iglesias, Pablo Fraile-Ribot, Maria Dolores Macia Romero, Melchor Riera, Mercedes García-Gasalla

“…Molecular tests are available for multiple pathogen detection and are under research to improve the causal diagnosis. Methods. We carried out a prospective study to describe the clinical characteristics and aetiology of community-acquired pneumonia during the COVID-19 pandemic and to assess the diagnostic effectivity of the microbiological tests, including a molecular test of respiratory pathogens (FilmArray™ bioMérieux). …”
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The Impact of Learner Ill-Discipline on Teaching and Learning in High Schools of Waterberg District, Limpopo Province by Mashaba Ernest Khalabai, Ntshengedzeni Albert Tshisevhe, Simeon Maile

“…This paper thus investigated the causal factors of learner ill-discipline at the school level with the intention to come up with practical measures that can be applied by the schools to curb learner indiscipline. …”
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Benefits of realist evaluation for rapidly changing health service delivery by Paula Kersten, Margaret Cupples, Rachel Thomas, Fiona Cramp, Nicola E Walsh, Justin Jagosh, Hannah Stott, Serena Halls, Cathy Liddiard, Dave Foster

“…These are: (1) ensuring that initial programme theories are developed through creative thinking sessions, empirical and non-empirical literature, and stakeholder consultation; (2) testing the causal impact of formal and informal (eg, emergent) components of service delivery models; (3) contrasting initial programme theories with rival theory statements; (4) envisioning broad system impacts beyond the immediate implementation setting; and (5) incorporating rapidly evolving service developments and context changes into the theory testing process in real-time (eg, Additional Role Reimbursement Scheme, COVID-19). …”
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