Exploring the causal role of plasma metabolites and metabolite ratios in prostate cancer: a two-sample Mendelian randomization study by Changzhou Feng, Haining Li, Chu Zhang, Ying Zhou, Huanhuan Zhang, Ping Zheng, Shaolin Zhao, Lei Wang, Jin Yang

“…Notably, NAG (OR 1.044; 95% CI 1.025–1.063) emerged as a metabolite with significant causal influence, as confirmed by stringent Bonferroni correction (P < 0.05/1400). …”
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Causally inferred evidence of the impact of green and blue spaces (GBS) on maternal and neonatal health: a systematic review and meta-analysis by Rukun K S Khalaf, Selin Akaraci, Faye D Baldwin, Rebecca S Geary, Ruwanthi Kolamunnage-Dona, Ruth F Hunter, Sarah E Rodgers

“…This does not allow for causal inference. Thus, our systematic review aimed to analyse the evidence of the impact of GBS on maternal, prenatal, and/or neonatal health. …”
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Exploring novelties in the causal relationship between economic complexity and natural resource rent: Empirical insights from Nigeria and South Africa by Clement Olalekan Olaniyi, Nicholas M. Odhiambo

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Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study by Bo-Ning Cao, Cai-Yan Zhang, Zhen Wang, Yao-Xian Wang, Yao-Xian Wang

“…We conducted a two-way Mendelian randomization (MR) analysis to explore the causal relationship between microbiota and diabetic nephropathy, followed by mediation analyses and two-step MR to identify potential blood metabolites.ResultsThere is a causal relationship between microbiota and diabetic nephropathy. …”
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Can Variation in Costs for Cardiovascular Procedures Be Attributed to Inefficiency in Care Delivery? Challenges in Causality, Data Availability, and the Need for Price Transparency by Waseem Nosair, MD, MPH, Morgana Mongraw-Chaffin, PhD, MPH, William S. Weintraub, MD

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Development and validation of a LAMP-based method for rapid and reliable detection of Xanthomonas albilineans, the causal agent of sugarcane leaf scald by Moutoshi Chakraborty, Moutoshi Chakraborty, Shamsul Arafin Bhuiyan, Shamsul Arafin Bhuiyan, Simon Strachan, Simon Strachan, Muhammad J. A. Shiddiky, Nam-Trung Nguyen, Rebecca Ford, Rebecca Ford

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Potential Functions and Causal Associations of GNLY in Primary Open-Angle Glaucoma: Integration of Blood-Derived Proteome, Transcriptome, and Experimental Verification by Wang D, Pu Y, Gao X, Zeng L, Li H

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Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study by Yunfan Tian, Mingxia Gu, Dazhong Chen, Quanbin Dong, Yifeng Wang, Wei Sun, Xiangqing Kong

“…However, these reports are often limited by weak causal evidence. This study investigates the potential causal association between gut microbiota and hypertension‐related traits using Mendelian randomization with summary data from genome‐wide association studies. …”
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Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis by Cheng Z, Wu J, Xu C, Yan X

“…Univariable MR investigated the causal relationship between frailty and COPD. Genetic correlation was assessed using linkage disequilibrium score (LDSC) regression. …”
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Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality by Kang Wu, Qiming Gan, Yuhong Pi, Yanjuan Wu, Wenjin Zou, Xiaofen Su, Sun Zhang, Xinni Wang, Xinchun Li, Nuofu Zhang

“…Abstract Background Obstructive sleep apnea (OSA) is linked to brain alterations, but the specific regions affected and the causal associations between these changes remain unclear. …”
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Report on emerging foliar soft rot disease on ginseng Panax vietnamensis and the identification of Neocosmospora ipomoeae and Fusarium miscanthi as the causal pathogens by Hau T. Duong, Duong T. Pham, Van T. Pham, Anh H. Le, Toi D. Nguyen, Nam X. Nguyen, Chung T. Khuat, Hang T. Dinh

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Container Freight Rates and International Trade Causality Nexus: Evidence from Panel VAR Approach for Shanghai and ASEAN-6 Countries by Xingong Ding, Mengzhen Wang

“…Container shipping drives the development of international trade, yet previous studies have not fully appreciated the possible bidirectional causal relationship between container freight rates and international trade. …”
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Causal association among smoking, bitter beverage consumption, and risk of osteoporosis: a two-sample mendelian randomization-based study by Yanqian Wu, Jianqian Chao, Min Bao, Na Zhang, Leixia Wang

“…Results Smoking per day was causally associated with the risk of osteoporosis OR = 1.417, 95% CI = 1.119–1.794, P = 0.003), and lifetime smoking index had a possible genetic causal association with the risk of osteoporosis with pathological fractures (OR = 4.187, 95% CI = 1.909–9.184, P < 0.001). …”
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Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis by Ding X, Bai Z, Wang W, Gu Y, Li Z, Fan Y

“…Reverse MR analysis found no causal effect of AGA on FI (P=0.808, OR=1.0001). A total of 92 FI-associated genes were analyzed, with enrichment results indicating involvement in glycine, serine, and threonine metabolic pathways. …”
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The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study by Tao Zhong, Yu-qing Huang, Guiming Wang

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Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms by Chunge Cao, Xiaorui Sun, Xiaohu Chen, Ying Zhang, Chaoyan Yue

“…We aimed to evaluate the causal relationship between IBD and uterine cervical neoplasm using a bidirectional Mendelian randomization analysis.MethodsWe derived instrumental variables for IBD, including Crohn’s disease and ulcerative colitis, from the IEU Open genome-wide association study (GWAS) database, and for the histological subtypes of uterine cervical neoplasm from the FinnGen repository’s GWAS data. …”
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A Novel Hyper-Heuristic Algorithm with Soft and Hard Constraints for Causal Discovery Using a Linear Structural Equation Model by Yinglong Dang, Xiaoguang Gao, Zidong Wang

Subjects: “…causal discovery…”
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Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble by James A. Casaletto, Ryan T. Scott, Makenna Myrick, Graham Mackintosh, Hamed Chok, Amanda Saravia-Butler, Adrienne Hoarfrost, Jonathan M. Galazka, Lauren M. Sanders, Sylvain V. Costes

“…In this work, we use a machine learning ensemble of causal inference methods called the Causal Research and Inference Search Platform (CRISP) which was developed to predict causal features of a binary response variable from high-dimensional input. …”
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Determinants of traditional Korean medicine utilization by individuals with physical disabilities: inference of causal relationships using Korea health panel data by Chihyoung Son, Jong-hyun Kim, Eunkyung Yoon, Eunji Ahn, Minjung Park, Dongsu Kim

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Causal associations between osteoporosis and HBV infection across Asian and European populations: evidence from Mendelian randomization and colocalization analysis by Zhengnan Li, Jiarui Cao, Ke Li, Yixin Wu, Zhanpeng Luo, Rui Cao, Zhiheng Cheng, Zhendong Tian, Yiyang Han, Yuping Lai, Bangqi Wang, Shen Chen

“…IntroductionClinical studies have demonstrated a potential association between chronic hepatitis caused by hepatitis B virus (HBV) infection and osteoporosis. However, the causal relationship between HBV infection and osteoporosis remains to be determined.MethodsWe investigated whether HBV infection is causally associated with osteoporosis using Mendelian randomization (MR) in East Asian and European populations, respectively. …”
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