Causality between insulin use and malignant tumors of the digestive system: a two-sample mendelian randomized study by DengZhuo Chen, YongLi Ma, JingHui Li, Liang Wen, GuoSheng Zhang, ChengZhi Huang, XueQing Yao

“…This study uses two-sample Mendelian randomization (MR) to further investigate the causal relationship between the two. Methods We selected single nucleotide polymorphisms (SNPs) strongly associated with insulin use as instrumental variables and used aggregated statistics on digestive system neoplasms as the outcome event. …”
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CAUSAL RELATIONSHIP AMONGST CORPORATE LONG-TERM FINANCING DECISIONS: EMPIRICAL EVIDENCE OF LISTED NIGERIAN MANUFACTURING FIRMS by Jeremiah Babajide OPALEKE

“…To make the study eclectic, Agency theory of corporate and financial management and the Panel Granger’s causality model were adopted as the study’s theoretical frameworks. …”
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Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer by Zhao Sicheng, Zhao Sicheng, Zhang Jingcheng, Zhang Jingcheng, Zhang Shuo, Zhang Shuo, Lou Jiaheng, Lou Jiaheng, Cai Yan, Cai Yan, Bai Xing, Bai Xing, Jiang Tao, Jiang Tao, Jiang Tao, Zhang Guangji, Zhang Guangji, Zhang Guangji

“…ObjectiveGastric cancer is a harmful disease, the comorbidity mechanism and causality relationship between this disease and other diseases are worth studying.MethodsUsing a two-sample Mendelian Randomization method, this study revealed the potential causal effect of atrial fibrillation (AF) on gastric cancer (GC) risk by constructing a genetic instrument containing 136 AF associated SNPs. …”
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Exploring the causal impact of body mass index on metabolic biomarkers and cholelithiasis risk: a Mendelian randomization analysis by Feng Zhao, Yanjiang Yang, Wenwen Yang

“…Using Mendelian randomization (MR) analysis, we examined the causal relationship between BMI, 249 metabolic traits, and cholelithiasis. …”
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Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study by Qian Ge, Zhongyan Li, Weijing Meng, Chen Cai, Mengdi Qiu, Yafei Liu, Haibo Zhu

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Investigating causal relationships between plasma proteins and lung adenocarcinoma: result from proteomics and Mendelian randomization study by Ruoya Lv, Jiabin Chen, Xiaoyu Wu, Kequn Chai, Jiadong Yan, Sheng Wang

“…Then, the DEPPs were subjected to a two-sample Mendelian randomization (MR) study based on an “Inverse variance weighted (IVW)” approach to investigate the causal relationships between DEPPs and LUAD. Logistic regression analysis was conducted to develop a diagnostic model for LUAD. …”
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Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study by Che L, Zang H, Bi Y, Wen B, Xu L

“…We conducted the causal estimates using the inverse variance-weighted method (IVW), with sensitivity analyses using MR-Egger, weighted median, weighted mode, and MR pleiotropy residual sum and outlier (MR-PRESSO) analysis. …”
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Causal Relationships Between Blood Lipid Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis by Huang P, Zhao Y, Wei H, Wu W, Guo Z, Ma S, Xu M, Wang Q, Jia C, Xiang T, Li H

“…Sensitivity analysis demonstrated the robustness of these causal relationships. However, through multivariate MR(MVMR) and multiple testing correction, LDL-C and TG had no causal effect on the outcome. …”
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Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study by Wen-Hao Hu, Jia-An Sun, Chang Liu

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Mycovirome of Diaporthe helianthi and D. gulyae, causal agents of Phomopsis stem canker of sunflower (Helianthus annuus L.) by Chien-Fu Wu, Elizabeth Regedanz, Febina Mathew, Ruchika Kashyap, Karthika Mohan, Shin-Yi Lee Marzano

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Evaluating the synergy: anxiety prevalence and alcohol consumption patterns in high-income countries using Granger causality analysis by Binguni Senarathne, Dinithi Palliyaguru, Anne Oshini, Janudi Gamage, Ruwan Jayathilaka, Lochana Rajamanthri, Colinie Wickramarachchi

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Gene signatures derived from transcriptomic-causal networks stratify colorectal cancer patients for effective targeted therapy by Akram Yazdani, Heinz-Josef Lenz, Gianluigi Pillonetto, Raul Mendez-Giraldez, Azam Yazdani, Hanna Sanoff, Reza Hadi, Esmat Samiei, Alan P. Venook, Mark J. Ratain, Naim Rashid, Benjamin G. Vincent, Xueping Qu, Yujia Wen, Michael Kosorok, William F. Symmans, John Paul Y. C. Shen, Michael S. Lee, Scott Kopetz, Andrew B. Nixon, Monica M. Bertagnolli, Charles M. Perou, Federico Innocenti

“…Abstract Background Gene signatures derived from transcriptomic-causal networks offer potential for tailoring clinical care in cancer treatment by identifying predictive and prognostic biomarkers. …”
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Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study by Wei Du, Biqiu Tang, Senhao Liu, Wenjing Zhang, Su Lui

“…Abstract Despite observational studies linking brain iron levels to psychiatric disorders, the exact causal relationship remains poorly understood. This study aims to examine the relationship between iron levels in specific subcortical brain regions and the risk of psychiatric disorders. …”
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Causal relationship between matrix metalloproteinase and pulmonary embolism: a bidirectional two-sample Mendelian randomization study by Xiaowei Gong, Yadong Yuan

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The Causal Relationship of the Feature Personality Traits Following Mediation Therapy Perceived Social Support in Female Cancer Patients by Maryam Mardani, Manijeh Firoozi, Tina Vosoughi

“…The present study aimed to investigate the causal relationship between personality traits and treatment adherence, as well as the mediating role of social support in female cancer patients.Method: The research method employed was descriptive, and the research design utilized correlational structural equation modeling (SEM). …”
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A Single Lung Transplant in a Patient with Fabry Disease: Causality or Far-Fetched? A Case Report by Martina Gaggl, Renate Kain, Peter Jaksch, Dominik Haider, Gerald Mundigler, Till Voigtländer, Raute Sunder-Plassmann, Paulus Rommer, Walter Klepetko, Gere Sunder-Plassmann

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Application of Mendelian randomization analysis to explore causal associations of aspirin use with bone mineral density and risk of fracture by Qi-Pei Liu

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Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota by Jianwei Wu, Jing Zhang, Gang Huang, Yinglian Zhong, Yi Yang, Peng Deng

“…Hence, this study endeavors to investigate whether a causal relationship exists between gut microbiota and pMN utilizing Mendelian randomization (MR) analysis.Methods The primary method employed for MR analysis is the inverse variance weighting method, supplemented by MR-Egger and the weighted median method, to infer causality. …”
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Causal association of sex hormone-related traits with Alzheimer’s disease: a multivariable and network Mendelian randomization analysis by Yan Zhang, Zhen-dong Sun, Yu-shen Yang, Wei-dong Fu

“…Importantly, testosterone plays a mediating role in the causal pathway from SHBG to females AD.…”
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Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study by Liaoyi Lin, Yingbao Huang, Songzan Qian, Lifang Chen, Houzhang Sun

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