Methimazole disrupted skeletal ossification and muscle fiber transition in Bufo gargarizans larvae by Fei Wei, Xueyi Wu, Hongyuan Wang, Yongpu Zhang, Lei Xie

“…., BMPs, MMPs, and Wnt9a) in cartilage, thereby delaying chondrocyte apoptosis and inhibiting hindlimb ossification. …”
Get full text

Surgical Treatment Options for the Young and Active Middle-Aged Patient with Glenohumeral Arthritis by Sanjeev Bhatia, Andrew Hsu, Emery C. Lin, Peter Chalmers, Michael Ellman, Brian J. Cole, Nikhil N. Verma

“…Patients with lower functional demands and smaller lesions are best suited for simpler, lower morbidity palliative procedures such as debridement (chondroplasty) and cartilage reparative techniques (microfracture). Those with higher functional demands and large glenohumeral defects will usually benefit more from restorative techniques including autograft or allograft osteochondral transfers and autologous chondrocyte implantation (ACI). …”
Get full text

A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…These applications include early and precise diagnosis of MMP activity via fluorescence probe technologies; acting as nanodrug carriers to enable on-demand drug release triggered by pathological microenvironments; and facilitating cartilage engineering through MMP-mediated degradation, which promotes cell migration, matrix synthesis, and tissue integration. …”
Get full text

Similarities and Differences between Clavicular Bacterial Osteomyelitis and Nonbacterial Osteitis: Comparisons of 327 Reported Cases by Nan Jiang, Ping Zhang, Wei-ran Hu, Zi-long Yao, Bin Yu

Get full text

Clinical Guidelines for Acupotomy Treatment of Knee Osteoarthritis by Working Group of Acupotomy Medical Branch of China Association of Chinese Medicine, XIU Zhongbiao, CHEN Changxian, ZHANG Jianxin, LV Yanan, WEI Song, ZHOU Yu, WAN Quanqing, ZENG Weiquan, CHEN Guoqiang, HUANG Huirong, CAI Zhaolian, YAN Guohong, ZHAI Hongye, LIN Huayang, LIU Hong, ZHANG Liangzhi

“…Knee osteoarthritis is a chronic degenerative disease characterised by degeneration of articular cartilage, secondary bone formation, subchondral bone sclerosis and synovial inflammation, it belongs to the category of "Xibi" in Chinese medicine. …”
Get full text

Increased global posterior tibial slope is significantly associated with higher ACL graft signal intensity on 2-Year postoperative MRI after primary ACL reconstruction using hamstr... by Zhi-yu Zhang, Le-jin Hong, Wen-bin Bai, Jia-yi Shao, Yi-tian Gao, Xiao-yue Fu, Jian-quan Wang, Cheng Wang

“…Results Multivariable analyses showed that increased global PTS (GPTS) (P = 0.008) and concomitant articular cartilage injuries (P = 0.005) were associated with higher average signal intensity of the ACL graft on two-year postoperative MRI, while preoperative internal rotational tibial subluxation (IRTS) calculated as the difference between lateral ATS and medial ATS did not show a significant association. …”
Get full text

Patellofemoral mechanics after uniplane open wedge high tibial osteotomy is superior to those after biplane open wedge high tibial osteotomy by Yi Zheng, Bin Yang, Decheng Meng, Zhijie Wang, Naihao Pan, Chen Feng, Juan Wang

“…Conclusion Uniplane OWHTO would induce lower contact stress and larger contact area on the patellofemoral surface than biplane OWHTO during walking and sitting-to-standing, which may cause less mechanical pain and secondary damage to the articular cartilage. Therefore, uniplane OWHTO might be a better option for patients with anterior knee pain and/or PFJ degeneration.…”
Get full text

Surgical treatment of fourth branchial apparatus anomalies: a case series study by Wan-Xin Li, Yanbo Dong, Aobo Zhang, Jun Tian, Cheng Lu, Jean Pierre Jeannon, Liangfa Liu

“…The tracts were all followed to the vicinity of inferior cornu of the thyroid cartilage and the cricothyroid space. Complete resection of cervical lesions and their attachment to hypopharynx were achieved in 9 cases. …”
Get full text

A ten-year evaluation of central nervous system cystic echinococcosis in a highly endemic area of Iran: Molecular epidemiology and clinicopathological characteristics by Mohsen Najjari, Ali Dehesht Manesh, Shahab Rezaeian, Bibi Razieh Hosseini Farrash, Mohammad Ali Mohammadi, Mohammad Ebrahimipour

“…Spine infections included bone cartilage, ligaments, and hydatid cyst wall fragments. …”
Get full text

Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential by Rushikesh Girase, Nayan A. Gujarathi, Amey Sukhia, Sri Sai Nikitha Kota, Tulshidas S. Patil, Abhijeet A. Aher, Yogeeta O. Agrawal, Shreesh Ojha, Charu Sharma, Sameer N. Goyal

“…Rheumatoid arthritis (RA) is an inflammatory immune-triggered disease that causes synovitis, cartilage degradation, and joint injury. In nanotechnology, conventional liposomes were extensively investigated for RA. …”
Get full text

Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…Results from various studies demonstrate that liposomal DEX significantly inhibits arthritis progression in animal models, reduces joint inflammation and damage, and alleviates cartilage destruction compared to free DEX. The liposomal formulation also shows better hemocompatibility, fewer adverse effects on body weight and immune organ index, and a longer circulation time with higher bioavailability. …”
Get full text

Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…In vivo therapeutic investigation suggested that MCDs reduced synovial inflammation and hyperplasia, ultimately prevented cartilage destruction, bone erosion, and synovial fibrosis in CIA rats. …”
Get full text

Impaired fracture healing is associated with callus chondro-osseous junction abnormalities in periostin-null and osteopontin-null mice by Marc Teitelbaum, Marc Teitelbaum, Maya D. Culbertson, Charlene Wetterstrand, J. Patrick O’Connor, J. Patrick O’Connor

“…The dysmorphic chondro-osseous junctions in the PostnHET, PostnKO, and Spp1KO calluses were associated with reduced numbers of MMP-13 expressing hypertrophic chondrocytes, consistent with delayed cartilage resolution. Unlike collagen X expressing callus chondrocytes, chondrocytes only expressed MMP-13 when localized to the chondro-osseous junction or after traversing the chondro-osseous junction. …”
Get full text

Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle> by Qi Xu, Xiao-hui Xu, Ze-zheng Liu, Jian-bi Zhu, Huan-huan Ding, Chun-chun Jin, Zhi-han Yan

“…The ablated synovial tissue initially presented as a white mass, which subsequently liquefied into a milky white viscous fluid. Gross articular cartilage was observed, along with liquefied necrosis of the synovium on pathological histology and infiltration of inflammatory cells in the surrounding soft tissue.Conclusion The experimental results demonstrated that ultrasound-guided RFA of the knee in the treatment of synovial hyperplasia in AIA model animals was both effective and safe.…”
Get full text

The effect of cheese intake on osteoarthritis: a Mendelian randomization study by Song Wen, Zehan Huang, Bin Zhang, Yuqing Huang

“…Introduction Osteoarthritis (OA) is a debilitating chronic disease with a high prevalence, characterized by progressive degeneration of articular cartilage that leads to joint dysfunction, pain, and disability. …”
Get full text

Intraoperatively identified patellofemoral osteoarthritis: no significant impact on short-term outcomes of medial unicompartmental knee arthroplasty by Bei Li, Changyu Huang, Bingqian Zheng, Zida Huang, Xinyu Fang, Xiaoyong Wang, Wenming Zhang

“…Patellofemoral joint cartilage damage was assessed using the Outerbridge classification. …”
Get full text

Forensic-medical determination of the severity of closed injuries of the hyoid-laryngeal complex according to the data of a specialized clinic by M.V. Gubin, V.O. Olkhovskyi, G.I. Garyuk, V.M. Gubin

“…Injuries in 8 (12.9%) patients were assessed as injuries of medium severity, mainly in cases of laryngeal cartilage fractures due to the lack of danger to life. …”
Get full text

Exploring the immunohistochemical profile of basosquamous carcinoma and its clinicopathological associations by Cemile Tuğba Altunel, Gonca Özgün, Arzu Karataş, Özlem Özen, Deniz Seçkin, Tülin Güleç, Deren Özcan

“…Ulceration rate and margin positivity were 70.2% and 22.1%, respectively. The cartilage, muscle, lymphovascular, and perineural invasion prevalences were 3.8%, 11.5%, 5.8%, and 5.8%, respectively. …”
Get full text

Enhanced effects of slowly co-released TGF-β3 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects by Jiping Chen, Yanyi Wang, Tianyi Tang, Baochao Li, Banani Kundu, Subhas C. Kundu, Rui L. Reis, Xingnan Lin, Huang Li

“…The SFI-T/SFI-B scaffolds could improve cartilage and bone regeneration in 5 × 4 mm rabbit osteochondral (OC) defect. …”
Get full text

The Effects on Knee Swelling, Range of Motion and Pain using a Commercially Available Hot/Cold Contrast Device in a Rehabilitation and Sports Medicine Setting by Kevin E Wilk, Robert E Mangine, James Tersakjs, Kimberly Hasselford

“…Subjects presented with various types of knee pain, both non-operative and operative, secondary to ligamentous, tendinous, cartilage, muscle, and/or meniscus pathology. The subjects were in various stages of rehabilitation with six in the acute stage, 24 in subacute stage, and 20 in the chronic stage. …”
Get full text