Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study usi... by Tommy Kok Annfeldt, Elisabeth Ginnerup-Nielsen, Eva Elisabeth Wæhrens, Lene Vase, Lars Erik Kristensen, Tanja Schjødt Jørgensen

“…Osteoarthritis and Cartilage Open…”
Get full text

Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies by Jacinta Cheng, Tia Solomon, Mahnuma Estee, Flavia M. Cicuttini, Yuan Z. Lim

“…Osteoarthritis and Cartilage Open…”
Get full text

Study on the protective effect of naringin-regulated lncRNA GAS5 against mitochondrial apoptosis in osteoarthritic chondrocytes by LIN Qin, ZHU Yingkai, LIN Yanming, LAN Shujie, CHEN Changxing, FU Changlong

“…Magnetic resonance imaging and ultrasound were used to identify the success of modeling; histopathological changes in rat articular cartilage were assessed using toluidine blue and saffron O staining; changes in the levels of lncRNA GAS5 in rat cartilage tissues after naringin intervention were detected by Real-time PCR; Western blot detected Caspase-3, Bax, MMP-13 and Cyt-C in rat cartilage tissues. …”
Get full text

Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes by Jie Shi, Jiulong Liang, Bingyu Guo, Yu Zhang, Qiang Hui, Peng Chang, Kai Tao

“…Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. …”
Get full text

Effects of Yanghe Decoction on IL-1 and TNF-α of Papain in Rabbit Knee Osteoarthritis by Zhenqiang HONG, Hongjian GAO, Junjun HE, Zeling HUANG

“…One week after drug withdrawal, all experimental animals were sacrificed, and the rabbit femoral medial condyle articular cartilage was taken. The morphological changes of articular cartilage stained with hematoxylin-eosin were further observed by naked eye and light microscope, and the degree of cartilage degeneration was evaluated by modified Mankin's score standard. …”
Get full text

Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants by Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt

“…Abstract Objective To explore IL11 co-expression profiles in our previously reported RNA-sequencing dataset of OA articular cartilage, in interaction with IL6, and to investigate the effects of hrIL11 administration as potential therapeutic strategy for OA articular cartilage using our biomimetic aged human osteochondral explant model of OA. …”
Get full text

Progress in Study of Low-Intensity Pulsed Ultrasound Acting on Inflammation-Related Signaling Pathways in Knee Osteoarthritis by OUYANG Hui, LIN Xingjin, WANG Jinying, SHEN Longbin, WANG Chengdong

“…Knee osteoarthritis (KOA) is a degenerative total joint disease involving pathological changes in the cartilage, synovium, subchondral bone, and periarticular ligaments and muscles of the joint. …”
Get full text

Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study by Joonas Sirola, Anna-Kaisa Koistinen, Kari Salovaara, Toni Rikkonen, Marjo Tuppurainen, Jukka S. Jurvelin, Risto Honkanen, Esko Alhava, Heikki Kröger

Get full text

Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a by Yuchuan Zhou, Tian Zheng, Lin Li, Yangfang Guo, Jiayu Xiao, Jin Wang, Zhiqin Du, Hui Gao, Weiwei Tang, Liusan Yang, Haiyan Hu, Xiaodan Wang, Mingyao Meng, Zongliu Hou

“…Based on their chondrogenic differentiation ability, mesenchymal stem cell- (MSC-) based cartilage regeneration is a promising approach for cartilage defect repair. …”
Get full text

DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone by Lei Ding, Joseph A. Buckwalter, James A. Martin

“…Injured cartilage-conditioned culturing medium containing a mixture of DAMPs was employed as a control. …”
Get full text

YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints by Tuija Väänänen, Anna Koskinen, Erja-Leena Paukkeri, Mari Hämäläinen, Teemu Moilanen, Eeva Moilanen, Katriina Vuolteenaho

“…The present study introduces YKL-40 as a cartilage-derived factor associated with mediators of inflammation and cartilage destruction involved in the pathogenesis of OA.…”
Get full text

A single-cell 3D dynamic volume control system for chondrocytes by Qiang Zhang, Yiyao Wang, Yanjun Zhang, Xiaochun Wei, Weiyi Chen, Quanyou Zhang

“…In articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA). …”
Get full text

Establishment and Evaluation of a Moderate-to-Severe Knee Osteoarthritis Model in Rats Induced by Surgery by SUN Xiaorong, SU Dan, GUI Wenjuan, CHEN Yue

“…Imaging examinations reveal osteophytes, osteoporosis, and loose bodies in the knee joints, while pathological observations show a reduction or even disappearance of joint cartilage, with a disruption in the balance of cartilage anabolic and catabolic metabolism.…”
Get full text

Effects of different microfracture drilling parameters on bone quality: a finite element analysis by Jiayi Luo, Jiayi Luo, Zihao Zou, Qiang Zou, Qiang Zou, Siwei Luo, Jialin He, Chuan Ye, Chuan Ye

“…BackgroundMicrofracture drilling is a surgical technique that involves creating multiple perforations in areas of cartilage defects to recruit stem cells from the bone marrow, thereby promoting cartilage regeneration in the knee joint. …”
Get full text

Self‐Healing Hyaluronic Acid‐based Hydrogel with miRNA140‐5p Loaded MON‐PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self‐Assembly Approach by Wei Zhu, Han Wang, Bin Feng, Guangli Liu, Yixin Bian, Tianhao Zhao, Qi Wang, Xisheng Weng

“…Abstract Articular cartilage defects present a significant therapeutic challenge due to the inherent avascular and aneural characteristics of cartilage tissue. …”
Get full text

Herbal remedies as a potential alternative therapy for arthritis by Disha Trivedi, Riya Jayapal Roja, Eva Künnemann

“…These are marked by specific molecular patterns and immunological pathways that lead to chondrolysis and destruction of cartilage. Natural plant substances can influence these pathways and help to break out of the vicious cycle and to find a way for stopping the disease or even to regenerate and heal injured cartilage. …”
Get full text

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy by Ronaldo J. F. C. do Amaral, Henrique V. Almeida, Daniel J. Kelly, Fergal J. O’Brien, Cathal J. Kearney

“…The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. …”
Get full text

Exploring the Analgesic Effect of Acupuncture on Knee Osteoarthritis Based on MLT/cAMP/PKA/CREB Signaling Pathway by Zhang C, Yu M, Zhang L, Zhou X, Han J, Fu B, Xue H, Zhang C

“…The pathological alterations of cartilage tissue were observed using hematoxylin and eosin (H&E) staining, Safranin O-fast green and MASSON staining to observe the pathological changes in cartilage tissue, and the efficacy was evaluated according to the principles of Mankin score and Osteoarthritis Research Society International (OARSI) score. …”
Get full text

Effect of Electroacupuncture on Chondrocyte Apoptosis in Knee Osteoarthritis Rat Based on PI3K/Akt Signaling Pathway by Yuanyuan ZHANG, Xinyu JIANG, Xihai LI, Mingxia WU

“…The degree of cartilage degeneration was evaluated by modified Mankin's scoring standard. …”
Get full text

Acute Traumatic Injury of the Larynx by K. O. Kragha

“…Two case histories are presented: (1) case history A: a 53-year-old male, after motor vehicle accident, fractured the mid anterior thyroid cartilage and both aspects of the cricoid cartilage; however, this patient was asymptomatic from the above fractures; and (2) case history B: a 41-year-old male who sustained trauma to the chest, neck, and left arm after being struck by a large lead pipe which fractured the left aspect of the cricoid cartilage was symptomatic. …”
Get full text