Respiratory and Rehabilitation Expert Consensus on Full-cycle Rehabilitation Assessment and Treatment for Elderly Patients with Chronic Obstructive Pulmonary Disease by CHEN Xin, JIA Jie, DING Yipeng, YE Xujun, DONG Anqin, HE Jing, LIAO Weijing, ZHENG Jieqiao, YU Binbin, CHEN Zuobing, FANG Yuan, YAO Liqing, ZHU Yiping, FU Jianghong, WANG Siyuan, ZHANG Yangxian

“…It recommends a comprehensive assessment of elderly COPD patients' multifaceted impairments based on the International Classification of Functioning, Disability, and Health (ICF) framework, covering four aspects：body structure, body function (respiratory function, cardiac function, exercise function, psychological and cognitive function, swallowing function, and nutritional factors), activity and participation, and environmental factors. …”
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Unsupervised machine learning model for phenogroup-based stratification in acute type A aortic dissection to identify postoperative acute gastrointestinal injury by Yuhu Ma, Xiaofang Yang, Chenxiang Weng, Xiaoqing Wang, Baoping Zhang, Ying Liu, Rui Wang, Zhenxing Bao, Peining Yang, Hong Zhang, Yatao Liu

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Real-world treatment patterns of patients with acute coronary syndrome based on 15-year data by Inga S. Egorova, Natalia N. Vezikova

“…Life-threatening complications occurred in 1 out of 3 patients with STEACS and 1 out of 7 patients with NSTE-ACS. Cardiac arrest (p 0.0001), myocardial rupture (p=0.001), arrhythmias (p 0.0001), and cardiogenic shock (p 0.0001) were significantly more common in patients with STEACS, and pulmonary edema (p=0.005) was significantly more common in patients with NSTE-ACS. …”
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Impact of Postshock Transcutaneous Pacing on Chest Compression Quality during Resuscitation: A Simulation-Based Pilot Study by Wojciech Telec, Tomasz Kłosiewicz, Radosław Zalewski, Julia Żukowska-Karolak, Artur Baszko, Mateusz Puślecki

“…Participants were asked to take part in a 10-minute adult cardiac arrest scenario with ventricular fibrillation. …”
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CHA2DS2-VASc Score Is Associated With Prognosis in Patients With Acute Ischemic Stroke Without Atrial Fibrillation by Mingjuan Song, MM, Xu Chen, MD

“…The primary outcome was major adverse cardiac events (MACE) at 1 year after index AIS. Multivariate Cox regression analyses evaluated the prognostic value of CHA2DS2-VASc scores after controlling for potential confounding factors. …”
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Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors by Nivaldo de Jesus Silva Soares Junior, Carlan Senna, Carlos Alberto Alves Dias-Filho, Bruno Rodrigues, Maria Claudia Irigoyen, Danielle da Silva Dias, Vinícius Santos Mendes, Carlos José Moraes Dias, Sally Cristina Moutinho Monteiro, Cristiano Teixeira Mostarda

“…Objective: To analyze the influence of the level of physical activity and the polymorphism in the ACE gene on cardiac autonomic modulation and the chance of cardiovascular risk in adolescents. …”
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Etiology and Prognosis of Cardiogenic Shock in a Secondary Center without Surgical Back-Up by Laurent Bonello, Marc Laine, Etienne Puymirat, Victoria Ceccaldi, Mélanie Gaubert, Franck Paganelli, Pr Franck Thuny, Thibaut Dabry, Guillaume Schurtz, Clement Delmas, Julien Mancini, Gilles Lemesle

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Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes by Kristen N. Andersen, Sicong Yao, Brian R. White, Marin Jacobwitz, Jake Breimann, Jharna Jahnavi, Alexander Schmidt, Wesley B. Baker, Tiffany S. Ko, J. William Gaynor, Arastoo Vossough, Rui Xiao, Daniel J. Licht, Evelyn K. Shih

“…Methods and Results One hundred ninety‐two infants with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass were evaluated with pre‐ (n=183) and/or postoperative (n=162) magnetic resonance imaging. …”
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Impact of Arterial Remodeling of Intermediate Coronary Lesions on Long-Term Clinical Outcomes in Patients with Stable Coronary Artery Disease: An Intravascular Ultrasound Study by Liang Geng, Peizhao Du, Yuan Yuan, Liming Gao, Yunkai Wang, Jiming Li, Qi Zhang

“…The primary endpoint was the composite vessel-oriented clinical events, defined as the composition of target vessel-related cardiac death, target vessel-related myocardial infarction, and target vessel revascularization. …”
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Comparative safety of transvenous and leadless pacemakers in patients with cardiovascular diseases: A meta-analysis study by Cedric Mhasseb, Mayassa Kiwan, Marie-Elie Merhi, Nicolas Moussallem, Jana Moussalli, Maroun Abou Zeid, Sarah Abou Daher, Ghassan Nabbout, Sami Azar, Amjad Kanaan, Frederic Harb

“…However, higher odds of cardiac perforation and tamponade and thromboembolic events were observed among patients receiving LP. …”
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A platform for Bioengineering Tissue Membranes from cell spheroids by Quang Bach Le, Hariharan Ezhilarasu, Weng Wan Chan, Alok Tanala Patra, Priya Murugan, Shashaank Abhinav Venkatesh, Yean Kai Tay, Shin Ru Lim, Ahmad Amirul Abdul Rahim, Jia Sheng Zach Lee, Xuezhi Bi, Deepak Choudhury

“…Cell spheroids are essential building blocks for engineering tissues like cartilage, bone, liver, cardiac, pancreatic, and neural tissues, but controlling their fusion and organisation is challenging. …”
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Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates by Mengping Liu, Erica Cook, Yanshan Dai, Erich Ehlert, Francois du Plessis, Jacek Lubelski, Bogdan G. Sleczka, Petia Shipkova, Zhuyin Li, Joshua Gamse, David Gordon, Leonard P. Adam, Paul C. Levesque, Glen B. Banks

“…AAV8 led to higher levels of microdystrophin-FLAG mRNA and protein in the cardiac ventricles and skeletal muscles when compared to AAV5 or AAV9. …”
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The role of sacubitril/valsartan in abnormal renal function patients combined with heart failure: a meta-analysis and systematic analysis by Xinyue Yang, Jingjing Jin, Meijuan Cheng, Jinsheng Xu, Yaling Bai

“…As for safety outcomes, we did not find that the rate of hyperkalemia (OR:1.31, 95%CI:0.79–2.17) and hypotension (OR:1.57, 95%CI:0.94–2.62) were increased in sacubitril/valsartan group among CKD stages 3–5 patients with heart failure.Conclusions Our meta-analysis proves that sacubitril/valsartan has a favorable effect on cardiac function without obvious risk of adverse events in abnormal renal function patients combined with heart failure, indicating that sacubitril/valsartan has the potential to become perspective treatment for these patients.…”
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Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID by Andrea Polli, Lode Godderis, Dries S. Martens, Madhura Shekhar Patil, Jolien Hendrix, Arne Wyns, Jente Van Campenhout, Emma Richter, Lara Fanning, Olivia Vandekerckhove, Eveline Claeys, Wim Janssens, Natalie Lorent

“…Different clinical presentations can be identified. Cardiac involvement (as measured by troponin T levels) and telomere shortening might be a relevant risk factor for developing PEM-fatigue symptoms and deserve further exploring.…”
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Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…Secondary endpoints include neuropsychologic outcomes at 12 months of age, seizure frequency, cardiac and cerebral tumor load, and safety assessments. …”
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Global, regional and national burdens of cardiovascular disease attributable to secondhand smoke from 1990–2019: an age-period-cohort analysis by Hong Jiang, Xiang-Bin Pan, Xiaofei Li, Shouzheng Wang, Zeye Liu, Peijian Wei, Fengwen Zhang, Wen-Bin Ou-yang

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Predictors and Prognostic Effects of Perioperative Myocardial Injury After Transcatheter Aortic Valve Replacement According to VARC-3 Criteria by Hu X, Zhao Z, Wang C, Feng D, Chen Y, Niu G, Zhou Z, Zhang H, Li Z, Ye Y, Wang M, Wu Y

“…PPMI was defined according to the VARC-3 criteria as a 70-fold increase of upper reference limit in cardiac troponin I (cTnI) levels. We compared the baseline characteristics, perioperative conditions, and in-hospital and long-term endpoints between the PPMI and non-PPMI groups. …”
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The Australian and New Zealand Fontan Registry Quality of Life Study: Protocol for a population-based assessment of quality of life among people with a Fontan circulation, their pa... by Daniel S J Costa, Kim Dalziel, Yves d’Udekem, David S Winlaw, David S Celermajer, Nadine A Kasparian, Diana Zannino, Rachel Bishop, Kate H Marshall, Susan R Woolfenden, Gary F Sholler

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Association of coronary revascularisation after physician-referred non-invasive diagnostic imaging tests with outcomes in patients with suspected coronary artery disease: a post ho... by Takao Kato, Moriaki Inoko, Naoya Matsumoto, Yukari Uemura, Masanao Naya, Mitsuru Momose, Satoshi Hida, Takao Yamauchi, Takatomo Nakajima, Eriko Suzuki, Tohru Shiga, Nagara Tamaki

“…We assessed the effect of revascularisation (within 90 days) in each diagnostic imaging stratum and the interaction between the two strata.Primary and secondary outcome measures Major adverse cardiac events (MACEs), including death, myocardial infarction, hospitalisation for heart failure and late revascularisation, were followed up for 1 year. …”
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A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression by Xiaohan Su, Yunbo Luo, Yali Wang, Peng Qu, Jun Liu, Shiqi Han, Cui Ma, Shishan Deng, Qi Liang, Xiaowei Qi, Panke Cheng, Lingmi Hou

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