Loss of protein C vs protein S results in discrepant thrombotic phenotypes by Chia-Jui Ku, Xinge Yu, Queena Y. Zhao, Steven J. Grzegorski, Jeffrey G. Daniel, Allison C. Ferguson, Jordan A. Shavit

“…Although both mutants demonstrated spontaneous thrombosis, proc−/− was localized to the cardiac and venous systems, whereas pros1−/− was intracardiac. …”
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Outcome of Very Late Relapse in Patients with Hodgkin's Lymphomas by Francesco Gaudio, Annamaria Giordano, Vincenzo Pavone, Tommasina Perrone, Paola Curci, Domenico Pastore, Mario Delia, Clara de' Risi, Alessandro Spina, Vincenzo Liso, Giorgina Specchia

“…At a median of 4 years after therapy for very late relapse, 10 pts (63%) are still alive and free of disease and 6 (37%) died (1 from progressive HL, 1 from cardiac disease, 1 from thromboembolic disease, 1 from HCV reactivation, and 2 from bacterial infection). …”
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An In Vitro Pilot Study Comparing the Novel HemoClear Gravity-Driven Microfiltration Cell Salvage System with the Conventional Centrifugal XTRA™ Autotransfusion Device by Anneloes Hoetink, Sabine F. Scherphof, Frederik J. Mooi, Paul Westers, Jack van Dijk, Sjef J. van de Leur, Arno P. Nierich

“…We evaluated its performance in the cardiac postoperative setting compared to the centrifugal XTRA™ autotransfusion device. …”
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Protocol for a meta-review of interventions to prevent and manage ICU delirium by Andrew Booth, Maria Pufulete, Ben Gibbison, Burak Kundakci, Katherine Louise Jones

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GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial by Minh Tam Le, Dac Nguyen Nguyen, Jessica Zolton, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Alan Decherney, Micah J. Hill

“…A clinical pregnancy was defined as the presence of gestational sac with fetal cardiac activity. There was no difference in ovulation rates in either group receiving GnRHa or hCG trigger for ovulation. …”
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Application of Handheld Tele-ECG for Health Care Delivery in Rural India by Meenu Singh, Amit Agarwal, Vineet Sinha, Rohit Manoj Kumar, Nishant Jaiswal, Ishita Jindal, Pankaj Pant, Munish Kumar

“…The objective of our study was clinical validation of handheld tele-ECG as a screening tool for evaluation of cardiac diseases in the rural population. ECG was obtained in 450 individuals (mean age 31.49 ± 20.058) residing in the periphery of Chandigarh, India, from April 2011 to March 2013, using the handheld tele-ECG machine. …”
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Nanobody-thioesterase chimeras to specifically target protein palmitoylation by Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller

“…Using a thioesterase fused to a nanobody directed against the Ca(v)1.2 beta subunit we reduce palmitoylation of the Ca(v)1.2 alpha subunit, modifying the channel’s voltage dependence and arrhythmia susceptibility in stem cell derived cardiac myocytes. We conclude that nanobody enzyme chimeras represent an approach to specifically manipulate PTMs, with applications in both the laboratory and the clinic.…”
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Prevalence of immunological aberrations and 22q11.2 deletion in children with conotruncal anomalies: A cross-sectional study by Souvik Das, Arun Kumar Baranwal, Amit Rawat, Ashwini Nair, Sanjeev Hanumantacharya Naganur, Anupriya Kaur, Anand Kumar Mishra, Ankur Jindal, Anit Kaur

“…Patients with asplenia and polysplenia were excluded from immunological studies. Results: Major cardiac defects ([n = 101], [median age, 32 days]) included dextro-transposition of great arteries (d-TGA) - 41.6%, tetralogy of Fallot - 37.6%, double outlet right ventricle (DORV) - 13.9%, and truncus arteriosus - 4.9%. …”
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Deaths during Sexual Activity by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…The perforation led to complications, including purulent diffuse peritonitis, intoxication, and acute cardiac and respiratory failure, resulting in death within 3-6 hours after insertion. …”
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Association of non-selective β blockers with the development of renal dysfunction in liver cirrhosis: a systematic review and meta-analysis by Xiangbo Xu, Fangbo Gao, Ting Wang, Zuyao Yang, Qingchun Zhao, Xingshun Qi

“…Background & Aims Non-selective β blockers (NSBBs) may negatively influence renal function through decreasing heart rate and cardiac output. This study aimed to systematically investigate their association.Methods PubMed, EMBASE, and Cochrane library databases were searched to identify all relevant studies evaluating the association of NSBBs with renal dysfunction in cirrhotic patients. …”
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Myocardial Perfusion Scintigraphy in Ischemic Heart Disease by Sonia María Sánchez Valcarcel, Katia Ravelo Llanes, Iván Rodríguez Cortina, Geovedy Martínez García, Cesia Rivera Garmendia

“…The fall in the post-stress left ventricular ejection fraction behaved as a predictive variable of future cardiac events.…”
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Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial by Matthias Behrends, Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Aaron J Clark, Jacqueline M Leung

“…Introduction Postoperative delirium is a frequent adverse event following elective non-cardiac surgery. The occurrence of delirium increases the risk of functional impairment, placement to facilities other than home after discharge, cognitive impairment at discharge, as well as in-hospital and possibly long-term mortality. …”
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Clinical and Prognostic Significance of Idiopathic Left Bundle-Branch Block in Young Adults by Pietro Delise, Luigi Rivetti, Giuseppe Poletti, Monica Centa, Giuseppe Allocca, Nadir Sitta, Arianna Cati, Giovanni Turiano, Emanuela Lanari, Paolo Zeppilli, Luigi Sciarra

“…Thirty patients underwent cardiac magnetic resonance; in 60% it was normal, while in 40% it revealed late enhancement, which in 33% was localized in the basal septum, suggesting fibrosis of the left bundle branch. …”
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Mesothelioma in Two Nondomestic Felids: North American Cougar (Felis concolor) and Cheetah (Acinonyx jubatus) by Amanda Whiton, Juergen Schumacher, Erika E. Evans, Janelle M. Novak, Amanda Crews, Edward Ramsay, Robert Donnell

“…During attempts to remove the fluid, cardiac tamponade developed and the cat died. At necropsy, nodular masses decorated the pericardium at the level of the base of the heart. …”
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Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction by Elizabeth J. Wright, Nigel W. Hodson, Michael J. Sherratt, Moustapha Kassem, Andrew L. Lewis, Christine Wallrapp, Nadim Malik, Cathy M. Holt

“…We examined the effects of MSCs, either native, or engineered to secrete a GLP-1 fusion protein (MSCs ± GLP-1), on human cardiomyocyte apoptosis in vitro. The effect on cardiac remodeling when encapsulated in alginate beads (CellBeads-MSC and CellBeads-MSC + GLP-1) was also evaluated in a pig MI model, whereby pigs were treated with Empty Beads, CellBeads-MSC, or CellBeads-MSC + GLP-1 and sacrificed at one or four weeks following MI. …”
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Generation and characterization of the LINC01405 knockout human embryonic stem cell line by Yaping Xu, Hongchun Wu, Jingxiu Jiang, Lingqun Ye, Kaili Hao, Kunjun Han, Shijun Hu, Wei Lei, Zhikun Guo

“…This cell line will be an invaluable model for the research on LINC01405's role in normal development of cardiac and skeletal muscle, and their diseases.…”
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Comparisons between chest trunk mobilization with sustained maximum inspiration and flow incentive spirometry on chest expansion, respiratory muscle strength, and functional exerci... by Khanistha Wattanananont, Sasipa Buranapuntalug, Sira Laohathai

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Role of Terlipressin in Cirrhotic Patients with Ascites and without Hepatorenal Syndrome: A Systematic Review of Current Evidence by Zhaohui Bai, Yang An, Xiaozhong Guo, Rolf Teschke, Nahum Méndez-Sánchez, Hongyu Li, Xingshun Qi

“…In 3 studies (1 randomized controlled trial and 2 single-arm studies without controls) involving 32 patients who received terlipressin for nonrefractory ascites, terlipressin improved hemodynamics by decreasing the heart rate and cardiac output and increasing the mean arterial pressure and systemic vascular resistance. …”
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Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtili... by Berick Moturi Sieberi, George Isanda Omwenga, Rachael Kitondo Wambua, Judith Chemutai Samoei, Mathew Piero Ngugi

“…Phytochemical screening of the DCM-MeOH extract revealed the presence of alkaloids, flavonoids, phenolics, terpenoids, cardiac glycosides, saponins, steroids, and tannins. …”
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Impact of Body Mass Index on Short-Term Outcomes in Patients Undergoing Percutaneous Coronary Intervention in Newfoundland and Labrador, Canada by Anne B. Gregory, Kendra K. Lester, Deborah M. Gregory, Laurie K. Twells, William K. Midodzi, Neil J. Pearce

“…Patients with obesity were younger and had a higher incidence of diabetes, hypertension, and family history of cardiac disease. Obese patients experienced less vascular complications (normal, overweight, and obese: 8.2%, 7.2%, and 5.3%, p=0.001). …”
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