Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats by Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano

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Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging by Zhang Y, Liu F, Shao C, Huang J, Yan G

“…The contrast-enhanced fluorescent imaging has been applied for non-invasive diagnosis of cancers using tumor-targeting fluorescent probes.Methods: The carbonic anhydrase IX targeted polyaspartamide fluorescent compounds (SD-PHEA-NI) were synthesized by incorporating a tumor-targeting group of sulfadiazine (SD) and N-butyl-4-ethyldiamino-1,8-naphthalimide (NI) into water-soluble carriersof poly-α,β-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA). …”
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Synthesis and Evaluation of New Phthalazine Urea and Thiourea Derivatives as Carbonic Anhydrase Inhibitors by Nurcan Berber, Mustafa Arslan, Emre Yavuz, Cigdem Bilen, Nahit Gencer

“…A new series of phthalazine substituted urea and thiourea derivatives were synthesized, and their inhibitory effects on the activity of purified human carbonic anhydrases (hCAs I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative (1) was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and nitro group was reduced to amine derivative (2) with SnCl2·2H2O. …”
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Highly Active Carbonic Anhydrase of the Thylakoid Lumen of <i>Chlamydomonas reinhardtii</i> by Vasily V. Terentyev, Liubov I. Trubitsina, Anna K. Shukshina, Ivan V. Trubitsin, Natalia N. Rudenko

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Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator by Peng Ma, Jie Xiao, Biyu Hou, Ping He, Xinyu Yang, Yisa Wang, Zijing Wang, Tianshu Xu, Xiuying Yang, Xuan Zhu, Shasha Xiang, Song Li, Guanhua Du, Jian Ying, Guifen Qiang

“…Specifically, utilizing in silico approach of network pharmacology and molecular docking, we identified carbonic anhydrase 2 (CA2) in nitrogen metabolism as anti-obesity target of BTE and further elucidated that protein kinase B (AKT) signaling pathway linked CA2 and UCP1. …”
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Validated LC Method for the Estimation of Dorzolamide HCl (Carbonic Anhydrase Inhibitor) in Ophthalmic Solutions by A. Narendra, D. Deepika, M. Mathrusri Annapurna

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Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview by Katia D’Ambrosio, Anna Di Fiore, Emma Langella

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Screening of a Novel Peptide Targeting the Proteoglycan-Like Region of Human Carbonic Anhydrase IX by Shoaib Rana, Felix Nissen, Thomas Lindner, Annette Altmann, Walter Mier, Juergen Debus, Uwe Haberkorn, Vasileios Askoxylakis

“…The extracellular domain of human carbonic anhydrase IX (CA IX) is extended by a proteoglycan-like region (PGLR). …”
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Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy by Özgen Arslan Solmaz, Nizamettin Kutluer, Mehmet Buğra Bozan

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Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

“…Here we show T cells can be armored with membrane-bound cytokines with surface expression regulated using drug-responsive domains (DRDs) developed from the 260-amino acid protein human carbonic anhydrase 2 (CA2). The CA2-DRD can be stabilized in vitro and in vivo with the FDA-approved small-molecule CA2 inhibitor acetazolamide (ACZ). …”
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Expression and localization of two β-carbonic anhydrases in Bienertia, a single-cell C4 plant by Tho Nguyen, Nakyoung Lee, Fabian J. Frömling, Toni L. Meister, Toni L. Meister, Toni L. Meister, Jung Sun Kim, Sascha Offermann, Inhwan Hwang

Subjects: “…β-carbonic anhydrases…”
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The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide by Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Valeria A. Panova, Julia A. Efimova, Sergey A. Ivanovskiy, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov

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Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure by Chengeng Liu, Yue Wei, Jianmin Wang, Langan Pi, Jianjun Huang, Peichang Wang

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Inhibitory Effect of Human Anti-CA I Autoantibodies and Development of Monoclonal Antibody mAb 2B8 Targeting Carbonic Anhydrase I by Petra Chalova, Barbora Jankovicova, Veronika Dvorakova, Eliska Zelinkova, Zuzana Bilkova, Marcela Slovakova, Lucie Korecka, Petr Muller, Maksym Danchenko, Lenka Minichova, Jan Lakota, Ludovit Skultety

“…Recent research emphasizes the alterations in autoantibodies against carbonic anhydrase I (CA I) (anti-CA I) levels as potential prognostic markers for various malignancies. …”
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Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents by Tulika Anthwal, Swati Pant, Preeti Rana, Sumitra Nain

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CARP VIII antibody-related autoimmune cerebellar ataxia in a child after Mycoplasma pneumoniae infection: a case report by Minglei Li, Zongming Han, Jinlei Li, Qianyun Wang, Zufang Lv

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Exploring the Potential of Selenium-Containing Amine (Se-AMA) to Enhance Photosynthesis and Leaf Water Content: New Avenues for Carbonic Anhydrase Modulation in <i>Arabidopsis thaliana</i> by Sara Beltrami, Francesca Alderotti, Antonella Capperucci, Damiano Tanini, Cecilia Brunetti, Francesco Ferrini, Ermes Lo Piccolo, Antonella Gori

“…Global changes and growing demands have led to the development of new molecular approaches to improve crop physiological performances. Carbonic anhydrase (CA) enzymes, ubiquitous across various life kingdoms, stand out for their critical roles in plant photosynthesis and water relations. …”
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The evaluation of pharmacokinetic parameters of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide and its metabolites in rat plasma by Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov, Alena N. Tyushina, Olga E. Lasaryanz

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Comparing standard treatment of moderate to severe obstructive sleep apnoea to add-on acetazolamide treatment: An open-label randomised controlled trial by Anurag Tripathi, Ved Prakash, Hemant Kumar, Mohammad Arif, Atul Tiwari, Sachin Kumar, Mrityunjaya Singh, Deepak Sharma, Shubhra Srivastava

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Biotechnology in direct air capture, enhanced weathering, and methane removal: emerging opportunities and gaps by Paul L. Reginato

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