Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion by Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn

“…In C. elegans, the BMP2/4 ortholog DBL-1 regulates multiple biological functions, including body size, via a canonical receptor-Smad signaling cascade. Here, we identify functional binding sites for SMA-3/Smad and its transcriptional partner SMA-9/Schnurri based on ChIP-seq peaks (identified by modEncode) and expression differences of nearby genes identified from RNA-seq analysis of corresponding mutants. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Genomic alterations were subdivided into canonical oncogenic pathways and noted for their involvement in homologous recombination deficiency (HRD). …”
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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

“…Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. …”
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Unraveling TGF-β1’s Role in Mediating Fibrosis and Cell Death in Feline Kidney Cells by Chanyanuch Intachat, Phongsakorn Chuammitri, Benjaporn Sornpet, Prapas Patchanee, Nawin Manachai, Kakanang Piyarungsri

“…TGF-β1 signaling through the non-canonical/smad-independent pathway activates mitogen-activated protein kinase (MAPK) signaling, which is linked to fibrosis and apoptosis. …”
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Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates by Panagiotis N. Lalagkas, Rachel D. Melamed

“…Then, we use a network approach to link these shared genes to canonical pathways. Similarly, for all drugs treating the predisposing disease, we link their targets to pathways. …”
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Trellis Decoding for Qudit Stabilizer Codes and Its Application to Qubit Topological Codes by Eric Sabo, Arun B. Aloshious, Kenneth R. Brown

“…Here, we improve the scalability and practicality of their theory, show that it has strong structure, extend the results using classical coding theory as a guide, and demonstrate a canonical form from which the structural properties of the decoding graph may be computed. …”
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Farmers’ desire to make changes in their agricultural branches in the first wave of COVID-19 pandemic restrictions: The example of Türkiye by Yener Ataseven, Şule Coşkun Cevher, Celal Cevher

“…A survey study was conducted with broad participation and telephone interviews involving 2125 farmers in different production branches in 22 provinces. Nonlinear Canonical Correlation Analysis was used to analyze variables. …”
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Extensive composable entropy for the analysis of cosmological data by Constantino Tsallis, Henrik Jeldtoft Jensen

“…Being extensive means that in the micro-canonical, or uniform, ensemble where all micro-state occur with the same probability, the entropy becomes proportional to N asymptotically: S(N)∝N for N→∞. …”
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The Stanley Parable : le joueur contre le narrateur by Douglas Hoare

“…À l’instar des films de la Nouvelle Vague, le jeu de Galactic Cafe parodie les codes et les canons de l’industrie et va jusqu’à les déconstruire pour proposer une expérience singulière de jeu. …”
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Deconstrucţia canonului literar în critica actuală română şi sârbă by Mariana Dan

“…This leads to the conclusion that critics like Negrici, while trying to demistify the canons of Romanian literature, involve in a new process of myth-formation, which is not in favour of Romanian literature.…”
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Ethnocultural Landscape of Medieval Mausoleums in the Volga-Urals by Ivanov V.A.

“…In this regard, the following tasks were laid out: To show that the Keshene Bendebike and the “Tower of Tamerlane” belong to a large group of so-called. steppe brick mausoleums built in the steppes of the Volga and Southern Urals according to the canons of the Central Asian architectural school. …”
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Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms by Zhengjie Shen, Yongjuan Gu, Ruiyang Jiang, Heya Qian, Siyuan Li, Lixian Xu, Wenzhe Gu, Yun Zuo

“…Our previous study found that T96 could inhibit TNBC invasion via suppressing the canonical and noncanonical TGF-β signaling pathways. …”
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Association of a non-synonymous substitution in the condensin NCAPG gene with traits of eggs in laying hens by O. Yu. Barkova, M. G. Smaragdov

“…The results obtained are discussed in connection with the role of the canonical condensin complex in the compaction of chromatin and segregation of chromosomes.…”
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Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension by Jéssica Moraes Cruvinel, Elizabeth S. Greene, Rachel W. Read, Kichoon Lee, Sami Dridi, Paula R. Chen

“…Culture at 1% O2 resulted in increased abundance of HIF1α, a canonical protein stabilized during hypoxia, thus confirming effectiveness of the treatment. …”
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From physical activity patterns to cognitive status: development and validation of novel digital biomarkers for cognitive assessment in older adults by Ling-Jie Fan, Feng-Yi Wang, Jun-Han Zhao, Jun-Jie Zhang, Yang-An Li, Jia Tang, Tao Lin, Quan Wei

“…Demographic characteristics were also incorporated, and multimodal data fusion was achieved through canonical correlation analysis. We then developed explainable machine learning models, primarily random forest, optimized with hyperparameters, to predict individual cognitive function status. …”
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Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…However, sustainable feedstocks pose a challenge due to incomplete high-resolution metabolic data for non-canonical carbon sources required to curate GSMM and identify implementable designs. …”
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Mapping the Discourse. Architecture Periodicals in/for the Teaching of Architecture History by Gaia Caramellino, Valeria Casali, Nicole De Togni

“…On the one hand, the cross-reading of “journal biographies” and the study of the “anatomy” of diverse genres of magazines contribute to question canonical interpretations and timeframes of a 20th century architectural history still centered on the European and North American editorial scene, offering a more nuanced understanding of the times and forms of production of architectural culture. …”
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Constelações pós-utópicas: sobre a poesia de Haroldo de Campos by Diana Junkes Bueno Martha

“…Si se ve desde la relación con el canon, el trabajo creativo de Haroldo de Campos va más allá de lo concreto, lo que sugiere la existencia de un vínculo entre la utopía vanguardista y un sentido más amplio centrado en el diálogo y la reinvención de la tradición, a lo que se le puede llamar la utopía fáustica y que pueden estar asociado con la post-utopía, presentada por el poeta en Poesia e modernidade, da morte do verso à constelação, o poema pós-utópico. …”
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A Survey and Comparison the Amount of Important Pollutants in the Exhaust of Light Gasoline Vehicles Referring to the Technical Inspection Centers in Urban Areas: A Case Study in I... by Abbas Khodabakhshi, Moluk Hadi Alijanvand, Fazel Mohammadi-Moghadam, Abdullah Mutauligalleh kolaie, Soghra Ebrahimi

“…The audit analysis, which involved a linear combination of O2, CO, CO2, HC, and vehicle age, successfully differentiated between cars in Shahrekord and Rasht, yielding a correct prediction rate of 81.3% (Wilks’ Lambda statistic = 0.687, Eigen value = 0.455, Canonical correlation value = 0.60 with a P < 0.0001). …”
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X-ray emission from hot gas and XRBs in the NGC 5846 galaxy by Kyadampure Anil, Vagshette Nilkanth, Patil Madhav

“…Among 90, only one source exhibits an X-ray luminosity greater than 1039ergs−11{0}^{39}\hspace{0.33em}{\rm{erg}}\hspace{0.33em}{{\rm{s}}}^{-1}, exceeding the Eddington limit for a canonical mass of a neutron star and occupies a position in the hard region of the X-ray color–color plot. …”
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