In silico drug repurposing at the cytoplasmic surface of human aquaporin 1. by Aled R Lloyd, Karl Austin-Muttitt, Jonathan G L Mullins

“…A complete model of human AQP1 based on its canonical sequence was assembled using I-TASSER and MODELLER. …”
Get full text

Assessment of Formalin-Fixed Bovine Larynx Asymmetry Using Geometric Morphometry by Arcesio Salamanca-Carreño, Pere M. Parés-Casanova, Mauricio Vélez-Terranova, Néstor Ismael Monroy-Ochoa

“…Asymmetry between sexes was assessed by means of a Canonical Variate Analysis on regression residuals of asymmetric components using the Mahalanobis distance, which assumes a lack of isotropy. …”
Get full text

SLC35A2 gene product modulates paramyxovirus fusion events during infection. by Yanling Yang, Yuchen Wang, Danielle E Campbell, Heng-Wei Lee, Wandy Beatty, Leran Wang, Megan Baldridge, Carolina B López

“…Our findings demonstrate that paramyxoviruses can bind to or enter A549 cells in the absence of canonical galactose-bound sialic-acid decorations and show that UGT facilitates paramyxovirus fusion processes involved in entry and spread.…”
Get full text

Ecological drift during colonization drives within-host and between-host heterogeneity in an animal-associated symbiont. by Jason Z Chen, Zeeyong Kwong, Nicole M Gerardo, Nic M Vega

“…Specialized host-microbe symbioses canonically show greater diversity than expected from simple models, both at the population level and within individual hosts. …”
Get full text

Method for synthesizing a logic element that implements several functions simultaneously by S. I. Sovetov, S. F. Tyurin

“…The basic element of a field-programmable gate array is a lookup table (LUT). While in canonical normal form LUTs generally implement only one logical function for a given configuration, in this case, there is always an inactive pass transistor element. …”
Get full text

Thioflavin-T: application as a neuronal body and nucleolar stain and the blue light photo enhancement effect by Jin-Hong Min, Heela Sarlus, Sho Oasa, Robert A. Harris

“…In this study we expand the use of THT beyond its canonical usage for staining amyloid plaques and demonstrate its novel use as an easy and rapid stain comparable to fluorescent Nissl staining, allowing for clear discernment of neuronal cell bodies and also nucleoli in fixed tissue and live cells. …”
Get full text

Management of asynchronous multifocal adult glioblastoma with loss of BRAFV600E -mutant clonality: a case report by Hannah Haile, Pavan S. Upadhyayula, Esma Karlovich, Michael B. Sisti, Brian J. A. Gill, Laura E. Donovan

“…Abstract Glioblastoma (GBM) classification involves a combination of histological and molecular signatures including IDH1/2 mutation, TERT promoter mutation, and EGFR amplification. Non-canonical mutations such as BRAFV600E, found in 1–2% of GBMs, activate the MEK-ERK signaling pathway. …”
Get full text

Japanese Popular Culture and Digimodernism by N. B. Afanasov

“…The article refers to the genesis of Japanese popular culture in the mid-90s of the XX century, when the most popular part of Japanese pop culture in the West — anime — embodied the postmodern canon. However, a closer look reveals that the optics of postmodernism, which by the end of the XX century had already ceased to be advanced research optics, may not be enough for analysis. …”
Get full text

Resonant analogue configurations in atomic condensates by Muñoz de Nova, Juan Ramón, Fernández Palacios, Pablo, Alcázar Guerrero, Pedro , Zapata, Ivar, Sols, Fernando

“…We perform a detailed study of the thermality of the Andreev and Hawking spectra for canonical black-hole solutions, finding that both can be described by a gray-body distribution to a very good approximation. …”
Get full text

Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
Get full text

Mechanically Twisting‐Induced Top‐Down Chirality Transfer for Tunable Full‐Color Circularly Polarized Luminescent Fibers by Xiaoxiao Yu, Linfeng Chen, Qin Liu, Xiaoqing Liu, Zhenduo Qiu, Xinhai Zhang, Meifang Zhu, Yanhua Cheng

“…Although previous investigations have shown that external force fields can induce CPL activity in nonchiral systems, the unique role of macroscopic external forces in inducing CPL has not been demonstrated at the level of molecule or molecular aggregate. Here, a canonical example of CPL generation by mechanical twisting in an achiral system consisting of a polymer matrix with embedded fluorescent molecules is presented. …”
Get full text

Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization by Danyue Li, Weilv Xu, Suhui He, Xinyue Li, Yumeng Wang, Qian Lv, Nan Chen, Lu Dong, Feng Guo, Fushan Shi

“…In this study, SCU demonstrated efficacy in hindering pyroptosis mediated by the NOD-like receptor protein 3 (NLRP3) inflammasome, absent in melanoma 2 (AIM2) inflammasome, NLR-family CARD-containing protein 4 (NLRC4) inflammasome, and that activated through the non-canonical pathway. The inhibitory effect is achieved by thwarting apoptosis-associated speck-like protein containing CARD (ASC) oligomerization and inducing the ubiquitin-dependent selective autophagy of p30/GSDMD. …”
Get full text

Investigating the Lower Limit of Metallicity for the Galactic Thin Disk by Guozhen Hu, Zhengyi Shao, Erbil Gügercinoǧlu, Wenyuan Cui

“…A comparative analysis of the HP-MPTnD sample with other Galactic components revealed its chemo-dynamical similarities with canonical thin disk stars. These low- α metal-poor stars are predominantly located in the outer disk region and formed in the early stage of the formation of thin disk. …”
Get full text

Alteridades persistentes by Jorge Tomasi, Julieta Barada

“…Las otredades arquitectónicas han sido un campo fecundo para la comprensión de las particularidades de las sociedades más lejanas al mundo occidental y sus cánones disciplinares. En este artículo se explorará el modo en que han sido observadas las arquitecturas en el noroeste argentino. …”
Get full text

Classification of Speech Emotion State Based on Feature Map Fusion of TCN and Pretrained CNN Model From Korean Speech Emotion Data by A-Hyeon Jo, Keun-Chang Kwak

“…In the third stage, we perform feature-map fusion using canonical correlation analysis (CCA), stationary wavelet transform (SWT), and fuzzy c-means-based principal component averaging (FCMPCA), respectively. …”
Get full text

Graded transcendental functions: an application to four-point amplitudes with one off-shell leg by Thomas Gehrmann, Johannes Henn, Petr Jakubčík, Jungwon Lim, Cesare Carlo Mella, Nikolaos Syrrakos, Lorenzo Tancredi, William J. Torres Bobadilla

“…We describe the derivation of canonical differential equation systems and present a method for fixing boundary conditions without the need for a full functional representation. …”
Get full text

Epoetin-alfa-induced osteogenesis in the bone organoid model by Natalia A. Nadezhdina, Oleg S. Gudyrev, Sergey V. Nadezhdin, Lyudmila M. Danilenko, Aleksandr A. Dolzhikov, Kristina K. Kremleva, Tatyana G. Pokrovskaya

“…Introduction: Erythropoietin interacts ETwith EPOR/βcR(CD131) and activates the non-canonical pathway JAK/STAT and PI3K/AKT. Phosphorylated STAT subunits were found to get dimerized and translocated into the nucleus to activate the expression of the Runx-2 and TGF-β genes. …”
Get full text

Machine Learning Model for Gas–Liquid Interface Reconstruction in CFD Numerical Simulations by Tamon Nakano, Michele Alessandro Bucci, Jean-Marc Gratien, Thibault Faney

“…Our approach is validated using analytical solutions and comparisons with conventional methods in the OpenFOAM framework on a canonical test. We present promising results for the efficiency of GNN-based approaches for interface reconstruction in multiphase flow simulations in the industrial context.…”
Get full text

Sustaining Biodiversity and Ecological Roles in a Heritage Landscape: The Role of Coffee Agroforestry in Kluncing, Indonesia by Agung Sih Kurnianto, Nilasari Dewi, Hari Sulistyowati, Arif Mohammad Siddiq, Tri Ratnasari, Husnul Khowatini, Roni Yulianto, Anggun Sausan Firdaus

“…Trophic network modeling using NetworkX identified keystone species like Collocalia linchi (21.9% relative abundance) among birds and the Formicidae family (29.8% relative abundance) among coffee insects, emphasizing their critical roles in ecosystem balance. Canonical Correspondence Analysis (CCA) highlighted the influence of environmental factors on species distribution. …”
Get full text

Can Effects of a Generalized Uncertainty Principle Appear in Compact Stars? by João Gabriel Galli Gimenez, Dimiter Hadjimichef, Peter Otto Hess, Marcelo Netz-Marzola, César A. Zen Vasconcellos

“…On basis of a deformed Poisson canonical algebra with a parametrized minimum length scale that induces deviations from conventional Quantum Mechanics, fundamental questions involving the consistence, evidences and proofs of this approach as a possible cure for unbounded energy divergence are outlined. …”
Get full text