Virtual screening and directional preparation of xanthine oxidase inhibitory peptides derived from hemp seed protein by Xiaoni Huang, Jiajun Liao, Ping Shi, Xiaodong Pei, Chenghua Wang

“…The traditional nutritional and medical hemp (Cannabis sativa L.) seed protein were explored for the discovery and directional preparation of new xanthine oxidase inhibitory (XOI) peptides by structure-based virtual screening, compound synthesis, in vitro bioassay and proteolysis. …”
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Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood by Klara Mareckova, Ana Paula Mendes-Silva, Martin Jáni, Anna Pacinkova, Pavel Piler, Vanessa F. Gonçalves, Yuliya S. Nikolova

“…These medium to large effects were independent of sex, current BMI, cigarette smoking, cannabis, and alcohol use. These findings suggest that elevated FI score of mtDNA variants might contribute to premature aging in young adulthood.…”
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Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation by Chandrabhan Seniya, Ghulam Jilani Khan, Kuldeep Uchadia

“…Therefore, in this paper, an attempt was made to elucidate cholinesterase inhibition potential of secondary metabolite from Cannabis plant which has negligible or no side effect. …”
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La Reincidencia Delictiva en los Adolescentes que Cometen Delitos Graves y Tienen un Consumo de Drogas Elevado by Álvaro Fernández-Moreno, Natalia Redondo, José L. Graña

“…Se encontraron 12 variables predictoras: duración y régimen de medida, internamientos previos, número de delitos, nacionalidad, estudios previos, consumo de cannabis tras internamiento y problemas tras el internamiento en consumo de drogas, escolares, de empleo/recursos, psíquicos y legales. …”
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Phytocanabinoids and synthetic cannabinoids: from recreational consumption to potential therapeutic use – a review by Helena M. Teixeira, Helena M. Teixeira

“…The word “cannabinoid” refers to any chemical substance, regardless of structure or origin, that binds to the body’s cannabinoid receptors and that has effects similar to those produced by the Cannabis plant. Regarding their origin, cannabinoids can be classified into endocannabinoids, phytocannabinoids and synthetic cannabinoids. …”
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History of Illicit Stimulant Use Is Not Associated with Long-Lasting Changes in Learning of Fine Motor Skills in Humans by Gabrielle Todd, Verity Pearson-Dennett, Stanley C. Flavel, Miranda Haberfield, Hannah Edwards, Jason M. White

“…The study involved three groups: abstinent stimulant users (n=21; 27 ± 6 yrs) and two gender-matched control groups comprising nondrug users (n=16; 22 ± 4 yrs) and cannabis users (n=16; 23 ± 5 yrs). Motor learning was assessed with a three-minute visuomotor tracking task. …”
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Optimization of extraction and enrichment process of cannabidiol from industrial hemp and evaluation of its bioactivity by Junkai Wu, Xiaomeng Zhang, Xiaoqing Liu, Zunlai Sheng, Zunlai Sheng, Jianping Hu, Feiyan Zhang

“…IntroductionThe Cannabis Sativa L., a perennial dioecious herb renowned for its industrial applications, serves as the source of hemp. …”
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An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp by Tennille K. Marx, Robin Reddeman, Amy E. Clewell, John R. Endres, Erzsébet Béres, Adél Vértesi, Róbert Glávits, Gábor Hirka, Ilona Pasics Szakonyiné

“…A battery of toxicological studies was conducted on a supercritical CO2 extract of the aerial parts of the Cannabis sativa plant, containing approximately 25% cannabinoids. …”
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Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection by Michaela Dvorakova, Ken Mackie, Alex Straiker

“…Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. …”
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A Self-Emulsifying Nanococktail of Pomegranate and Cannabidiol Reduces Cognitive Decline in Mice by Shoseyov O, Palatnik A, Dadon-Freiberg M, Dagan O, Shaltiel Karyo R

“…Several studies have established the neuroprotective capacities of a pomegranate oil nano-formulation (Nano-PSO). In parallel, cannabis-derived cannabidiol (CBD) prevented social recognition deficits and reduced neuroinflammation in mice. …”
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Prevalence and patterns of substance use in West Africa: A systematic review and meta-analysis. by Godwin Omokhagbo Emmanuel, Folahanmi Tomiwa Akinsolu, Olunike Rebecca Abodunrin, Oliver Chukwujekwu Ezechi

“…<h4>Results</h4>The meta-analysis revealed the pooled prevalence rates of alcohol [44%], cannabis [6%], tramadol [30%], codeine [11%], and kolanut [39%]. …”
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Hypolipidemic Effect of Hemp Seed Oil from the Northern Morocco Endemic Beldiya Ecotype in a Mice Model: Comparison with Fenofibrate Hypolipidemic Drugs by Imane Mokhtari, Yassine Taaifi, Mohamed Harnafi, Kamal Belhaj, Farid Mansouri, Reda Melhaoui, Mohamed Addi, Christophe Hano, Souliman Amrani, Hicham Harnafi, Ahmed El Amrani

“…Introduction. Cannabis sativa is a source of oil seeds for pharmaceutical, cosmetic, and food uses. …”
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Physicians’ and patients’ perceived risks of chronic pain medication and co-medications in Quebec, Canada: a cross-sectional study by Gwenaëlle De Clifford-Faugère, Anaïs Lacasse, Hermine Lore Nguena Nguefack, Marimée Godbout-Parent, Aline Boulanger, Nancy Julien

“…For eight subclasses, the difference in the mean perceived risk score was > 2 points and statistically significant (p < 0.05): non-specific oral NSAIDs, acetaminophen in combination with an opioid, short-acting opioids, long-acting opioids, tricyclic antidepressants, antipsychotics, benzodiazepines, and medical cannabis. Conclusions Divergent risk perceptions between physicians and patients underscore the necessity of facilitating a more extensive discussion on medications and co-medications risks to empower patients to make informed decisions and participate in shared decision-making regarding their treatments.…”
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Associations between HEXACO personality traits, substance use disorders, and behavioral addictions: a protocol for a comprehensive systematic review and meta-analysis by Farangis Sharifibastan, Eilin Kristine Erevik, Katharina Teresa Enehaug Morken, Ståle Pallesen

“…This systematic review and meta-analysis aim to fill this gap by investigating the association between HEXACO personality traits and various addictions, including illegal substances (e.g., narcotics and cannabis) and behavioral addictions (e.g., gambling, gaming, social media addiction, and compulsive sexual behavior disorder) across different populations. …”
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Explorando o Potencial Terapêutico do Canabidiol em Crianças com Paralisia Cerebral: Uma Revisão Integrativa by Camila Harmuch, Anny Caroline Ribeiro Devechi, Cecily Barbosa, Ana Luisa Serrano Lima, Jéssica dos Santos Pini, André Estevam Jaques, Marcelle Paiano

“… Introdução Os primeiros ensaios clínicos com canabidiol em humanos foram descritos nos anos setenta, mas foi na década de 1990 que a descoberta de um sistema endógeno de sinalização de canabinoides despertou o interesse no potencial terapêutico da cannabis no tratamento de distúrbios do sistema nervoso, incluindo a epilepsia. …”
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What are the characteristics of disposable electronic cigarettes users in Switzerland? A quantitative study among 14–25 year olds by Luc Lebon, Karin Zürcher, Lorraine Chok, Diana Fernandes-Palhares, Jérémy Cros, Alexandre Dubuis, Cathy Berthouzoz, Yara Barrense-Dias

“…At the multivariate level, compared with the NEVER group, participants in the CURRENT group were more likely to have used cigarettes and cannabis in the last 30 days, to report family electronic cigarettes use and to have seen online advertising for DEC. …”
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Primary Spontaneous Pneumothorax Admitted in Emergency Unit: Does First Episode Differ from Recurrence? A Cross-Sectional Study by S. Kepka, J. C. Dalphin, A. L. Parmentier, J. B. Pretalli, M. Gantelet, N. Bernard, F. Mauny, T. Desmettre

“…Clinical presentation, age, gender, smoking habits, and use of cannabis were similar in both groups. No clinical factor associated with recurrence was identified by multivariate analysis. …”
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Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics by David Chamoso-Sanchez, Martina Panini, Clarissa Caroli, Matilde Marani, Lorenzo Corsi, Francisco J Rupérez, Antonia Garcia, Federica Pellati

“…CBD is a non-psychoactive compound present in Cannabis sativa L., which has shown an antiproliferative action in these type of cancer cells. …”
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Survival outcomes of marijuana users in p16 positive oropharynx cancer patients by Han Zhang, Michael Xie, Marc Levin, Stuart D. Archibald, B. Stanley Jackson, J. E. M. Young, Michael K. Gupta

“…This finding has implications for both de-escalation regimes and the use of cannabis as a therapeutic agent.…”
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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature by Sandra Maria Barbalho, Beatriz Leme Boaro, Jéssica da Silva Camarinha Oliveira, Jiří Patočka, Caroline Barbalho Lamas, Masaru Tanaka, Lucas Fornari Laurindo

“…The key findings highlight that plants like <i>Cleistocalyx nervosum</i> var. paniala, <i>Curcuma longa</i>, <i>Cannabis sativa</i>, and <i>Dioscorea nipponica</i> reduce pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), inhibit enzymes (COX-2 and iNOS), and activate antioxidant pathways, particularly Nrf2. …”
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