Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer by Muhammet Calik, Ilknur Calik, Gokhan Artas, Ibrahim Hanifi Ozercan

“…TRPM7 is known to play a key role in tumor progression by regulating cellular proliferation, migration, and invasion in various cancer cell lines. However, there are no comprehensive clinical studies about the effect of TRPM7 expression on gastric cancer (GC) prognosis. …”
Get full text

Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin by Jichao Sun, Dinglan Wu, Liuhai Zheng, Huifang Wang, Jihao Zhou, Guangwei Shi, Jingbo Ma, Yuke Jiang, Zhiyu Dong, Jiexuan Li, Yuan-Qiao He, Chengchao Xu, Zhijie Li, Jigang Wang

“…Our results show that G6-CAR-NK92 cells can effectively kill various tumor cell lines in vitro on which ERp57 is induced or intrinsically expressed, and also exhibit potent antitumor effects in cancer cell-derived xenograft and patient-derived xenograft mouse models. …”
Get full text

Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant by Yan Zhou, Ting Zhang, Zhirong Wang, Xuemei Xu

“…The two early viral oncoproteins, E6 and E7, are continuously expressed in most HPV-related pre- and cancerous cells, and are ideal targets for therapeutic vaccines. …”
Get full text

Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis by Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, Qiong Mao, Xingzhe Wang, Lizhen Jiang, De-Chen Lin, Yueyuan Zheng

“…We observe that in cancer cell lines, including those from esophageal and breast cancer, long LOCKs shift from short-PMDs to intermediate-PMDs and long-PMDs. …”
Get full text

Transcriptome Analysis of the Effect of Acute Ammonia Stress on <i>Pseudobagrus ussuriensis</i> Liver Tissue by Shun Shi, Xiaohui Sun, Chunnuan Zhang, Chenran Lv, Yajuan Liu, Juan Du, Qian Qi

“…In-depth analysis revealed the stress caused multiple substitutions of SNP sites in pik3ca and kras, blocking the PI3K/Akt signaling pathway to prevent cancer cell proliferation and spread, accelerating the apoptosis of damaged cells. …”
Get full text

Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach by Vibhuti Saxena, Pruthanka Patil, Purva Khodke, Bajarang Vasant Kumbhar

“…Inhibiting katanin’s function could potentially hinder the uncontrolled growth of cancerous cells, making it an attractive target for novel anti-cancer therapies. …”
Get full text

Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer by Seungyeul Yoo, Ayushi S. Patel, Sarah Karam, Yi Zhong, Li Wang, Feng Jiang, Ranran Kong, Sharon Bikvan, Wenhui Wang, Abhilasha Sinha, Charles A. Powell, Jun Zhu, Hideo Watanabe

“…GRN and its associated genes were linked to cancer cell intrinsic immunogenicity, and single-cell RNA-seq data revealed that GRN expression is particularly high in subsets of tumor-associated macrophages. …”
Get full text

Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line by Mohammed Nihal Hasan, Syed Shoeb Razvi, Hani Choudhry, Mohammed A. Hassan, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Khalid Omer Abualnaja, Majed A. Halwani, Abdulrahman Labeed Al-Malki, Jiannis Ragoussis, Wei Wu, Christian Bronner, Tadao Asami, Mahmoud Alhosin

“…Strigolactone (SL) is a novel class of phytohormone, whose analogues have been reported to possess anticancer properties on a panel of human cancer cell lines through inducing cell cycle arrest, destabilizing microtubular integrity, reducing damaged in the DNA repair machinery, and inducing apoptosis. …”
Get full text

Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…The specific design and structural features of ISB 1442 enable: 1) enhanced trans binding to adjacent CD38 molecules to increase Fc density at the cancer cell surface; 2) prevention of avid cis binding to monomeric CD38 to minimize blockade by soluble shed CD38; and 3) greater binding avidity, with a slower off-rate at high CD38 density, for increased specificity. …”
Get full text

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. …”
Get full text

Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota by Yunjiao Shen, Yunjiao Shen, Yansong Gao, Ge Yang, Zijian Zhao, Yujuan Zhao, Lei Gao, Shengyu Li

“…Total minor ginsenosides (TMG) were obtained through the fermentation of major ginsenosides with Lactiplantibacillus plantarum, and potential anticancer effects of TMGs on the mouse colon cancer cell line CT26.WT, in vitro and in vivo, were investigated.Materials and MethodsWe employed the Cell Counting Kit-8 (CCK-8), TdT-mediated dUTP nick end labeling (TUNEL), and Western blot analysis in vitro to explore the anti-proliferative and pro-apoptotic functions of TMG in CT26.WT cells. …”
Get full text

Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives by Assem Barakat, Hazem A. Ghabbour, Abdullah Mohammed Al-Majid, Qurat-ul-ain, Rehan Imad, Kulsoom Javaid, Nimra Naveed Shaikh, Sammer Yousuf, M. Iqbal Choudhary, Abdul Wadood

“…All barbiturates derivatives (4a–4x, 4z, and 5a–5m) were found to be noncytotoxic against human prostate (PC-3), Henrietta Lacks cervical (HeLa) and Michigan Cancer Foundation-7 breast (MCF-7) cancer cell lines, and 3T3 normal fibroblast cell line, except 4y which was cytotoxic against all the cell lines.…”
Get full text

Influence of Mesalazine on Ferroptosis-Related Gene Expression in In Vitro Colorectal Cancer Culture by Joanna Słoka, Barbara Strzałka-Mrozik, Sebastian Kubica, Ilona Nowak, Celina Kruszniewska-Rajs

“…<b>Methods:</b> The study was conducted on the colon cancer cell line DLD-1 and normal intestinal epithelial cells from the CCD 841 CoN cell line. …”
Get full text

Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice by Peng Yu, Weiyin Xu, Yanqi Li, Zhaoyang Xie, Simeng Shao, Jianing Liu, Ying Wang, Long Wang, Hongmei Yang

“…As expected, Rg3/Rg5-BG demonstrated a dose-dependent reduction in cancer cell viability, along with the induction of cell apoptosis and cell cycle arrest. …”
Get full text

Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…The compounds have demonstrated efficacy in vitro and in vivo, affecting various cancer cell lines with minimal toxicity to normal cells. …”
Get full text

Bilosomal Co-Encapsulated Tamoxifen and Propranolol for Potentiated Anti-Breast Cancer Efficacy: In Vitro and In Vivo Investigation by Toka T. Elebyary, Amal A. Sultan, Sally E. Abu-Risha, Gamal M. El Maghraby, Manna Amin

“…Histopathological investigations reflected a significant decline in tumor giant cells and mitotic figures, implying the in vivo capability of the TAM/PRO combination to interfere with cancer cell proliferation and persistence. <b>Conclusions</b>: The overall results demonstrated the impact of repurposed PRO to enhance the anti-breast cancer activity of TAM when both were co-encapsulated into bilosomes.…”
Get full text

The Endocannabinoid, Anandamide, Acts as a Novel Inhibitor of LPS-Induced Inflammasome Activation in Human Gastric Cancer AGS Cell Line: Involvement of CB1 and TRPV1 Receptors by Sahar Sadat Sedeighzadeh, Hamid Galehdari, Mohammad Reza Tabandeh, Mehdi Shamsara, Ali Roohbakhsh

“…In conclusion, our results would indicate a novel anticancer effect of anandamide by attenuation of inflammasome activation and consequently reducing IL-1β production in human AGS cancer cell line via CB1R and TRPV1R.…”
Get full text

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms by David Trombley McSwiggen, Helen Liu, Ruensern Tan, Sebastia Agramunt Puig, Lakshmi B Akella, Russell Berman, Mason Bretan, Hanzhe Chen, Xavier Darzacq, Kelsey Ford, Ruth Godbey, Eric Gonzalez, Adi Hanuka, Alec Heckert, Jaclyn J Ho, Stephanie L Johnson, Reed Kelso, Aaron Klammer, Ruchira Krishnamurthy, Jifu Li, Kevin Lin, Brian Margolin, Patrick McNamara, Laurence Meyer, Sarah E Pierce, Akshay Sule, Connor Stashko, Yangzhong Tang, Daniel J Anderson, Hilary P Beck

“…The sensitivity of htSMT revealed a new correlation between ER dynamics and the ability of ER antagonists to suppress cancer cell growth. Therefore, measuring protein motion at scale is a powerful method to investigate dynamic interactions among proteins and may facilitate the identification and characterization of novel therapeutics.…”
Get full text

Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety... by Mohamed Imath, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Ramalingam Karthik Raja, Gholamreza abdi

“…The aim of present study was examined antibacterial, antioxidant, antibiofilm and cytotoxicity of liver cancerous cells using Fioria vitifolia mediated chitosan nanoparticles (FV-CNPs). …”
Get full text

A graph neural network approach for hierarchical mapping of breast cancer protein communities by Xiao Zhang, Qian Liu

“…Further overlaps with breast cancer cell dependencies revealed SUPT6H and RAD21, along with their respective protein systems, HOST:37 and HOST:861, as potential biomarkers. …”
Get full text