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Evaluation of Tinospora cordifolia stem extract bioactive content and anticancer activity against breast cancer cells
Published 2025-01-01“…This study aims to explore the bioactive potential of Tinospora cordifolia stem extract by investigating the content of flavonoids, phenols, terpenoids and alkaloids as well as the cytotoxic and apoptotic effects on T47D breast cancer cells. Analysis of bioactive compound content revealed a total flavonoid content of 29.7 ± 0.30 mg QE/g extract, a total phenol content of 120.4 ± 4.25 mg GAE/g extract, a total terpenoid content of 2.41 ± 2.18 mg LE/g extract and a total alkaloid content of 2.55 ± 0.27 mg LE/g extract. …”
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Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells
Published 2025-01-01“…We recently described that lung cancer cells that express more germ cell cancer genes (GC genes, genes that are usually restricted to the germ line) can repair DNA double-strand breaks more rapidly, show higher rates of proliferation and are more resistant to ionizing radiation than cells that express fewer GC genes. …”
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163
Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters
Published 2022-03-01“…Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is overexpressed in many cancer cells. Objective: The gold nanoclusters conjugated with a single domain antibody targeting CEACAM6 of 2A3 (2A3-AuNCs) were synthesized for the inhibition of cancer cells. …”
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Antiproliferative Effect of Grammatophyllum speciosum Ethanolic Extract and Its Bioactive Compound on Human Breast Cancer Cells
Published 2021-01-01“…The antiproliferation effects of the G. speciosum pseudobulb ethanolic extract (GSE) and isovitexin (bioactive constituent) were investigated on the MCF-7 human breast cancer cell line using MTT and colony formation assay. …”
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Protein Kinase Cα Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells
Published 2013-01-01“…Conversely, knockdown of PKCα reduced ER-dependent gene expression and inhibited estrogen-induced proliferation of endometrial cancer cells. The ability of PKCα to potentiate estrogen activation of ER-dependent transcription was attenuated by inhibitors of phosphoinositide 3-kinase (PI3K) and Akt. …”
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Expression of p120-Catenin Isoforms Correlates with Genomic and Transcriptional Phenotype of Breast Cancer Cell Lines
Published 2007-01-01“…We investigated the expression of p120-catenin isoforms in a collection of breast cancer cell lines with distinct molecular profiles and expressing different cadherins. …”
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Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro
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170
Silk of the Indian meal moth Plodia interpunctella (Hübner, 1813) affects the human colon cancer cells
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Dose and time dependent cytotoxicity of Blepharis maderaspatensis (L) against various human cancer cell lines
Published 2025-01-01“…Results: Ethanolic extract of B. maderaspatensis was effective cytotoxic agent against all the tested cancer cell lines in dose and time-dependent manner. …”
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Retracted: Effect and Mechanism of lncRNA CERS6-AS1 on the Biological Behavior of Prostate Cancer Cell
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The Mechanism of Scopolamine’s Effect on Migration Function of Lung Cancer Cells: A Network Pharmacology and Bioinformatics Perspective
Published 2024-01-01“…Scopolamine has a significant effect on various cellular functions in lung cancer cells, potentially reducing the likelihood of metastasis. …”
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Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients
Published 2025-01-01“…Here, we have compiled eight scRNA-seq datasets from nine cancer types, encompassing 223 patients, 90,270 cancer cells, and 265,671 other cell types. This compilation forms a unique resource tailored to investigate how cancer cells respond to ICB treatment across cancer types. …”
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MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells
Published 2023-01-01“…Collectively, MLLT11 siRNA elicited ameliorative properties on breast cancer cells, possibly via the inhibition of the PI3K/AKT signaling pathway.…”
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CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells
Published 2025-01-01“…Data mining of whole-genome genetic dependency screens suggest Cell Division Cycle 40 (CDC40) to be an essential protein for lung cancer cell survival. We characterized CDC40 knockdown effects in multiple lung cancer cell lines, revealing induced cell cycle defects that resulted in strong growth inhibition and activation of apoptosis. …”
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GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells
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