Design, Synthesis and Potential Anti-Proliferative Activity of Some Novel 4-Aminoquinoline Derivatives by Ghorab Mostafa M., Al-Said Mansour S., Arafa Reem K.

“…All the newly synthesized comounds were tested for in vitro antiproliferative activity against the MCF-7 breast cancer cell line. Seventeen of the novel compounds showed higher activity than the reference drug doxorubicin. …”
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Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors by Alshimaa A. Y. Ahmed, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif

“…IntroductionThis work outlines the design, synthesis, and biological evaluation of a new series of benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit the EGFR pathway.MethodsThe research assesses the antiproliferative efficacy of compounds 6a-i and 10a-i against various cancer cell lines.Results and DiscussionThe research emphasizing hybrids 6i and 10e for their remarkable activity, with GI50 values of 29 nM and 25 nM, respectively. …”
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Label-Free Surface-Enhanced Raman Scattering for Genomic DNA Cytosine Methylation Reading by Kazi Morshed Alom, Anastasiia Tukova, Nana Lyu, Alison Rodger, Yuling Wang

“…The method was applied to determine the hypermethylated levels of the germline of colorectal cancer cell lines SW48 and SW480. Our simple label-free method holds the potential to read the disease-associated methylation of genomic DNA.…”
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Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity by Mariateresa Badolato, Gabriele Carullo, Francesca Aiello, Antonio Garofalo

“…Most of synthesized compounds showed a good inhibitory potency against PDI and particularly 4-methyl substituted 2,6-di-tert-butylphenol derivatives (8–10) presented an antiproliferative activity in a wide panel of human cancer cell lines, including ovarian ones.…”
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Expanding the miRNA Transcriptome of Human Kidney and Renal Cell Carcinoma by Adam P. Sage, Brenda C. Minatel, Erin A. Marshall, Victor D. Martinez, Greg L. Stewart, Katey S. S. Enfield, Wan L. Lam

“…We find that these novel kidney miRNAs are also expressed in renal cancer cell lines. Moreover, these sequences are differentially expressed between ccRCC and matched nonmalignant tissues, implicating their involvement in ccRCC biology and potential utility as tumour-specific markers of disease. …”
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Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects by Selim Öğüt, Melikenur Türkol, Seydi Yıkmış, Esra Bozgeyik, Gholamreza Abdi, Emine Kocyigit, Rana Muhammad Aadil, Nilay Seyidoglu, Deniz Karakçı, Nazlı Tokatlı

“…In experiments on A549 (lung), MCF-7 (breast) and HT-29 (colon) cancer cell lines, ultrasound-treated vinegar increased apoptotic effects, suppressed cell migration and reduced necrosis rates in some cell lines. …”
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Biological properties of Moringa oleifera: A systematic review of the last decade [version 1; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Besides, cytotoxic effects, apoptotic and antiploriferative activity against several cancer cell lines has been demonstrated. On the other hand, the antimicrobial potential of M. oleifera was also evidenced, especially against multidrug-resistant strains. …”
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Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology by Kenneth Maiese, Jinling Hou, Zhao Zhong Chong, Yan Chen Shang

“…In particular, both the growth factor and cytokine erythropoietin (EPO), and members of the mammalian forkhead transcription factors of the O class (FoxOs), may offer the greatest promise for new treatment regimens, since these agents and the cellular pathways they oversee cover a range of critical functions that directly influence progenitor cell development, cell survival and degeneration, metabolism, immune function, and cancer cell invasion. Furthermore, both EPO and FoxOs function not only as therapeutic targets, but also as biomarkers of disease onset and progression, since their cellular pathways are closely linked and overlap with several unique signal transduction pathways. …”
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Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells by Fariborz Bahrami, Filip Kukulski, Joanna Lecka, Alain Tremblay, Julie Pelletier, Liliana Rockenbach, Jean Sévigny

“…Here we investigated whether IL-8 release by intestinal epithelial HT-29 cells, a cancer cell line, is modulated by extracellular nucleotide metabolism. …”
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Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer by Ziqiang Chen, Ting Yu, Yunhe Wang, Jiaxin Li, Bo Zhang, Liya Zhou

“…Specifically, we detail how TCM inhibits aerobic glycolysis by downregulating key glycolytic enzymes and metabolic pathways, thereby reducing the energy supply essential for cancer cell proliferation. We examine how TCM suppresses angiogenesis by targeting the vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) pathways, effectively starving tumors of nutrients and oxygen required for growth and metastasis. …”
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Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts by Ersilia Alexa, Corina Danciu, Isidora Radulov, Diana Obistioiu, Renata Maria Sumalan, Adriana Morar, Cristina Adriana Dehelean

“…Also, the in vitro antimicrobial effect against Staphylococcus aureus and the antiproliferative activity against two cancerous cell lines (A375 and MDA-MB-231) using the MTT assay were tested. …”
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Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells by Anine Crous, Elvin Chizenga, Natasha Hodgkinson, Heidi Abrahamse

“…Photodynamic therapy (PDT) is a clinically approved, minimally invasive, therapeutic procedure that can exert a selective cytotoxic activity toward cancerous cells while reducing toxicity to normal cells. …”
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Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling P... by Tsung-Chang Tsai, Wen-Tung Wu, Jen-Jie Lin, Jui-Hsin Su, Yu-Jen Wu

“…This study was performed to examine the mechanisms of the migration and invasion characteristics of HCC, with the aim of reducing metastasis by inhibiting cancer cell migration and invasion. In this study, we used Stellettin B, an active compound isolated from Stelletta sponges, as the experimental drug and evaluated its inhibition effects on cell migration and invasion in human hepatoma cells (HA22T and HepG2). …”
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Osteosarcoma of the Mandible in an Elderly Patient by Isao Hoshi, Ryosuke Abe, Kei Onodera, Yu Ohashi, Tadashi Kawai, Ikuya Miyamoto, Toshimi Chiba, Yasunori Takeda, Hiroyuki Yamada

“…Osteosarcoma is a malignant tumor in which the cancerous cells produce an osteoid matrix or mineralized bone. …”
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Chemical composition, antimicrobial and anticancer activities of Paederia lanuginosa WALL by Hiep Hoang Phu, Tran Thi Hong, Van Khang Pham

“…The extract of P. lanuginosa leaves also showed moderate inhibitory activity against the three tested cancer cell lines MKN-7, SW480, and HT29, with IC50 values ranging from 25.26 to 28.83 µg/mL.…”
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Ion suppression correction and normalization for non-targeted metabolomics by Iqbal Mahmud, Bo Wei, Lucas Veillon, Lin Tan, Sara Martinez, Bao Tran, Alexander Raskind, Felice de Jong, Yiwei Liu, Jibin Ding, Yun Xiong, Wai-kin Chan, Rehan Akbani, John N. Weinstein, Chris Beecher, Philip L. Lorenzi

“…To demonstrate a routine application of the Workflow, we employ the Workflow to study ovarian cancer cell response to the enzyme-drug L-asparaginase (ASNase). …”
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A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy by Zhichao Wang, Yuqi Tang, Quan Li

“…This nanoplatform is found to have the characteristics of cancer cell targeting, pH response, near-infrared fluorescence imaging, and lysosome targeting. …”
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Evaluation of anticancer potency of Cu-isatin-1-(2-pyridyl) piperazine thiosemicarbazone (Cu-Istpypz) against epidermoid carcinoma cell line (A431) by Indranil Banerjee, Piyush Kumar, Narendra K. Singh, Paras N. Yadav, Yuba Raj Pokharel

“…Among the compounds synthesized, copper conjugated isatin-thiosemicarbazone derivative, Cu-Istpypz, showed considerable anti-proliferative activity against A431 (Skin Cancer) and A549 (Lung Cancer) cell lines. Cell viability assay using crystal violet dye exhibited the effects of the compounds against those cell lines. …”
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A Bayesian active learning platform for scalable combination drug screens by Christopher Tosh, Mauricio Tec, Jessica B. White, Jeffrey F. Quinn, Glorymar Ibanez Sanchez, Paul Calder, Andrew L. Kung, Filemon S. Dela Cruz, Wesley Tansey

“…In a prospective combination screen of a library of 206 drugs on a collection of pediatric cancer cell lines, the BATCHIE model accurately predicts unseen combinations and detects synergies after exploring only 4% of the 1.4M possible experiments. …”
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Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis by Claire M. Payne, Cheray Crowley-Skillicorn, Hana Holubec, Katerina Dvorak, Carol Bernstein, Mary Pat Moyer, Harinder Garewal, Harris Bernstein

“…Rapamycin pre-treatment of the apoptosis-resistant colon cancer cell line, HCT-116RC (developed in our laboratory), resulted in a significant decrease in DOC-induced cell death. …”
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