Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage by Diego Alem, César X. García-Laviña, Francisco Garagorry, Dardo Centurión, Joaquina Farias, Hany Pazos-Espinosa, María Noel Cuitiño-Mendiberry, Carolina Villadóniga, Susana Castro-Sowinski, Martín Fló, Federico Carrión, Brenda Iglesias, Kevin Madauss, Lucía Canclini

“…Subsequently, the amyloid proteome of the RT4 non-invasive and HT1197 invasive bladder cancer cell lines was identified and included oncogenes, tumor suppressors, and highly expressed cancer-related proteins. …”
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XMRV Discovery and Prostate Cancer-Related Research by David E. Kang, Michael C. Lee, Jaydip Das Gupta, Eric A. Klein, Robert H. Silverman

“…XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines. XMRV also traffics to prostate in a nonhuman primate model of infection. …”
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Integrating single-cell RNA-seq and bulk RNA-seq to explore prognostic value and immune landscapes of methionine metabolism-related signature in breast cancer by Yanxian Gao, Ziyu Feng, Hailong Zhao, Xinghai Liu, Muyu Zhu, Xiafei Yu, Xiaoan Liu, Xian Wu, Jing Tao

“…Subsequent in vitro experiments demonstrated that silencing APOC1 reduced the generation of tumor-associated macrophages (TAMs) with an M2 phenotype while significantly decreasing the proliferation, invasion, and migration of MDA-MB-231 and MDA-MB-468 breast cancer cell lines.ConclusionWe established a prognostic risk score consisting of genes associated with methionine metabolism, which helps predict prognosis and response to treatment in BC. …”
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Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects by Harshita Sachdeva, Rekha Saroj, Sarita Khaturia, Diksha Dwivedi, Om Prakash Chauhan

“…Compounds have also been evaluated for cytotoxic effects against human colon cancer cell line Colo205.…”
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Chemical tools to define and manipulate interferon-inducible Ubl protease USP18 by Griffin J. Davis, Anthony O. Omole, Yejin Jung, Wioletta Rut, Ronald Holewinski, Kiall F. Suazo, Hong-Rae Kim, Mo Yang, Thorkell Andresson, Marcin Drag, Euna Yoo

“…We further demonstrate that USP18 ABPs can be utilized to profile differential activities of USP18 in lung cancer cell lines, providing a strategy that will help define the activity-related landscape of USP18 in different disease states and unravel important (de)ISGylation-dependent biological processes.…”
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Modeling synergy and individual effects of X-ray induced photodynamic therapy components by Farideh. S. Hossein, Nadia Naghavi, Ameneh Sazgarnia, Atefeh Vejdani Noghreiyan

“…Simulation results predicted necrosis and apoptosis death of cancerous cells and estimated the minimum XPDT efficiency under specific conditions. …”
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Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade by Yasir Osman Ali Abdalla, Bavani Subramaniam, Shaik Nyamathulla, Noorasyikin Shamsuddin, Norhafiza M. Arshad, Kein Seong Mun, Khalijah Awang, Noor Hasima Nagoor

“…Besides, critical analysis of their molecular targets and underlying mechanisms on multiple cancer cell lines, an in-depth probe of their toxicological screening on rodent models is outlined as well to observe the prevalence of their toxicity towards host. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. …”
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Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools by Nur Alia Natasya Zabidi, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Tieng Yew Fu, Imilia Ismail, Muhammad Redha Abdullah Zawawi, Jodi Woan-Fei Law, Learn-Han Lee, Nurul-Syakima Ab Mutalib

“…SLC genes encode transporters that play vital roles in maintaining cellular homeostasis, and alterations in their DNA methylation can influence nutrient and metabolite transport, impacting cancer cell behavior. This proposal aims to investigate the DNA methylation status of SLC genes in CRC, utilizing microarray technology and a suite of bioinformatics tools. …”
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Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives by Ka Zhang, Yi-Wen Zhu, Ao-Qi Tang, Ze-Tao Zhou, Yi-Lun Yang, Zi-Hui Liu, Yan Li, Xiao-Yi Liang, Zhi-Fen Feng, Jun Wang, Tong Jiang, Qi-Ying Jiang, Dong-Dong Wu

“…Alternation of H2S level has been widely demonstrated to induce an array of disturbances in important cancer cell signaling pathways. As a result, the effects of H2S-catalyzing enzymes in cancers also attract widspread attention. 3-mercaptopyruvate sulfurtransferase (3-MST) is privileged to be one of them. …”
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Wnt5a Signaling in Normal and Cancer Stem Cells by Yan Zhou, Thomas J. Kipps, Suping Zhang

“…Recent studies show the involvement of Wnt5a signaling in regulating normal and cancer stem cell self-renewal, cancer cell proliferation, migration, and invasion. …”
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Exploring Amanita muscaria (L.) Lam.: Cytotoxic, proapoptotic and antiferroptotic effect of acetone extract on JAR choriocarcinoma cell line by Milojević Sara D., Nikodijević Danijela D., Milutinović Milena G., Kosanić Marijana M., Petrović Nevena N., Jovanović-Krivokuća Milica G., Nacka-Aleksić Mirjana M.

“…The pharmaceutical industry has long focused on nature-derived biologically active compounds to address challenges in cancer treatment, particularly overcoming cancer cell resistance to programmed cell death, including apoptosis and ferroptosis. …”
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Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile by Mohareb Rafat M., Abdallah Amira E. M., Ahmed Ebtsam A.

“…Cytotoxicity effects of the newly synthesized products against six cancer cell lines, namely, human gastric cancer (NUGC), human colon cancer (DLD- 1), human liver cancer (HA22T and HEPG-2), human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated. …”
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Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release by Jinjing Xing, Yeqiang Cai, Yikun Wang, Haifu Zheng, Yujia Liu

“…The cytotoxicity, targeting effect, and drug release of human cervical cancer cell line (HeLa) were studied by cell vitality and imaging experiments. …”
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Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives by Zou Xun-Zhong, Feng An-Sheng, Zeng Fu-Ran, Lai Min-Cheng, Liao Yan-Zhi, Mei Meng, Li Yu

“…The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.…”
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Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics by James Wang, Jai Woong Seo, Aris J. Kare, Martin Schneider, Mallesh Pandrala, Spencer K. Tumbale, Marina N. Raie, Gokce Engudar, Nisi Zhang, Yutong Guo, Xiaoxu Zhong, Sofia Ferreira, Bo Wu, Laura D. Attardi, Guillem Pratx, Andrei Iagaru, Ryan L. Brunsing, Gregory W. Charville, Walter G. Park, Katherine W. Ferrara

“…We find that selected cancer cell surface markers are spatially correlated and provide specific cancer localization, whereas the spatial correlation between cancer markers and immune-related or fibroblast markers is low. …”
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Therapeutic Effect of Cu(II) Complex with Photocatalytic Property on Gastric Cancer by Inhibiting the Proliferation of Tumor Cells by Dan Yu, Shuqin Li

“…However, we also used real-time reverse transcription-polymerase chain reaction (RT-PCR) to detect the activation of vascular endothelial growth factor (VEGF) signaling pathway, and Cell Counting Kit-8 (CCK-8) method was used to calculate the inhibition activity of 1 on gastric cancer cell viability.…”
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Olfm4 Is Highly Expressed in HCC Patients and as a Biomarker and Therapeutic Target for HCC by Yulong Wei, Qingzhu Song, Fenglan Zhang, Tian Yuan

“…It is confirmed that OLFM4 contributes to cancer cell proliferation, and HIF1α is involved in this process. …”
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Bioactive Volatile Content of the Stem and Root of Centaurea carduiformis DC. subsp. carduiformis var. carduiformis by Ibrahim Demirtas, Ayse Sahin

“…The hexane extract was significantly inhibited proliferation of Vero, HeLa, and C6 cancer cell lines with absorbance values. The extract of CCS and CCR showed the highest activity against the Vero, HeLa, and C6 cell lines at 500 μg/mL and 1000 μg/mL.…”
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PROTAC technology for prostate cancer treatment by Zhen Wang, Dingpeng Zhang, Hiroyuki Inuzuka, Wenyi Wei

“…The metastatic spread of PrCa is the primary cause of mortality, causing cancer cell dissemination to distant sites, such as bones, the pelvis, and various visceral organs. …”
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