Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies by Oghenejoboh Ufuoma Modupe, Sonibare Oluwadayo Olatunde, Muhammad Waseem, Ekundayo Olusegun, Sirajul Haq, Ahad Amer Alsaiari, Jamoliddin Razzokov

“…The nanoparticles had high drug loading capacity (<10 %), promising cytotoxic activity against MCF-7 breast cancer cell lines and α-glucosidase inhibitory activities ranging between 5.6 and 13.4 μM comparable to standard drug acarbose (9.8 μM), respectively. …”
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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The three most active compounds: 4e (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-nitrobenzamide), 4f (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-chlorobenzamide) and 4g (4-bromo-N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)benzamide), were evaluated for anticancer activity against human OS cancer cell line (MG-63), liver cancer cell line (HepG2), lung cancer cell line (A549) and cervical cancer (HeLa), using MTT assay. …”
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Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors by Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, Jieqing Liu, Junjie Ma

“…Importantly, 14 could upregulate the expression of PD-L1 and CXCL10 in a PD-L1 low-expression cancer cell line (MCF-7), highlighting the potential to enhance efficacy by recruiting T-cell infiltration into TME and improving the response of PD-1/PD-L1 inhibitor associated with PD-L1 low-expression. …”
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GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma by Toshihiko Inowa, Keiichi Hishikawa, Yumi Matsuzaki, Takayuki Isagawa, Takumi Takeuchi, Hiroyuki Aburatani, Tadaichi Kitamura, Toshiro Fujita

“…Side population (SP) cells are an enriched population of stem, and the existence of SP cells has been reported in human cancer cell lines. In this study, we performed an SP analysis using 11 human cancer cell lines and confirmed the presence of SP cells in an embryonic carcinoma cell line, NEC8. …”
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A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems by Thuc Ngoc Dinh, Mai Vu Thi Ha, Luong Ngo Xuan, Huan Trinh Thi, Huong Nguyen Thi, Mai Nguyen Thi Ngoc, Giap Tran Huu, Oanh Vu Thi Kim, Thanh Le Nguyen

“…Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 8–10 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively.…”
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In Vitro Model for Studying Malignancy Associated Changes by Xiao Rong Sun, Yonghong Zheng, Calum MacAulay, Stephen Lam, Alexei Doudkine, Branko Palcic

“…In this study we examined changes in nuclear features of normal human bronchial epithelial cells (NHBE) when they were co‐cultured with cells derived from a lung cancer cell line NCI‐H460. Using discriminant function analysis, nuclear features were determined which allow maximal discrimination between normal cells incubated with or without cancerous cells. …”
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Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties by Jan Šťastný, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Tomáš Skala, Andrea Bernardos, Andrea Bernardos, Andrea Bernardos, Petr Maršík, Araceli Lérida-Viso, Araceli Lérida-Viso, Araceli Lérida-Viso, Jaroslav Matějka, Anna Mascellani Bergo, María Dolores Marcos, María Dolores Marcos, María Dolores Marcos, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ivan Jablonský, Pavel Klouček

“…Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration of the most active components in different species or genotypes, new formulation techniques are in development. …”
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Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells by Vladimir F. Niculescu

“…This work aims to highlight the emerging field of evolutionary cancer cell biology (ECCB), which points to the deep homology between cancer and protist life cycles tracing back to the common ancestor of amoebozoans, metazoans, and fungi (AMF). …”
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Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer by Keyuan Xiao, Xiang Li, Ihsan Ullah, Wenqing Hu, Kaiqiang Wang, Fan Yang, Chengyu Yang, Chunqi Feng, Liang Zong, Xinghua Li

“…BackgroundThe Apoptosis-Stimulating Protein of P53 (ASPP) family contributes to apoptosis regulation and tumor suppression, with ASPP1 influencing processes like cancer cell proliferation, invasion, and migration. …”
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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…Crucially, PERs modulate cancer cell behaviors including proliferation, apoptosis, and migration by influencing the levels of cell cycle proteins and stimulating the expression of oncogenes c-Myc and MDM2. …”
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Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents by Çevik Ulviye Acar, Osmaniye Derya, Levent Serkan, Sağlik Begüm Nurpelin, Çavuşoğlu Betül Kaya, Karaduman Abdullah Burak, Özkay Yusuf, Kaplancikli Zafer Asim

“…Among the tested compounds, compound 4y (N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(p-tolylamino)-1,3,4-thiadiazol-2-yl)thio)acetamide), showed promising cytotoxic activity against MCF7 cancer cell with an IC50value of 0.084 ± 0.020 mmol L−1 and against A549 cancer cell with IC50 value of 0.034 ± 0.008 mmol L−1, compared with cisplatin. …”
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Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract by Faaiza Naaz K, Alavya Tiwari, Aabid Hussain Shaik, Indumathi P, Brianna Brianna, Ayaz Anwar, Mohammed Rehaan Chandan

“…At 125 μg/mL, the cells exhibited extreme cytotoxicity against cancer cell lines, with a viability of only 87.66%, showing a 12.3% decrease compared to the control.…”
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Evaluation of cytotoxic, antimicrobial, and antioxidant activi-ties of Echium italicum L. in MCF-7 and HepG2 cell lines by Dilek Arslan Atessahin, Semih Dalkilic, Lütfiye Kadioglu Dalkilic, Dudu Bayindir, Elif Cetinkaya

“…Its anticancer effect was tested in HepG2 (liver cancer) and MCF-7 (breast cancer) cell lines. Its antimicrobial effect was also investigated in Candida albicans, Klebsiella pneumoniae, Escherichia coli, Bacillus megaterium and Staphylococcus aureus. …”
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Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy by Weijian Zhu, Qiang Yi, Zheng Chen, Jiaqi Wang, Kui Zhong, Xinting Ouyang, Kuan Yang, Bowei Jiang, Jianing Zhong, Jinghua Zhong

“…By stabilizing RAD18, MAGEA4 facilitates the recruitment of Y-family DNA polymerases, enabling cells to continue replication under DNA damage conditions and thus supporting cancer cell survival. MAGEA4-based TCR-T cell therapy and cancer vaccines show clinical potential. …”
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The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide by Guang Tan, Xin Zhang, Hongbo Feng, Haifeng Luo, Zhongyu Wang

“…This study is to investigate the role of the CIKs cocultured with K-ras-DCs in killing of pancreatic cancer cell lines, PANC-1 (K-ras+) and SW1990 (K-ras−). …”
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1H and 13C NMR Assignments of Cytotoxic 3S-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid from the Leaves of Cichorium endivia by Fu-Xin Wang, An-Jun Deng, Jin-Feng Wei, Hai-Lin Qin, Ai-Ping Wang

“…Cytotoxicity of this isolated compound against HCT-8 and HepG2 human cancer cell lines was evaluated for the first time, with moderate activities being found.…”
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Application of evolutionary games to modeling carcinogenesis by Andrzej Swierniak, Michal Krzeslak

“…We review a quite large volume of literature concerning mathematical modelling of processes related to carcinogenesis and the growth of cancer cell populations based on the theory of evolutionary games. …”
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Ultra-compact quintuple-band terahertz metamaterial biosensor for enhanced blood cancer diagnostics. by Musa N Hamza, Mohammad Tariqul Islam, Sunil Lavadiya, Iftikhar Ud Din, Bruno Sanches, Slawomir Koziel, Syeda Iffat Naqvi, Ali Farmani, Md Shabiul Islam

“…However, accurate diagnosis is challenging due to the inherent similarities between normal and cancerous cells. Although various techniques are available for blood cancer identification, high-frequency imaging techniques have recently shown promise, particularly for real-time monitoring. …”
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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

“…These extracts were comparatively non-toxic to the normal human keratinocyte cell line, HaCaT, indicating its selective toxicity to cancerous cells. The cytomorphological changes associated with the chloroform extract and AO/EB dual staining indicated apoptotic cell death. …”
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Investigating the Medicinal Potential of Lavatera cashmeriana Leaf Extract: Phytochemical Profiling and In Vitro Evaluation of Antimicrobial, Antioxidant, and Anticancer Activities by Mohmmad Ashaq Sofi, Mohd Abass Sofi, Anima Nanda, Kasi Thiruvengadam, B. K. Nayak

“…The 2,2-diphenyl-1-picrylhydrazyl assay was conducted to assess antioxidant capabilities, while cytotoxicity against the A549 cancer cell line was determined via the MTT assay. GC-MS analysis identified ten different compounds, with phytol, 1-Eicosanol, and 2,6,10-trimethyl,14-ethylene-14-pentadecne being the most prevalent. …”
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