Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity by Binbin Liu, Yumo Xie, Yu Zhang, Guannan Tang, Jinxin Lin, Ze Yuan, Xiaoxia Liu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

“…Finally, we found dynamic change of epigenetic heterogeneity based on MeHEG score in cancer cells under the treatment of therapeutic drugs. …”
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Nestin Forms a Flexible Cytoskeleton by Means of a Huge Tail Domain That Is Reversibly Stretched and Contracted by Weak Forces by Ayana Yamagishi, Rina Tokuoka, Kazuki Imai, Mei Mizusawa, Moe Susaki, Koki Uchida, Saku T. Kijima, Akira Nagasaki, Daijiro Takeshita, Chiaki Yoshikawa, Taro Q. P. Uyeda, Chikashi Nakamura

“…It is also expressed in high-grade cancer cells, forming copolymerized filaments with vimentin. …”
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SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway by Yuwen Gong, Dongyang Gao, Yibo Shi, Guangrui Fan, Xiaoquan Yu, Enguang Yang, Hui Cheng, Junqiang Tian, Hui Ding, Shanhui Liu, Shengjun Fu, Yan Tao, Yuan Shui, Liang Cheng, Lanlan Li, Zhiping Wang

“…SRC activates hexokinase2 which up-regulates glycolysis and especially the pentose phosphate pathway that leading to increased nucleotide synthesis and NADPH production which can neutralize reactive oxygen species (ROS) induced by cisplatin, thereby protecting bladder cancer cells from cisplatin-induced DNA damage. This phenomenon was effectively reversed by knockout of SRC and inhibition of SRC activity by the SRC inhibitor, eCF506. …”
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Anticancer Activity of Asiatic Acid from Centella Asiatica: A Comprehensive Systematic Review of In Vitro and In Vivo Studies by Fiki Muhammad Ridho, Panggih Fahrudin, Andika Julyanto Syachputra, Iren Angelia Aruan, Kamailiya Ulfah, Alfi Syahri

“…Based on the findings in the reviewed articles, we report that AsA, a triterpene derived from C. asiatica, exhibits anticancer effects demonstrated both in various cancer cell lines and in cancer cell-induced animal model, through several mechanisms, including anti-inflammatory effects, antioxidant effects, inhibition of cell proliferation, inhibition of invasion and migration, and induction of apoptosis and autophagy. …”
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Computational identification of anti-cancer compounds targeting the RNA-binding domain of human FOX-1 protein (RBFOX1) by Muhammad Tahir ul Qamar, Pablo Sanz-Jimenez, Shaima Rabeea Banoon, Xi-Tong Zhu, Fahad M. Aldakheel, Nahlah Makki Almansour, Leen A. Aldaiji, Wafa Abdullah I. Al-Megrin, Faisal Ahmad

“…The overexpression of this gene correlates with the motility of cancer cells, their ability to invade surrounding tissues. …”
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A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser by Shengsheng Cui, Xinni Pan, Shanshan Fan, Cheng Cao, Yingao Jiao, Yanfei Fu, Jiaqi Niu, Shujin Lin, Jingmao Lao, Yanlei Liu

“…Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external light irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by the photothermal conversion efficiency of the material. …”
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Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression by Elisa Carouge, Clémence Burnichon, Martin Figeac, Shéhérazade Sebda, Nathalie Vanpouille, Audrey Vinchent, Marie‐José Truong, Martine Duterque‐Coquillaud, David Tulasne, Anne Chotteau‐Lelièvre

“…ETS gene fusions, in particular, have the ability to induce the migratory and invasive properties of prostate cancer cells, whereas MET receptor, through its signalling cascades, is able to activate transcription factor expression. …”
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The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa by Hadisaputri YE, Nurhaniefah AA, Mutakin M, Hendriani R, Rezano A, Sopyan I, Yusnaini Y, Asikin Y, Abdulah R

“…Previous analysis showed the cytotoxic impact of Callyspongia aerizusa (C. aerizusa) extract containing ergost-22-en-3-one and ergost-7-en3-ol against A549 lung cancer cells, with an IC50 value of 9.38 μg/mL. However, the extract did not have cytotoxicity towards Het-1A esophagus epithelial cells. …”
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Characterization of Listeria monocytogenes strains isolated from soil under organic carrot farming by Maciej Nowak, Zbigniew Paluszak, Natalia Wiktorczyk-Kapischke, Katarzyna Grudlewska-Buda, Anna Budzyńska, Joanna Skonieczna-Kurpiel, Ewa Wałecka-Zacharska, Monika Huse-Kutowska, Krzysztof Skowron

“…However, invasiveness of less than 1% was demonstrated for three strains, and strain 13 showed no ability to invade HT-29 human colon cancer cells. The level of coaggregation between the tested strains and S. …”
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SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer by Lutfi H. Alfarsi, Rokaya El Ansari, Busra Erkan, Ali Fakroun, Madeleine L. Craze, Mohammed A. Aleskandarany, Kiu Wai Cheng, Ian O. Ellis, Emad A. Rakha, Andrew R. Green

“…Abstract Cancer cells exhibit altered metabolism, often relying on glutamine (Gln) for growth. …”
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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…We engineered an antibody-dependent cellular cytotoxicity (ADCC) enhanced MICA/B monoclonal antibody, AHA-1031, which prevents ligand shedding without interfering with binding to natural killer group 2D while targeting cancer cells via superior ADCC. We performed in vitro assays using ELISA and flow cytometry-based assays to confirm that our antibody potently binds to and stabilizes MICA/B expression across lung cancer and other solid tumor cell lines. …”
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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…Its wide-ranging involvement in cellular metabolism and epigenetic control has been demonstrated by the discovery of particular lactylation sites on histones in various cell types, including cancer cells.…”
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Targeting estrogen-regulated system xc − promotes ferroptosis and endocrine sensitivity of ER+ breast cancer by Jiawei Cao, Tong Zhou, Tao Wu, Rixu Lin, Ju Huang, Dejin Shi, Jiawei Yu, Yinrui Ren, Changrui Qian, Licai He, Guang Wu, Zhixiong Dong, Shaofei Yuan, Haihua Gu

“…Moreover, SLC7A11 and SLC3A2 levels were elevated in endocrine-resistant breast cancer cells and tumors. Importantly, the system xc − inhibitor Sorafenib or Imidazole ketone erastin effectively inhibited the growth of tamoxifen-resistant breast cells in vitro and in vivo. …”
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UGCG promotes chemoresistance and breast cancer progression via NF-κB and Wnt/β-catenin pathway activation by Li Long, Lei Wang, Yiran Liang, Fangzhou Ye, Yuhan Jin, Dan Luo, Xiaoyan Li, Yajie Wang, Yaming Li, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Qifeng Yang

“…Gain- and loss-of-function experiments demonstrated that UGCG enhanced the proliferation, metastasis, and stemness of breast cancer cells. Furthermore, treatment with paclitaxel or docetaxel resulted in increased UGCG expression, which in turn reduced chemotherapy-induced cell apoptosis and improved drug resistance and metastatic capabilities. …”
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Influence of urokinase gene-knockout in C57BL/6-PlautmI. IBugThisPlau6FDhu/GFDhu mice on growth factors in malignant melanoma by E. M. Frantsiyants, I. V. Kaplieva, I. V. Neskubina, V. A. Bandovkina, L. K. Trepitaki, E. I. Surikova, N. D. Cheryarina, L. A. Nemashkalova, N. S. Lesovaya

“…Нigh levels of IGF1 in tissues of all uPA gene-knockout mice (males: in tumors by 1.4 times, in perifocal tissues by 2.6 times, in the skin by 3.6 times; females: in tumors by 2.6 times, in perifocal tissues by 25.0 times, in the skin by 13.9 times, compared to С57 ВL/6 mice) could maintain the metastatic phenotype of cancer cells (in females) or hiher proliferative activity of melanoma cells (in males). …”
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S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling by Liuyuan Xia, Xin Guo, Dong Lu, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin, Xin Luan, Weidong Zhang

“…Although significant progress has been made in understanding the crosstalk between cancer cells and CAFs, many underlying mechanisms remain unclear. …”
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Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies by Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi

“…The effect of the Fc-component of anti-TIGIT on NK-cell fratricide was determined by co-culturing WT and TIGIT KO NK cells with Fc-active and Fc-inactive anti-TIGIT.Results TIGIT KO increased the cytotoxicity of NK cells against multiple cancer cell lines including spheroids. TIGIT KO NK cells upregulated mTOR complex 1 (mTORC1) signaling and had better metabolic fitness with an increased basal glycolytic rate when co-cultured with cancer cells compared with WT NK cells. …”
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Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody by Liqiu Ma, Yang Li, Yoshimitsu Sakamoto, Lin Xie, Saaya Suzuki, Yukari Yoshida, Li Sui, Gang Guo, Jialing Wen, Wangcai Ren, Kazuhiro Kakimi, Kensuke Osada, Akihisa Takahashi, Takashi Shimokawa

“…Materials and methods: Murine cancer cells (colon carcinoma Colon-26 cells for experiments and osteosarcoma LM8 cells for verification) were grafted into both sides of the hind legs of syngeneic mice. …”
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NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

“…However, there is a paucity of experimental studies specifically addressing the relationship between NALCN and immune cell infiltration in gastric cancer (GC).MethodsThe expression levels of NALCN in tumor tissues, peripheral blood and gastric cancer cells lines from patients with GC were assessed using RNA sequencing, immunohistochemistry (IHC) staining and RT-qPCR. …”
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Biochemical mechanisms and molecular interactions of vitamins in cancer therapy by Abdullahi T. Aborode, Isreal A. Onifade, Mercy M. Olorunshola, Gladys O. Adenikinju, Ibude J. Aruorivwooghene, Adeboboye C. Femi, Osasere Jude-Kelly Osayawe, Abraham Osinuga, Ebenezer A. Omojowolo, Adekunle F. Adeoye, Segun Olapade, Ibrahim O. Adelakun, Ogundepo D. Moyinoluwa, Oluwatosin M. Adeyemo, Godfred Y. Scott, Ruth A. Ogbonna, Emmanuel A. Fajemisin, Omama Ehtasham, Soyemi Toluwalashe, Adetolase A. Bakre, Ridwan O. Adesola, Seto C. Ogunleye, Nnenna R. Anyanwu, Terungwa H. Iorkula

“…However, the reported findings are inconsistent, with limited information on the biochemical and molecular interactions of different vitamins in various cancer cells. Importantly, the presence of vitamin receptors in tumor cells suggests that vitamins play a significant role in the molecular and biochemical interactions in cancers. …”
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