Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors by Shivangi Sharma, Sadashivamurthy Shamanth, Humaira Siddiqua, Laijau Goyary, Kunigal S. Sagar, Susmita Kumari, Divya Sathees, Gudapureddy Radha, Bibha Choudhary, Sathees C. Raghavan, Kempegowda Mantelingu

“…Antiapoptotic protein BCL2 is known to be upregulated in several cancer cells and therefore, it is an excellent target for cancer therapy. …”
Get full text

Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9 by Cancan Zhou, Zhengyuan Feng, Weikun Qian, Zeen Zhu, Ruiqi Cao, Qiqi Wang, Wunai Zhang, Rujuan Liu, Shuai Wu, Jie Hao, Zheng Wang, Qingyong Ma, Zheng Wu, Xuqi Li

“…SREBP1 inhibition decreased SOX9 expression in both acinar cells and pancreatic cancer cells. Indeed, we identified SREBP1 binding sites in the SOX9 promoter region and reported that SOX9 is transcriptionally regulated by SREBP1. …”
Get full text

MicroRNA-21 as a biomarker in terminal stage oral squamous cell carcinoma (OSCC) in the South Indian population by Chevuru Sai Shreya Reddy, Ashikha Shirin Usman P.P, Dhanraj M. Ganapathy, Ameya K.P., Durairaj Sekar

“…Level of expression of genes in both cancer cells and normal cells are also analysed using graphical method. …”
Get full text

Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer by Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant, Rushikesh Joshi, Sachin Mishra, Anchala Pandey, Dimple Notani, Sanjeev Shukla

“…Specifically, disrupting the HIF1α-CTCF-COL5A1exon64A axis through the dCas9-DNMT3A system alleviates the EMT in hypoxic cancer cells and may represent a novel therapeutic target in breast cancer.…”
Get full text

SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells by Melissa Bernhardt, Anne Rech, Marion Berthold, Melina Lappe, Jan-Niklas Herbel, Florian Erhard, Annette Paschen, Bastian Schilling, Bastian Schilling, Andreas Schlosser

“…It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. To precisely determine how changes in cellular processes, such as those induced by drug treatment, affect the immunopeptidome, quantitative immunopeptidomics approaches are essential.MethodsTo meet this need, we developed a pulsed SILAC-based method for quantitative immunopeptidomics. …”
Get full text

Effects of Adipose-tissue Derived Mesenchymal Stem Cells on PBMCs in Co-culture with HeLa Cell Line by Maryam Dorfaki, mahdi ghatrehsamani, fahimeh Lavi Arab, Mona Roozbehani, Majid Khoshmirsafa, Reza Falak, Fatemeh Keshavarz, Fatemeh Faraji

“…Conclusion: These data showed that adipose-derived MSCs can stimulate the proliferation and survival of PBMCs and enhance the apoptosis of HeLa cells, indicating their potential as immunomodulatory therapy for cervical cancer cells. However, further research is required to fully understand the underlying mechanisms and optimize therapeutic approaches involving PBMCs and MSCs.…”
Get full text

Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors by Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song

“…Since human adipose tissue-derived stem cells (hASCs) are locally adjacent to breast cancer cells and might directly interact with tumor cells, we investigated whether CAFs may originate from hASCs. …”
Get full text

Synthesis, X-Ray Crystal Structures, and Preliminary Antiproliferative Activities of New s-Triazine-hydroxybenzylidene Hydrazone Derivatives by Assem Barakat, Fardous F. El-Senduny, Zainab Almarhoon, Hessa H. Al-Rasheed, Farid A. Badria, Abdullah Mohammed Al-Majid, Hazem A. Ghabbour, Ayman El-Faham

“…The preliminary antiproliferative activities for the synthesized compounds were tested against two different cancer cell lines including breast cancer (MCF-7) and colon cancer (HCT-116). …”
Get full text

Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity by Tutku Tunç, Ceylan Hepokur, Afşin Kari̇per

“…We thought that paclitaxel-loaded silver nanoparticles (AgNPs-PTX) were the right carrier to target cancer cells. We also carried out antimicrobial activity experiments as systems formed with nanoparticles have been shown to have antimicrobial activity. …”
Get full text

Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers by Bill Liao, Christine Tumanut, Lin Li, Adam Corper, Dilip Challa, Alex Chang, Hydari Begum, Elinaz Farokhi, Catherine Woods, Xiaomin Fan

“…Cell engager antibody formats that recruit and activate NK cells more effectively have emerged as a promising immunotherapy approach to target cancer cells through more effective antibody-dependent cell-mediated cytotoxicity (ADCC). …”
Get full text

Biosynthesis and health promoting traits of green synthesized cobalt oxide nanoparticles by Raghda Moawad, Yasmine Abdallah, Mohamed Mohany, Salim S. Al-Rejaie, Sinisa Djurasevic, Mohamed Fawzy Ramadan, Ahmed Bakr Mousa

“…In vitro traits of green-synthesized CoOnps were studied on ovarian cancer cells (SKOV3) using a Sulforhodamine B (SRB) method. …”
Get full text

Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α by Daisuke Umeda, Akikazu Harada, Daisuke Motooka, Shinichiro Tahara, Masako Kurashige, Kansuke Kido, Tsuyoshi Takashima, Hiroki Kiyokawa, Koto Ukon, Takahiro Matsui, Shinji Matsumoto, Yasushi Shintani, Daisuke Okuzaki, Akira Kikuchi, Satoshi Nojima, Eiichi Morii

“…MPC is composed of small clusters of cancer cells exhibiting inverted polarity. However, the mechanism underlying its formation is poorly understood. …”
Get full text

Synthetic Retinoid Sulfarotene Selectively Inhibits Tumor‐Repopulating Cells of Intrahepatic Cholangiocarcinoma via Disrupting Cytoskeleton by P‐Selectin/PSGL1 N‐Glycosylation Bloc... by Xiaojing Du, Zhuoran Qi, Sinuo Chen, Jinlan Wu, Ye Xu, Sunkuan Hu, Zhijie Yu, Jiayun Hou, Yuan Fang, Jinglin Xia, Xin Cao

“…Eliminating stem cell‐like cancer cells is an extremely promising but challenging strategy for treating ICC. …”
Get full text

Novel protein-based prognostic signature linked to immunotherapeutic efficiency in ovarian cancer by Shuo-Fu Chen, Liang-Yun Wang, Yi-Sian Lin, Cho-Yi Chen

“…The co-activation of the TGF-β pathway and cancer-associated fibroblasts could impair the ability of cytotoxic T cells to eliminate cancer cells, leading to poor outcomes in the high-risk group. …”
Get full text

Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer by Lijuan Wang, Guihua Jin, Chenchen He, Xijing Guo, Xia Zhou, Meng Li, Xia Ying, Le Wang, Huili Wu, Qing Zhu

“…Gαs expression was localized in nuclear and cytoplasm in prostate cancer cells and downregulated in metastatic PCa compared to localized PCa and BPH (P<0.001). …”
Get full text

Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment by Lee YH, Huang CY

“…After 5 min of NIR exposure and 24 h of in vitro culture, ICFESs encapsulating ≥ 10/10 μM [ICG]/[CPT] effectively killed more than 70% of the cancer cells, inducing greater mortality than that caused by a 4-fold higher dose of CPT alone. …”
Get full text

Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications by Hao Peng, Zheng Chao, Zefeng Wang, Xiaodong Hao, Zirui Xi, Sheng Ma, Xiangdong Guo, Junbiao Zhang, Qiang Zhou, Guanyu Qu, Yuan Gao, Jing Luo, Zhihua Wang, Jing Wang, Le Li

“…In this review, we delved into the underlying biomechanical mechanisms and the resulting intricate biological meaning in the TME, focusing mainly on the extracellular matrix, the stiffness of cancer cells, and immune synapses. We also summarized the methodologies employed for biomechanical research and the potential clinical translation derived from current evidence. …”
Get full text

Calcium Activation of the Androgen Receptor in Prostate Cells by Zeina W. Sharawi, Sawsan M. Khatrawi, Qiaochu Wang, Hongzhao Zhou, Kedra Cyrus, Gai Yan, Becky Hoxter, Bassem R. Haddad, Mary Beth Martin

“…The results of this study show that calcium activates AR and increases cell growth and that calcium channels are overexpressed in hormone-responsive and hormone-resistant prostate cancer cells. Taken together, the results suggest a novel role of calcium in the castration-resistant phenotype.…”
Get full text

Evaluation of Tumor Viability for Primary and Bone Metastases in Metastatic Castration-Resistant Prostate Cancer Using Whole-Body Magnetic Resonance Imaging by Hiromichi Iwamura, Yasuhiro Kaiho, Jun Ito, Go Anan, Nozomi Satani, Tomonori Matsuura, Ryo Tamura, Kazuhiro Murakami, Kaneki Koyama, Makoto Sato

“…Prostate needle biopsy demonstrated viable prostate cancer cells from 10 of 12 cores. In contrast, CT-guided needle biopsy from bone metastasis of the lumbar vertebra revealed no malignant cells. …”
Get full text

The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics by Szonja Polett Pósa, Éva Saskői, Lili Bársony, Lőrinc Pongor, Fanni Fekete, János Papp, Anikó Bozsik, Attila Patócs, Henriett Butz

“…Abstract The glucocorticoid receptor (GR) plays a significant role in breast cancer cell behaviour, although data on its effects are conflicting. …”
Get full text