Fragile Histidine Triad (FHIT) Suppresses Proliferation and Promotes Apoptosis in Cholangiocarcinoma Cells by Blocking PI3K-Akt Pathway by Qiang Huang, Zhen Liu, Fang Xie, Chenhai Liu, Feng Shao, Cheng-lin Zhu, Sanyuan Hu

“…Fragile histidine triad (FHIT) is a tumor suppressor protein that regulates cancer cell proliferation and apoptosis. However, its exact mechanism of action is poorly understood. …”
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Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein by Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam

“…The results showed that PreS1-Cur-CM11-CS NPs are capable of targeted and specific drug release against HepG2 cancer cells and have significant potential to fight this cancer. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…ABSTRACT Background and Aims Sensitivity to immune checkpoint inhibitor (ICI) therapy depends in part on the genetic and epigenetic makeup of cancer cells, and CD8 T‐lymphocytes that mediate immune responses. …”
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Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

“…CAR-T cells have demonstrated considerable efficacy in the targeted eradication of blood cancer cells, thereby stimulating substantial interest in the advancement of such therapeutic approaches. …”
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Research on Correlations of lncRNA ST7-AS1 with Progression and Therapeutic Targets of Esophageal Cancer by Xiao Lin, Sijia Sun, JiWen Zhang, Yan Cai, Quan Cheng

“…Silencing ST7-AS1 reduced the proliferation level of esophageal cancer cells, as did the migration and invasion levels. …”
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The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy by Ning Yang, Wen-jing Yun, Zheng-guo Cui, Hua-chuan Zheng

“…Additionally, the effects of GPR176 on ovarian cancer cell phenotypes were investigated.Results GPR176 expression positively correlated with elder age, clinicopathological staging, tumour residual status, and unfavourable survival of ovarian cancer, but negatively with purity loss, infiltration of B cells, and CD8+ T cells. …”
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Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy by Saber Imani, Xiaoyan Li, Keyi Chen, Mazaher Maghsoudloo, Parham Jabbarzadeh Kaboli, Mehrdad Hashemi, Mehrdad Hashemi, Saloomeh Khoushab, Saloomeh Khoushab, Xiaoping Li

“…We discuss how accurate predictions of neoantigen structures guide the design of mRNA sequences that effectively target immune and cancer cells. Furthermore, we examine AI-driven approaches that optimize mRNA-LNP formulations, enhancing delivery and stability. …”
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NEIL3 Mediates Lung Cancer Progression and Modulates PI3K/AKT/mTOR Signaling: A Potential Therapeutic Target by Hongbo Huang, Qingwang Hua

“…The proliferative abilities of lung cancer cells were evaluated by the CCK8 and colony formation assays while their invasive and migration abilities were assessed by the transwell and wound healing assays. …”
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Orphan nuclear receptor NR2E3 is a new molecular vulnerability in solid tumors by activating p53 by Yidan Wang, Todd G. Kroll, Linhui Hao, Zhi Wen

“…Here, we demonstrate that the full-length protein isoform of NR2E3 instead of its short isoform activates wild-type p53 and is capable of rescuing certain p53 mutations in various cancer cell lines. Importantly, we observe a higher frequency of NR2E3 mutations in three solid tumors compared to the reference population, highlighting its potential significance in tumorigenesis. …”
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Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis by Liu Haibo, Luo Shicheng, Sha Xiaofeng, Chen Zhiping, Yang Dongdong

“…Additionally, HOXA6 or ZBTB12 overexpression in CAFs enhanced gastric cancer cell malignancy, which was reversed after astragaloside IV treatment. …”
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Flavonoids of Rosa rugosa Thunb. inhibit tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells by Zhiguo Zhang, Meilin Wang, Shu Xing, Chen Zhang

“…Conclusion, this study found that rose flavonoids had a certain inhibitory effect on proliferation and metastasis of human liver cancer cells HepG2, indicating the application of rose flavonoids in preventing and treating of liver cancer.…”
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Nanomechanical characterization of soft nanomaterial using atomic force microscopy by Chi-Dat Lam, Soyeun Park

“…Chemical force microscopy, single-molecule force spectroscopy, and single-cell force spectroscopy are primary AFM methods that provide a comprehensive view of such properties through retract curve analysis.Furthermore, this paper, structured into key thematic sections, also reviews the exemplary application of AFM across multiple scientific disciplines. Notably, cancer cells are softer than healthy cells, although more sophisticated investigations are required for prognostic applications. …”
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Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2 by Bin Ke, Ting Wei, Yuanyuan Huang, Yuxin Gong, Gang Wu, Junfang Liu, Xiaoting Chen, Lin Shi

“…Treatment with cisplatin (DDP) is one of the standard therapies used to treat non-small-cell lung cancer (NSCLC) and fundamentally causes resistance in cancer cells, which eventually poses as an obstacle to the efficacy of chemotherapy in NSCLC. …”
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Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc by Bin Chen, Jing Yu, Qianqian Wang, Yuanyuan Zhao, Li Sun, Changgen Xu, Xiangdong Zhao, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu

“…Additionally, hBM-MSC-CM enhanced the migration and glucose uptake of gastric cancer cells. In vivo studies showed that JQ1 inhibited hBM-MSC-CM-induced gastric cancer growth. …”
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PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells by Kimiyoshi Yano, Megumi Kato, Syoju Endo, Taichi Igarashi, Ryoga Wada, Takashi Kohno, Astrid Zimmermann, Heike Dahmen, Frank T. Zenke, Bunsyo Shiotani

“…Elevated RS levels increase the vulnerability of cancer cells to ataxia telangiectasia and Rad3-related kinase inhibitors (ATRis). …”
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Robust genome editing activity and the applications of enhanced miniature CRISPR-Cas12f1 by Soo-Ji Park, Sungjin Ju, Won Jun Jung, Tae Yeong Jeong, Da Eun Yoon, Jang Hyeon Lee, Jiyun Yang, Hojin Lee, Jungmin Choi, Hyeon Soo Kim, Kyoungmi Kim

“…Furthermore, we demonstrate that eCas12f1 efficiently induces apoptosis in cancer cells and is compatible with base editing and regulation of gene expression, verifying its high utility and applicability in gene therapy research.…”
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Formulation and evaluation of hyaluronic acid and adipic acid dihydrazide modified graphene quantum dot-based nanotherapeutics for paclitaxel-targeted delivery in breast cancer by Dilip O. Morani, Pravin O. Patil

“…Additionally, cellular uptake research has shown that MCF7 cancer cells absorbed more PAC@HA-ADH-GQDs than GQDs alone due to the presence of targeting agent HA. …”
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Tannic acid elicits differential gene regulation in prostate cancer apoptosis by Kandir Sinan, Karakurt Sevtap, Gökçek-Saraç Çiğdem, Karakurt Serdar

“…These findings highlight tannic acid’s ability to induce apoptosis in prostate cancer cells through pro-apoptotic pathways. This study concludes that tannic acid selectively inhibits prostate cancer cell growth.…”
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Marine Macroalgae Display Bioreductant Efficacy for Fabricating Metallic Nanoparticles: Intra/Extracellular Mechanism and Potential Biomedical Applications by Sabiha Mahmood Ansari, Quaiser Saquib, Valeria De Matteis, Hend Awad Alwathnani, Sulaiman Ali Alharbi, Abdulaziz Ali Al-Khedhairy

“…Bioactive constituents from the above resources have been found on the green metallic NPs, which has demonstrated their efficacies as prospective antibiotics and anti-cancer agents against a range of human pathogens and cancer cells. Moreover, these NPs can be characterized for the size, shapes, functional groups, surface properties, porosity, hydrodynamic stability, and surface charge using different characterization techniques. …”
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Preparation, characterisation, and in vitro cancer‐suppression function of RNA nanoparticles carrying miR‐301b‐3p Inhibitor by Junjie Zhao, Niu Niu, Fan Yang, Haitao Liu, Weibo Qi

“…Such nanomaterials were effectively internalized by cancer cells, with normal cell activity intact. Cancer cell proliferation, invasion, and migration were suppressed, and DDP sensitivity was enhanced, causing DNA damage and facilitating apoptosis of DDP‐resistant cells. …”
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