Evaluation of Platelet Parameters in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma in a Background of Oral Submucous Fibrosis by Packiaraj Selvajothi Ranjitham, Subramanian Kuzhali, Muthu Ponnuswamy Sumathy, Santiago Gnandeepam

“…The interaction between cancer cells and platelets is a well-established phenomenon. …”
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Evaluating Medicinal Plants for Anticancer Activity by Elisha Solowey, Michal Lichtenstein, Sarah Sallon, Helena Paavilainen, Elaine Solowey, Haya Lorberboum-Galski

“…Our hypothesis was that whole plant extracts selected according to ethnobotanical sources of historical use might contain multiple molecules with antitumor activities that could be very effective in killing human cancer cells. This study examined the effects of three whole plant extracts (ethanol extraction) on human tumor cells. …”
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Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression by Divya Khandige Sharma, Kamiko Bressler, Harshil Patel, Nirujah Balasingam, Nehal Thakor

“…In particular, translation of mRNAs specific to angiogenesis, tumor development, and apoptosis is altered during physiological and pathophysiological stress conditions. In cancer cells, the expression and functions of eIFs are hampered, resulting in the inhibition of global translation and enhancement of translation of subsets of mRNAs by alternative mechanisms. …”
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Design, Synthesis and Pharmacological Screening of β-Amino-, Thiadiazole/Thiadiazine-Phosphonate Based Triazole Motifs as Antimicrobial/Cytotoxic Agents by Abdou Wafaa M., Ganoub Neven A., Sabry Eman

“…The results showed that all synthesized compounds reflected remarkable antitumor activity against breast (especially MDA-MB-231/ATCC and BT-549), and prostate carcinoma cell lines (PC-3 and DU-145), whereas a moderate to good effect on ovarian and liver cancer cells was observed.…”
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Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer by Marisa Shiina, Lilly Y. W. Bourguignon

“…We determined that human head and neck cancer cells (HSC-3 cell line) contain a subpopulation displaying cancer stem cell (CSC) properties and are very tumorigenic. …”
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Effects of silkworm pupa protein on apoptosis and energy metabolism in human colon cancer DLD-1 cells by Xiaojiao Ji, Jing Wang, Aijin Ma, Duo Feng, Yue He, Wenjie Yan

“…Objective: To investigate the effects of silkworm pupa (Bombyx mori) protein (SPP) on cell proliferation, apoptosis and energy metabolism in human colon cancer cells DLD-1. Methods: CCK-8 was used to detect cell proliferation rate after 72 h of cell culture for the control group (normal cultured DLD-1 cells) and SPP dose groups; Annexin-V/PI was applied to observe cell apoptosis; XFe24 Extracellular Flux Analyzer was used to detect cell mitochondrial respiratory function and glycolytic function. …”
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Asymptotic analysis of mathematical model describing a new treatment of breast cancer using AZD9496 and palbociclib by Ophir Nave, Ophir Nave

“…The mathematical model that described the interaction between the cancer cells, the treatment, and the immune system cells includes a system of nonlinear ordinary differential equations of the firs order. …”
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Andrographolide suppresses cervical cancer progression by targeting angiogenesis and inducing apoptosis in a CAM-PDX model by Wanwan Zou, Jun Lou, Yun Yi, Yiming Cui, Xiaoyan Chu

“…Immunohistochemical analysis revealed that AND downregulated key proteins associated with cancer cell proliferation and survival, including Ki67, B-cell lymphoma 2 (BCL-2), and Erythroblast transformation-specific-related gene (ERG). …”
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KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency by Samah W. Awwad, Colm Doyle, Josie Coulthard, Aldo S. Bader, Nadia Gueorguieva, Simon Lam, Vipul Gupta, Rimma Belotserkovskaya, Tuan-Anh Tran, Shankar Balasubramanian, Stephen P. Jackson

“…Abstract ATR plays key roles in cellular responses to DNA damage and replication stress, a pervasive feature of cancer cells. ATR inhibitors (ATRi) are in clinical development for treating various cancers, including those with high replication stress, such as is elicited by ARID1A deficiency, but the cellular mechanisms that determine ATRi efficacy in such backgrounds are unclear. …”
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Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment by Ananda Kishore Mukherjee, Subhajit Dutta, Ankita Singh, Shalu Sharma, Shuvra Shekhar Roy, Antara Sengupta, Megha Chatterjee, Soujanya Vinayagamurthy, Sulochana Bagri, Divya Khanna, Meenakshi Verma, Dristhi Soni, Anshul Budharaja, Sagar Kailasrao Bhisade, Vivek Anand, Ahmad Perwez, Nija George, Mohammed Faruq, Ishaan Gupta, Radhakrishnan Sabarinathan, Shantanu Chowdhury

“…Here, we observed that interleukin-1 signalling is telomere-length dependent in cancer cells. Mechanistically, non-telomeric TRF2 (telomeric repeat binding factor 2) binding at the IL-1-receptor type-1 (IL1R1) promoter was found to be affected by telomere length. …”
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Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins by Yan Wang, Xin Qian, Yubo Wang, Caiyuan Yu, Li Feng, Xiaoyan Zheng, Yaya Wang, Qiuhong Gong

“…Prolonging the half‐life of TRAIL in vivo; 6. Sensitizing cancer cells to overcome resistance to TRAIL treatment. …”
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Prognostic significance of right subdiaphragmatic washing cytology in patients with endometrial cancer by Takanori Yokoyama, Shinichi Okame, Mika Okazawa-Sakai, Etsuko Fujimoto, Yumi Hibino, Norihiro Teramoto, Kazuhiro Takehara

“…Abstract Cancer cells in the right subdiaphragmatic lavage may reflect peritoneal dissemination, but its prognostic significance is unknown. …”
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Shedding Light on the Prognostic and Predictive Value of Circulating Tumor DNA for Management of Patients with Early-Stage Colon Cancer by Rami Yanes MD, Turcin Saridogan MD, PhD, Vikram Gorantla MD, Abigail Overacre PhD, Ronan W. Hsieh MD, James Celebrezze MD, Tara Magge MD, Meghana Singhi MD, Anwaar Saeed MD, Amer H. Zureikat MD, Arvind N. Dasari MD, Ibrahim Halil Sahin MD

“…Circulating tumor DNA (ctDNA) is cell-free DNA originating from cancer cells and can be detected even in the absence of radiologically detectable disease among patients with colon cancer. …”
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Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges by Rachitha Puttasiddaiah, Nagaraj Basavegowda, Nityashree Kyathegowdanadoddi Lakshmanagowda, Vinay Basavegowda Raghavendra, Niju Sagar, Kandi Sridhar, Praveen Kumar Dikkala, Maharshi Bhaswant, Kwang-Hyun Baek, Minaxi Sharma

“…These methods seek to completely eradicate all cancer cells while having the fewest possible unintended impacts on healthy cell types. …”
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Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy by Ling Ding, Xiaoshan Wang, Qing Wu, Xia Wang, Qigang Wang

“…Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. …”
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Allelic and Genotypic Analysis of LncRNA ANRIL rs4977574 A/G Mutations in Oral Squamous Cell Carcinoma Patients: Insights into Tumor Characteristics and Genotypic Correlations by Mohammad Amin Amiri, Delara Amiri, Mohammad Javad Mokhtari, Fatemeh Lavaee, Mohammad Javad Fattahi, Abbas Ghaderi, Bijan Khademi

“…The results of our study indicate that rs4977574 A/G and its genotypes do not have any direct correlation with the presence of OSCC; however, its association with the smaller tumor size and the level of the cancer cells differentiation could imply its possible indirect role.…”
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miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 by Jiahui Mao, Lingxia Wang, Junying Wu, Yichun Wang, Huiyan Wen, Xueming Zhu, Bo Wang, Huan Yang

“…FBLN5 expression was significantly decreased in breast cancer cells and tumor tissues of breast cancer patients. …”
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The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers by Ehsan Shabani, Aida Hasanzadi, Omer Qutaiba B. Allela, Radhwan Abdul Kareem, Riyad E. Abed, Ali M. Ali Al-Nuaimi, Zainab H. Athab, Shiva Khodarahmi

“…One of the most noticeable metabolic abnormalities in cancer is lipid metabolism reprogramming, in which cancer cells dysregulate lipid metabolism to obtain sufficient energy, building blocks for cell membranes, and signaling molecules necessary for invasion, metastasis, proliferation, and survival. …”
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An Analytical Approach Differentiates Between Individual and Collective Cancer Invasion by Elad Katz, Wim Verleyen, Colin G. Blackmore, Michael Edward, V. Anne Smith, David J. Harrison

“…In conclusion, the combination of cognition network technology and Bayesian network analysis provides an insight into morphological variables associated with transition of cancer cells between invasion modes. We show that only two morphologically distinct modes of invasion exist.…”
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Chemotherapeutic hormesis induced by the tumor microenvironment in refractory ovarian cancer by Xuboya Chang, Satoshi Tamauchi, Atsushi Nakagawa, Wang Xinyuan, Kosuke Yoshida, Akira Yokoi, Nobuhisa Yoshikawa, Hiroaki Kajiyama

“…This study investigates the phenomenon of chemotherapeutic hormesis, wherein low doses of chemotherapeutic agents, such as cisplatin (CDDP) and paclitaxel (PTX), paradoxically stimulate rather than inhibit cancer cell proliferation. Our findings indicate that NOS3 ovarian cancer cells, particularly drug-resistant variants, exhibit enhanced proliferation when exposed to low concentrations of these drugs. …”
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