The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis by Chee Wai Wong, Danielle E. Dye, Deirdre R. Coombe

“…The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. …”
Get full text

Purification, structural elucidation, and in vitro antitumor effects of novel polysaccharides from Bangia fuscopurpurea by Jingna Wu, Xiaoting Chen, Kun Qiao, Yongchang Su, Zhiyu Liu

“…Counting Kit-8 assays revealed that BFP-3 significantly inhibited the proliferation of A2780, COC1, SKOV3, HO-8910, and OVCAR3 ovarian cancer cells in vitro, indicating that BFP-3 could have potential applications in the treatment of ovarian cancer.…”
Get full text

Investigation into the Effect of Aspartame on the Expression of p53 and BAX in Mouse Stomach Tissue by Angelique Cheryl, Aoife Mac Cooey

“…Evidence suggests that aspartame exposure may alter p53 and BAX gene expression, affecting apoptosis in cancer cells. This study aims to examine how aspartame exposure affects p53 and BAX gene expression in normal mouse stomach tissue, shedding light on cellular stress and apoptosis mechanisms. …”
Get full text

Peiminine Enhances Doxorubicin Cytotoxicity and Downregulates hsa-miR-106a-5p and hsa -miR-181a-5p in Human Gastric Adenocarcinoma Cells by Shirin Hedayati, Hossein Soltanzadeh, Hadi Esmaeili Gouvarchin Ghaleh, Zahra Hojjati Bonab, Akbar Ghorbani Alvanegh

“…Chemotherapy is the primary treatment, but some patients use herbal remedies, such as Peiminine from Fritillaria walujewii, for palliative care. Cancer cells can affect the expression of noncoding RNAs, like microRNA, which can then influence the expression of genes. …”
Get full text

Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers by A.N.K.V. Sravani, John Thomas

“…It enhances the ability of cancer cells' to self-renew and initiate tumors, while also increasing resistance to apoptosis and chemotherapy. …”
Get full text

Rheological Characterization and Printability of Sodium Alginate–Gelatin Hydrogel for 3D Cultures and Bioprinting by Mohan Kumar Dey, Ram V. Devireddy

“…The optimized 7% alginate and 8% gelatin blend demonstrated favorable printability, mechanical strength, and cell compatibility with MDA-MB-213 breast cancer cells, exhibiting high cell proliferation rates and minimal cytotoxicity over a 2-week culture period. …”
Get full text

M2 Macrophages Mediate the Resistance of Gastric Adenocarcinoma Cells to 5-Fluorouracil through the Expression of Integrin β3, Focal Adhesion Kinase, and Cofilin by Daniel Ngabire, Irvine Niyonizigiye, Maheshkumar Prakash Patil, Yeong-Ae Seong, Yong Bae Seo, Gun-Do Kim

“…In this study, we investigated the role of alternatively activated macrophages in the resistance of AGS gastric cancer cells to fluorouracil. THP-1 cells were polarized using recombinant human IL-4, then were cocultured with AGS cells treated with fluorouracil. …”
Get full text

E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects by Layla A. Al-Kharashi, Falah H. Al-Mohanna, Abdelilah Aboussekhra, Abdelilah Abousekhra

“…Indeed, E2F1-expressing fibroblasts were more efficient than their corresponding controls in enhancing the epithelial-to-mesenchymal transition and stemness processes in breast cancer cells both in vitro and in vivo. However, E2F1 knock-down normalized breast CAFs and suppressed their paracrine pro-carcinogenic effects. …”
Get full text

Downregulation of HBx Restrains Proliferation, Migration, and Invasion of HepG2 Cells by Chaoqun Huang, Wei Liu, Xiaochuan Zhao, Libin Zhao, Fuxiang Wang

“…In summary, our data illustrate that inhibition of HBx effectively suppressed proliferation and metastasis and induced apoptosis of liver cancer cells, which might be partially reversed by XB130. …”
Get full text

Relationship between Dyskerin Expression and Telomerase Activity in Human Breast Cancer by Lorenzo Montanaro, Maria Calienni, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Stefano Pileri, Davide Treré, Massimo Derenzini

“…In conclusion, our results indicated that, beside its effect on ribosome biogenesis, the levels of dyskerin in cancer cells modulate telomerase activity through the regulation of TERC levels, independently of TERT expression. …”
Get full text

Prostate-Specific Membrane Antigen-Based Therapeutics by Naveed H. Akhtar, Orrin Pail, Ankeeta Saran, Lauren Tyrell, Scott T. Tagawa

“…While initial anti-PSMA monoclonal antibodies were suboptimal, the development of monoclonal antibodies such as J591 which are highly specific for the external domain of PSMA has allowed targeting of viable, intact prostate cancer cells. Radiolabeled J591 has demonstrated accurate and selective tumor targeting, safety, and efficacy. …”
Get full text

Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells. by Napat Armartmuntree, Yingpinyapat Kittirat, Bundit Promraksa, Watcharin Loilome, Hasaya Dokduang, Anchalee Techasen, Pahol Sansomchai, Malinee Thanee, Thomas O'Connor, Phutthida Kongthitilerd, Sureerat Padthaisong

“…TC, a traditional remedy in Southeast Asia, exhibits anti-inflammatory and cytotoxic properties against cancer cells. Ethanol extraction of TC's rhizome was conducted, and antioxidant activities were assessed through various assays, including total phenolic and flavonoid contents, DPPH radical scavenging, and FRAP assays. …”
Get full text

A multiscale model for glioma spread including cell-tissue interactions and proliferation by Christian Engwer, Markus Knappitsch, Christina Surulescu

“…Our current accounting for two subpopulations of cells to accomodate proliferation according to the go-or-grow dichtomotyis an extension of the setting in [16].As in that paper, we assume that cancer cells use neuronal fiber tracts as invasive pathways. …”
Get full text

Immune Cell Profiling Reveals a Common Pattern in Premetastatic Niche Formation Across Various Cancer Types by Shigeaki Sugiyama, Kanae Yumimoto, Keiichi I. Nakayama

“…Materials and Methods We performed comprehensive flow cytometric analysis of lung and peripheral immune cells at three time points (early premetastatic, late premetastatic, and micrometastatic phases) for mice with subcutaneous implants of three types of cancer cells (breast cancer, lung cancer, or melanoma cells). …”
Get full text

Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression by Shankar Suman, Wendy K. Nevala, Alexey A. Leontovich, James W. Jakub, Liyi Geng, Sarah A. McLaughlin, Svetomir N. Markovic

“…The upregulation of Th2 cytokines in cancer cells is recognized for its involvement in suppressing anticancer immunity. …”
Get full text

Correlation between P-glycoprotein and CD34 Expressions in Leukemic Cells from De novo Acute Myeloid Leukemia by Yulia Nadar Indrasari, Yetti Hernaningsih, Aryati Aryati, Siprianus Ugroseno Yudho Bintoro, Atika Atika, Rosline Hassan

“…This contrasts with the lack of clarity on Pgp’s activity as an efflux pump in neoplastic or cancer cells. The association between Pgp and CD34 expression in adult patients with de novo AML was investigated in this study. …”
Get full text

DNA Cleavage, Cytotoxic Activities, and Antimicrobial Studies of Ternary Copper(II) Complexes of Isoxazole Schiff Base and Heterocyclic Compounds by Vijay Kumar Chityala, K. Sathish Kumar, Ramesh Macha, Parthasarathy Tigulla, Shivaraj

“…In vitro antitumor activity of Cu(II) complexes was assayed against human cervical carcinoma (HeLa) cancer cells and it was observed that few complexes exhibit good antitumor activity on HeLa cell lines. …”
Get full text

Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

“…Simultaneously, OVT leverages genetically engineered viruses to selectively destroy cancer cells and stimulate robust antitumor immune responses. …”
Get full text

Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects by Yufei Wang, Guangliang Li, Hanying Wang, Quan Qi, Xian Wang, Haiqi Lu

“…These therapies offer novel strategies for delivering targeted treatments to Nectin-4-expressing cancer cells, enhancing treatment efficacy and minimizing off-target effects. …”
Get full text

Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract of Annona muricata by Wisdom O. Iyanda-Joel, Olusayo B. Ajetunmobi, Shalom N. Chinedu, Emeka E. J. Iweala, Oluwatobi S. Adegbite

“…Uncontrolled cell proliferation hallmarks cancer and most cancer cells have developed multiple resistance to the drugs employed for their treatment. …”
Get full text