Microalgae: A Treasure Trove of Anticancer Nutraceuticals and Promising Therapeutic Mechanisms by Sajjad Masoumi, Maryam Zokaei, Ardavan Ahmadvand, Nogol Ghalamkarpour, Naghmeh Asadimanesh, Armin Azarimatin, Khashayar Fattah, Zahra Payandeh, Masoumeh Rostami, Afsaneh Farjami, Rajan Kumar Pandey, Mohsen Nabi-Afjadi

“…Carotenoids, including astaxanthin, have shown the ability to hinder the development of tumors and trigger programmed cell death (apoptosis) in several types of cancer cells. Moreover, studies have shown that phycocyanin, a blue pigment present in some species of microalgae, has properties that help reduce inflammation and combat cancer. …”
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Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer by Margit Egg, Thomas Kietzmann

“…WEMFs affect multiple cellular processes through mechanisms such as the radical pair mechanism (RPM), which alters reactive oxygen species (ROS) levels, mitochondrial function, and glycolysis, among others.This review explores the potential of WEMF in conjunction with reactive oxygen species as a cancer therapy, highlighting WEMFs selective targeting of cancer cells and its non-ionizing nature, which could reduce collateral damage compared to conventional treatments. …”
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Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects by Zhipeng Cao, Sadia Quazi, Sakshi Arora, Laura D. Osellame, Ingrid J. Burvenich, Peter W. Janes, Andrew M. Scott

“…Abstract Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance. …”
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Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game by Paqui G. Través, Alfonso Luque, Sonsoles Hortelano

“…In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells. Tumor suppressor genes have been traditionally linked to the regulation of cancer progression; however, a growing body of evidence indicates that these genes also play essential roles in the regulation of innate immunity pathways through molecular mechanisms that are still poorly understood. …”
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Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer by Jiangang Zhao, Jiahui Li, Hans A. Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

“…Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. …”
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Cellulose Based Nano-Scaffolds for Targeted Cancer Therapies: Current Status and Future Perspective by Li Y, Liu W, Wang Y, Lu S

“…Cellulose based nanomaterials like cellulose nanofibers, bacterial cellulose, cellulose nanocrystals and microcrystalline cellulose as delivery vehicles for targeted drug delivery to cancer cells are reviewed. This review elaborates on the synthesis, functionalization, and application strategies of these nanocarriers, and shows how they facilitate to improve drug stability, bioavailability and targeted delivery to tumor sites. …”
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In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? by Carlotta Mattioda, Claudia Voena, Gianluca Ciardelli, Clara Mattu

“…In the last decades, it was largely demonstrated that the tumor microenvironment significantly affects cancer cell proliferation and tumor response to treatment. …”
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Dynamics analysis and optimal control of a fractional-order lung cancer model by Xingxiao Wu, Lidong Huang, Shan Zhang, Wenjie Qin

“…This study presented a novel Caputo fractional-order lung cancer model aimed at analyzing the population dynamics of cancer cells under untreated conditions and different treatment strategies. …”
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Protocol to identify small-molecule inhibitors against cancer drug resistance by Juan Wei, She-Yu Zhang, Xue-Yuan Zhou, Yong Wei, Hao-Ran Jia, Qin Wu, Weihong Tan

“…Here, we present a high-throughput screening protocol to identify therapeutic small-molecule inhibitors against drug-resistant cancer cells. We detail the steps for constructing drug-resistant cell models, executing the chemical screening process, and performing data analysis and validation. …”
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Bacteria as Precision Tools for Cancer Therapy by Carmen Michán, José Prados, Juan‐Luis Ramos

“…This progress, along with recent insights into how cancer cells evade immune response, has prompted innovative therapeutic approaches. …”
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Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer by L. S. Franco, S. Arunachalam, A. Chauhan, S. A. Kareff, P. L. Hallenbeck

“…It is especially attractive given its selective expression on the surface of solid tumor cells and associated stromal cells, such as cancer stem cells, invasive cancer cells, and immune cells, such as macrophages, angiogenic endothelial cells, pericytes, and cancer-associated fibroblasts. …”
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AHNAK2: a potential diagnostic biomarker for pancreatic cancer related to cellular motility by Mohamed Zardab, Barts Pancreas Tissue Bank, Richard P. Grose, Hemant M. Kocher

“…This colocalization increased when cells were cultured on substrates such as Fibronectin and Collagen, as well as in hypoxia, and resulted in an augmented invasion of cancer cells. However, in cell lines with a vesicular AHNAK2 staining, such changes were not observed. …”
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Role of heat shock protein in radiation-induced effect and related potential clinical application by Ying Xu, Wentao Hu, Guangming Zhou

“…This phenomenon not only provides a mechanism for normal tissues to resist radiation damage, but also provides a strategy for cancer cells to reduce their sensitivity to radiation and escape treatment. …”
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Whole genome sequence of Streptomyces colonosanans strain MUSC 93JT isolated from mangrove forest in Malaysia by Hooi-Leng Ser, Jodi Woan-Fei Law, Wen-Si Tan, Wai-Fong Yin, Kok-Gan Chan

“…Displaying selective toxicity that kills only cancer cells, ectoine has showed its potential to be developed as therapeutic agents for humans. …”
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Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer by J. Kabzinski, A. Walczak, I. Majsterek

“…Using the knowledge obtained in the course of conducted experiments, we postulate consideration of Sirt3 as a target in the rising vulnerability of cancer cells during therapy and therefore increasing the effectiveness of cancer treatment.…”
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A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin by R. Foulady-Dehaghi, Sh. Sohrabnezhad, M. Hadavi

“…C-loaded hybrid nanostructure prepared via the solvent-free drug loading process displayed a high entrapment efficiency (35.96%) and improved release in the acidic environment specific to cancer cells (pH = 4.5: 36.8%, pH = 7.4: 15.27%). In conclusion, we illustrated the utility of C@DDS as an in vitro drug delivery system in MDA-MB-231 cells. …”
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Specific immunohistochemical expression of Mmp-26 in prostatic adenocarcinoma by ROMILDO LUCIANO DA SILVA, FRANCISCO LUÍS A. PAES, SANDRA MARIA S. DA SILVA, FABIANO SANTOS, EDUARDA S. DE SANTANA, JACINTO DA C. SILVA NETO

“…MMP-26 is expressed constitutively in the endometrium and some cancer cells of epithelial origin. However, there is a lack of studies on its expression on prostatic carcinoma. …”
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Differential Toxicity of DNA Adducts of Mitomycin C by Jill Bargonetti, Elise Champeil, Maria Tomasz

“…Evidence is reviewed that various adducts are capable of inducing different cell death pathways in cancer cells.This evidence is derived from a parallel study of MC and its derivatives 2,7-diaminomitosene (2,7-DAM) which is the main metabolite of MC and forms two mono-adducts with DNA, and decarbamoyl mitomycin C (DMC), which alkylates and cross-links DNA, predominantly with a chirality opposite to that of the DNA adducts of MC. 2,7-DAM is not cytotoxic and does not activate the p53 pathway while MC and DMC are cytotoxic and able to activate the p53 pathway. …”
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CD47/SIRPα axis: bridging innate and adaptive immunity by Sjoerd H van der Burg, Anneloes van Duijn, Ferenc A Scheeren

“…As CD47 is often overexpressed on cancer cells, treatments targeting CD47/SIRPα have been under active investigation and are currently being tested in clinical settings. …”
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Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer by Anita Thyagarajan, Zaid Sirhan, Ravi P. Sahu

“…The integration between the tumor-suppressive and oncogenic signaling pathways controls various cellular activities of cancer cells, including cell growth and apoptosis. While the activation of oncogenes fuels cancer progression and escape mechanisms, tumor suppressors regulate and counterbalance the negative effects of oncogenic signaling. …”
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