Aging, cancer, and autophagy: connections and therapeutic perspectives by Begoña Zapatería, Esperanza Arias, Esperanza Arias

“…While autophagy acts as a tumor-suppressive mechanism by preventing the accumulation of damaged organelles and proteins, cancer cells often exploit it to survive under conditions of metabolic stress and treatment resistance. …”
Get full text

Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy by Tom Verfaillie, Maria Salazar, Guillermo Velasco, Patrizia Agostinis

“…Recently, a variety of anticancer therapies have been linked to the induction of ER stress in cancer cells, suggesting that strategies devised to stimulate its prodeath function or block its prosurvival function, could be envisaged to improve their tumoricidial action. …”
Get full text

Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. This review suggests that alantolactone and isoalantolactone are potential promising anticancer candidates, but additional studies and clinical trials are required to determine their specific intracellular sites of actions and derivative targets in order to fully understand the mechanisms of therapeutic effects to further validate in cancer chemotherapy.…”
Get full text

Panoptosis – new frontier in research in head neck cancer by Shrikant B. Mali

“…Numerous studies have demonstrated that PANoptosis can successfully stop cancer cells from growing, proliferating, and developing drug resistance, changing the focus of targeted anticancer therapy.…”
Get full text

Visual Analysis of Research Hotspots in Matcha and Research Progress in Its Efficacy by WANG Yuepeng, GENG Zhanhui, ZHENG Zhiqiang, CUI Yan, YANG Liu

“…The tea polyphenols contained in matcha can inhibit the viability of cancer cells through various mechanisms, and reduce the incidence of diseases such as diabetes and cardiovascular diseases. …”
Get full text

Role of Fractalkine/CX3CL1 and Its Receptor in the Pathogenesis of Inflammatory and Malignant Diseases with Emphasis on B Cell Malignancies by Elisa Ferretti, Vito Pistoia, Anna Corcione

“…In tumors the interaction between cancer cells and cellular microenvironment creates a context that may promote tumor growth, increase tumor survival, and facilitate metastasis. …”
Get full text

The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma by Rolf Aamodt, Johan Bondi, Solveig Norheim Andersen, Arne Bakka, Geir Bukholm, Ida R. K. Bukholm

“…In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor. …”
Get full text

Hypoxia-Induced Reactive Oxygen Species: Their Role in Cancer Resistance and Emerging Therapies to Overcome It by Eleicy Nathaly Mendoza, Maria Rosa Ciriolo, Fabio Ciccarone

“…Hypoxic tumor regions experience uneven oxygen distribution with severe hypoxia in the core due to poor vascularization and high metabolic oxygen consumption. Cancer cells adapt to these conditions through metabolic shifts, predominantly relying on glycolysis, and by upregulating antioxidant defenses to mitigate reactive oxygen species (ROS)-induced oxidative damage. …”
Get full text

A Network Pharmacology Study on the Cervix Prescription for Treatment of Cervical Cancer by Yingping Zhu, Liangping Wang, Leilai Xu, Pian Ying

“…The results of our study preliminarily clarified that the cervical prescription has an inhibitory effect on cervical cancer cells.…”
Get full text

Altered Peroxisome-Proliferator Activated Receptors Expression in Human Endometrial Cancer by Paweł Knapp, Adrian Chabowski, Agnieszka Błachnio-Zabielska, Katarzyna Jarząbek, Sławomir Wołczyński

“…In opposite, PPARγ protein expression was lower in endometrial cancer cells. In each case, immunohistochemical reaction was confined to the perinuclear and/or nuclear region. …”
Get full text

DNA Vaccination: Using the Patient's Immune System to Overcome Cancer by Georg Eschenburg, Alexander Stermann, Robert Preissner, Hellmuth-Alexander Meyer, Holger N. Lode

“…Using the patient's own immune system by activation of humoral and cellular immune responses to target the cancer cells has shown first promising results in clinical trials and may allow reduced toxicity standard therapy regimen in the future. …”
Get full text

Is hyaluronan deposition in the stroma of pancreatic ductal adenocarcinoma of prognostic significance? by Florian Gebauer, Marius Kemper, Guido Sauter, Peter Prehm, Udo Schumacher

“…Antibody staining was found both within cancer cells and in the extracellular matrix and staining could not be eliminated by hyaluronidase predigestion of the tissue sections. …”
Get full text

Effect of Glycoconjugation on Cytotoxicity and Selectivity of 8-Aminoquinoline Derivatives Compared to 8-Hydroxyquinoline by Gabriela Pastuch-Gawołek, Julia Szreder

“…The resulting glycoconjugates, as well as their potential metabolites, were evaluated for their ability to inhibit the proliferation of cancer cell lines (including HCT 116 and MCF-7) and a healthy cell line (NHDF-Neo). …”
Get full text

Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments by Ashokkumar Veeramuthu

“…These carotenoids directly target the oral cancer cells, triggering their programmed death, restraining proliferation, and hindering tumor advancement. …”
Get full text

Metachronous Schnitzler’s Metastasis of Gastric Adenocarcinoma 13 Years After Curative Resection: A Case Report by Jun Kyeong Lim, Suk Bae Kim, Hyun Deok Shin

“…An immunohistochemistry study confirmed CK7 positive, CK20 negative, MUC2 negative, and CDX2 focally positive immune phenotype for cancer cells, suggesting a diagnosis of metastatic adenocarcinoma with a gastric origin rather than a prostate and rectal origin.…”
Get full text

DRG2 as a Biomarker to Enhance the Predictive Efficacy of PD-L1 Immunohistochemistry Assays by Muralidharan Mani, Seong Hee Choi, Hyuk Nam Kwon, Jeong Woo Park

“…They discovered that DRG2 is a critical regulator of PD-L1 endosomal trafficking in cancer cells, which is essential for the proper localization of PD-L1 on the cell surface. …”
Get full text

S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function by Ying Xiong, Yefim Manevich, Kenneth D. Tew, Danyelle M. Townsend

“…Our present data show in breast cancer cells that S-glutathionylation of PDI interferes with its chaperone activity and abolishes its capacity to form a complex with ERα. …”
Get full text

CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects by Lei Tang, Xin Chen, Jianquan Hou, Xuedong Wei

“…However, previous pan-cancer studies have reported inconsistencies regarding the effects of CXCL14 on tumors, particularly concerning its expression levels in tumor tissues and its influence on various phenotypes of cancer cells. This variability is believed to stem from the context-dependent nature of CXCL14, as different sources of CXCL14 and its secretion within distinct tumor microenvironments may mediate diverse biological effects. …”
Get full text

Advances in Immunotherapy for Melanoma: A Comprehensive Review by Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Adriana López-Barcenas, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Roberto Arenas Guzman

“…Cancer-specific active immunotherapy is an experimental form of treatment that stimulates the immune system to recognize antigens on the surface of cancer cells. Current experimental approaches in immunotherapy include vaccines, biochemotherapy, and the transfer of adoptive T cells and dendritic cells. …”
Get full text

Automated recognition and segmentation of lung cancer cytological images based on deep learning. by Qingyang Wang, Yazhi Luo, Ying Zhao, Shuhao Wang, Yiru Niu, Jinxi Di, Jia Guo, Guorong Lan, Lei Yang, Yu Shan Mao, Yuan Tu, Dingrong Zhong, Pei Zhang

“…Thus, the proposed method is useful for rapidly localizing lung cancer cells based on microscopic images and outputting image interpretation results.…”
Get full text