Targeting EBV Episome for Anti-Cancer Therapy: Emerging Strategies and Challenges by Febri Gunawan Sugiokto, Renfeng Li

“…In this review, we summarize current strategies targeting the viral episome in cancer cells. We also highlight emerging technologies, such as clustered regularly interspersed short palindromic repeat (CRISPR)-based gene editing or activation, which offer promising avenues for selective targeting of the EBV episome for anti-cancer therapy. …”
Get full text

Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and Cancer by Hiroto Shinomiya

“…L-plastin is expressed in hematopoietic cell lineages and in many types of cancer cells; the isoform is thus considered to be a useful biomarker for cancer.…”
Get full text

Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets by Jean-Ehrland Ricci

“…Summary: Metabolic reprogramming in both immune and cancer cells plays a crucial role in the antitumor immune response. …”
Get full text

Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation by Athip Nilkaeo, Suthinee Bhuvanath

“…Since its direct biological effect on oral cancer cells is not well defined, in this study, we employed a KB cell line to test IL-18 activity. …”
Get full text

Imaging Molecular Expression on Vascular Endothelial Cells by In Vivo Immunofluorescence Microscopy by Judith M. Runnels, Parisa Zamiri, Joel A. Spencer, Isreal Veilleux, Xunbin Wei, Alexei Bogdanov, Charles P. Lin

“…Leukocytes as well as circulating cancer cells gain entry into tissue by interacting with adhesion molecules on the endothelial cells (EC). …”
Get full text

Regulation of Immune Cell Functions by Metabolic Reprogramming by Jaehong Kim

“…Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in many different pathological conditions other than cancer. …”
Get full text

Protocol to develop A 3D tumor model for drug testing applications by Prasiddha Guragain, Sunil Singh, Hossein Tavana

“…This article presents a protocol for creating a 3D organotypic tumor model by embedding a cancer cell spheroid within a collagen matrix containing dispersed fibroblasts. …”
Get full text

Nanotechnology in photodynamic therapy by Shrikant B. Mali, Sachinkumar Dattatray Dahivelkar, Swapna Arunkumar Mahale

“…Photodynamic therapy (PDT) is a minimally invasive treatment that employs a photosensitizer to destroy cancer cells. Its efficiency is determined by the activation light features, which include the photosensitizer molecule, light wavelength, tumour location, and microenvironment. …”
Get full text

Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species by Jinglin Zou, Cong Jiang, Qiangsheng Hu, Xinlin Jia, Shuqi Wang, Shiyue Wan, Yuanqing Mao, Dapeng Zhang, Peng Zhang, Bin Dai, Yongsheng Li

“…Amplification of oxidative stress has been successfully employed for tumor therapy, but the interactions between cancer cells and the other factors of TME usually lead to inadequate tumor treatments. …”
Get full text

Telomerase inhibiting phytochemicals derived from Blumea eriantha for cancer treatment: A comprehensive computational analysis by Rahil Ummar Faruk Abbu, Shaik Mohammad Abdul Fayaz, Divyashree M S, Raghu Chandrashekhar H, Prasanna Kumar Reddy Gayam, Archana Mahadev Rao

“…Background: One potential treatment target for cancer cells is telomerase, an essential enzyme involved in the longevity of cancer cells. …”
Get full text

CXCR4 promotes tumor stemness maintenance and CDK4/6 inhibitors resistance in ER-positive breast cancer by Qiangfeng Shi, Wang Yang, Yiye Ouyang, Yujie Liu, Zijie Cai

“…Methods RNA sequencing and KEGG pathway analysis was carried out to identify the mainly dysregulated genes in CDK4/6 inhibitors-resistant breast cancer cells. The effects of CXCR4 knockdown and overexpression via siRNAs and plasmids transfection were examined by mammosphere formation, RT-qPCR, flow cytometry, MTT and colony formation assays. …”
Get full text

Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis by Yinyin Wang, Bingdong Zhang, Chunhua He, Bo Tian, Sihan Liu, Jianghua Li, Jiayu Wang, Shigao Yang, Bingtao Zhu, Xiaoguang Wang, Zhijie Chang, Chenxi Cao

“…NOK enhanced EGF-induced phosphorylation of STAT3 and STAT5 via its juxtamembrane (JM) domain in promoting the proliferation and migration of breast cancer cells. Overexpression of NOK and EGFR synergistically induced the tumorigenesis of NIH-3T3 normal cells. …”
Get full text

RETRACTED ARTICLE: A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6 by Lizhe Wang, Yu Wang, Yueyang Li, Li Zhou, Sihan Liu, Yongyi Cao, Yuzhi Li, Shenting Liu, Jiahui Du, Jin Wang, Ting Zhu

“…A temporal analysis of breast cancer cells using single-cell RNA sequencing provided insights into cellular developmental trajectories and highlighted changes in expression patterns across key genes during disease progression. …”
Get full text

Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

“…Understanding the complex and sometimes reciprocal relationships among cancer cells, CAFs, immune cells, and ECs has led to novel insights into their immense heterogeneity in functions, which can have important consequences on tumor behavior. …”
Get full text

Blue-LED assisted Photodegradation kinetics of rhodamine-6G dye, enhanced anticancer activity and cleavage of plasmids using Au-ZnO nanocomposite by Pilavadi Thangamuniyandi, Devan Umapathy, Loganathan Nagarajan, Antony Joseph Velanganni Arockiam

“…Further, the blue-LED assisted anti-cancer studies (MTT assay) using 0.015-Au-ZnO towards human lung cancer cells (A549), breast cancer cells (SKBr3) show high anti-proliferation rate and low cytotoxicity against healthy human embryonic kidney cells (HEK-293) with an IC50 value of 65, 53 and 124 μg/mL respectively. …”
Get full text

Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells by Annarita Nappi, Vittoria D’Esposito, Caterina Miro, Alessia Parascandolo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Sepehr Torabinejad, Federica Restolfer, Maddalena Raia, Melania Murolo, Emery Di Cicco, Pietro Formisano, Monica Dentice

“…Conclusions: Thus, we argue that intracellular activation of THs via D2 is a critical requirement for invasive and metastatic conversion of breast cancer cells, advising the blocking of D2 as a potential therapeutic tool for cancer therapy.…”
Get full text

Oxaliplatin-Loaded Chitosan Nanoparticles Decorated with Cetuximab Single-Chain Variable Fragment for Human Colorectal Cancer Treatment by Khadijeh Falahzadeh, Fariba Esmaeili, Leila Nematollahi, Elham Bayat, Mehdi Khoobi, Mohammadali Mazloomi, Masumeh Jalalvand, Reza Faridi Majidi, Babak Negahdari

“…This delivery system offers a promising method for delivering chemotherapy drugs to cancer cells. Moreresearch is needed on the best strategies for improving treatment efficacy by targeting cancer cells.…”
Get full text

Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts by Sara Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, A Cataldo, G Cosentino, V Angeloni, A Rossini, M G Daidone, M V Iorio

“…Abstract It is established that the interaction between microenvironment and cancer cells has a critical role in tumor development, given the dependence of neoplastic cells on stromal support. …”
Get full text

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…The immune microenvironment of HVEM KO mice bearing mouse lung cancer cell was also evaluated. Co-cultured system and phenotype assays facilitated the examination of Jurkat T cells’ effect on A549 and H1299 lung cancer cells. …”
Get full text

Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation by Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

“…In vivo experimental results showed that RosA could inhibit the growth of transplanted tumors in nude mice bearing tumors of lung cancer cells, reduce the positive expression of Ki67 in lung tumor tissue, and hinder the proliferation of lung tumor cells. …”
Get full text