Functionalized Nanomaterials In Pancreatic Cancer Theranostics And Molecular Imaging by Yoghalakshmi Nagarajan, Natarajan Chandrasekaran, Venkatachalam Deepa Parvathi

“…To increase the efficiency of existing therapies and modify target nanoparticles, several molecular markers of pancreatic cancer cells have been identified. Thus pancreatic cancer cells can be detected using appropriately functionalized nanoparticles with specific signalling molecules. …”
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RAGE and its ligands in breast cancer progression and metastasis by Madalina Coser, Bogdan Mihai Neamtu, Bogdan Mihai Neamtu, Bogdan Pop, Bogdan Pop, Calin Remus Cipaian, Calin Remus Cipaian, Maria Crisan, Maria Crisan

“…In addition, studies have shown that RAGE and its ligands influence the way breast cancer cells interact with immune cells present in the tumor microenvironment (macrophages, fibroblasts), thus regulating it to promote tumor growth and metastasis.ConclusionBreast cancers with a high expression of RAGE are associated with poor prognosis. …”
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Comparative analysis of lactaptin activity when produced in bacterial or eukaryotic expression systems by O. A. Koval, O. Y. Volkova, A. A. Gorchakov, S. V. Kulemzin, A. V. Tkachenko, A. A. Nushtaeva, E. V. Kuligina, V. A. Richter, A. V. Taranin

“…Taken together, our results provide an opportunity for developing armored immune cells as an “off-the-shelf” platform for targeted delivery of lactaptin to cancer cells.…”
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Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

“…Upon internalized by cancer cells, TLA was specifically accumulated in lysosome, and which would destroy the integrity of lysosomal membranes and inhibit protective autophagy upon exposure to light irradiation. …”
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Metformin as an adjuvant option for systemic treatment of breast cancer by D.I. Avierin, V.F. Zavizion

“…Second – the method of regulating the proliferation of tumor cells involves the PIK3 branch of the regulatory cascade of biological reactions in cancer cells. In addition, metformin reduces the development of resistance in breast cancer cells, thus allowing active chemotherapy agents to act in synergism. …”
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Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer by Takefumi Itami, Yukinori Kurokawa, Takaomi Hagi, Shinnosuke Nagano, Rennosuke Nakamoto, Yu Kamakura, Tsuyoshi Takahashi, Takuro Saito, Kazuyoshi Yamamoto, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki

“…In vitro studies demonstrated that nerve elongation of PC12 cells, a model for sympathetic neuron-like cells, was promoted by co-culture with gastric cancer cells expressing high NGF levels whereas nerve elongation was suppressed by NGF knockdown. …”
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Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents by Benjamin Victoir, Océane Pertegaz, Elfi Ducrocq, Marion Polomski, Maxime Guéguinou, William Raoul, Cécile Croix, Gildas Prié

“…Compared with 5-fluorouracil classically used in the treatment strategy for colorectal cancer patients, some of our compounds showed better activity on cancer cells. In particular, compound 1b blocked the growth of colorectal cancer cells at sub-micromolar concentrations, thus represents a promising lead compound in the fight against colorectal cancer.…”
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The effect of miR-381 on proliferation and prognosis of breast cancer by altering CCNA2 expression by Ming-Gang Cao, Yan Wang, Zhi-Min Yang, Yang Wang, Mei-Qing Wang, Shuai Zhuo, Yan Yang, Chun-Sheng Liu

“…Background MiR-381 can regulate the expression of cyclin A2 (CCNA2) to inhibit the proliferation and migration of bladder cancer cells, but whether miR-381 has the same function in breast cancer is not well know.Methods The over express or silence miR-381 expressing cell lines were constructed by lentivirus infection to reveal the biological functions of miR-381 in vitro. …”
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Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions by Marina G. Gobbo, Nishtman Dizeyi, Per-Anders Abrahamsson, Per-Anders Bertilsson, Viviane Sanches Masitéli, Eloisa Zanin Pytlowanciv, Sebastião R. Taboga, Rejane M. Góes

“…The antitumor properties of melatonin (MLT) are known for prostate cancer cells. This study investigated whether MLT affects prostate maturation and interferes with tissue injuries induced by diabetes. …”
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Biophysical Insights into Cancer Transformation and Treatment by Jiří Pokorný, Alberto Foletti, Jitka Kobilková, Anna Jandová, Jan Vrba, Jan Vrba, Martina Nedbalová, Aleš Čoček, Andrea Danani, Jack A. Tuszyński

“…Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. …”
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The Genetic Expression Difference of A2058 Cells Treated by Plasma Direct Exposure and Plasma-Treated Medium and the Appropriate Treatment Strategy by Chao-Yu Chen, Chung-Hsien Chou, Yun-Chien Cheng

“…This study investigated the effects of direct and indirect treatments of Argon-based CAP to cancer cells (A2058, A549, U2OS and BCC) and fibroblasts (NIH3T3 and L929) on cell viability. …”
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Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1 by Baocheng Xie, Peishan Wu, Hongyu Liu, XiangDi Yang, Linxuan Huang

“…Moreover, depletion of MIR4435-2HG sensitized pancreatic cancer cells to gemcitabine-induced growth inhibition and ferroptosis. …”
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The potential of Curcuma longa L. bioactive compounds as RSK inhibitors for the treatment of prostate cancer: in silico study by Olusola Olalekan Elekofehinti, Foluso Adeola Taiwo, Moses Orimoloye Akinjiyan, Ifeoluwa Rachael Adetoyi, Folasade Oluwatobiloba Ayodeji, Adedotun Olayemi Oluwatuyi, Oluwapelumi Nifesimi Akintoye, Idayat Oyinkansola Kehinde, Bolanle Esther Adedapo, Opeyemi Iwaloye

“…The p90 ribosomal s6 kinase (RSK) has attracted increased attention due to its overexpression in cancer cells, especially prostate cancer cells. Significant progress has been made recently to develop RSK inhibitors to treat prostate cancer, but these efforts have shown limited success. …”
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Potential Use of C60/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer by Abdulmalik Altaf, Hibah Aldawsari, Zainy M. Banjar, Daisuke Iohara, Makoto Anraku, Kaneto Uekama, Fumitoshi Hirayama

“…C60/HP-β-CyD reduced the viability of cancer cells (HeLa cells and A549 cells) in response to irradiation by visible light in a dose-dependent manner. …”
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Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroi... by Angela Russo, Junlone Moy, Manead Khin, Timothy R. Dorsey, Alfredo Lopez Carrero, Joanna E. Burdette

“…In addition, CRISPR-CAS9 was used to delete LOXL2 in OVCAR8 ovarian cancer cells. We monitored the changes in tumorigenic properties, such as migration, invasion, and growth of three-dimensional (3D) spheroids, to assess whether the loss of LOXL2 resulted in any changes. …”
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Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1 by Naeme Javid, Shahriyar Abdoli, Majid Shahbazi, Majid Shahbazi

“…We sought to investigate the functional genomic response and altered metabolic pathways of human cancer cells to oHSV-1 infection and to elucidate the influence of these responses on the relationship between the virus and the cancer cells.MethodsTwo datasets containing gene expression profiles of tumor cells infected with oHSV-1 (G207) and non-infected cells from the Gene Expression Omnibus (GEO) database were processed and normalized using the R software. …”
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Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment by Jeffrey Koury, Li Zhong, Jijun Hao

“…Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. …”
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Computational modeling approaches to studying the dynamics of oncolytic viruses by Dominik Wodarz

“…Oncolytic viruses specifically infect cancer cells, replicate in them, killthem, and spread to further tumor cells. …”
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THE GENUS AS, A POTENTIAL SOURCE OF ANTICANCER AGENT: AN UPDATED REVIEW

“…Defects in regulating apoptotic pathways enable cancer cells to become chemoresistant,  highlighting the need to develop new anti-apoptotic drugs to combat the disease. …”
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Optimal Control of Anti-Angiogenesis and Radiation Treatments for Cancerous Tumor: Hybrid Indirect Solver by Iman Alimirzaei, Alaeddin Malek

“…This paper proposes a real-life volume reduction for cancer cells using optimal doses of radiation and an anti-angiogenic drug. …”
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