Exploring the protective role of caffeine against Taraxacum-Induced ribotoxic stress mediated through autophagy and mitochondrial depolarization by Chien-Jung Lin, Shu-Ting Liu, Zih-Syuan Wu, Shih-Ming Huang, Teng-Wei Chen

“…T. formosanum induced the N-terminal clipping of histone H3, which was observed not only in human HeLa cervical cancer cells but also in human Huh6 and HepG2 liver cancer cells. …”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…T-cell engaging (TCE) bispecific antibodies are potent drugs that trigger the immune system to eliminate cancer cells, but administration can be accompanied by toxic side effects that limit dosing. …”
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Adipokines in Breast Cancer: Decoding Genetic and Proteomic Mechanisms Underlying Migration, Invasion, and Proliferation by Ließem A, Leimer U, Germann GK, Köllensperger E

“…A concentration-dependent increase in migration and invasion was generally observed, with no significant reductions in any approaches.Conclusion: We could show a robust promoting effect of several adipokines on different breast cancer cells in vitro. Understanding the interaction between adipose tissue and breast cancer cells opens potential avenues for innovative breast cancer prevention and therapy strategies. …”
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Tumor-associated macrophage-derived exosome miR-194 confers cisplatin resistance in GC cells by Yi Zhou, Yang-cheng Sun, Qiong-yan Zhang, Jing Wang, Xian-ya Zhu, Xiang-yu Su

“…Results Results indicate that M2 macrophages enhance cisplatin resistance in gastric cancer cells mainly through miR-194, as demonstrated by CCK-8 and apoptosis assays. …”
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Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells by Zorka Milićević, Vladan Bajić, Lada Živković, Jelena Kasapović, Uroš Andjelković, Biljana Spremo-Potparević

“…One of the most intriguing findings is that mutant p53 appears as discrete dot-shaped regions within the nucleus of breast cancer cells. In many malignant cells, the nucleolar sequestration of p53 is evident. …”
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Rhus Verniciflua Stokes Inhibits PD-1 Expression and Induces Anticancer Effects by Enhancing T Cell Function by Seoyoung Kim PhD, Young-Kwan Lee PhD, Wang-Jun Lee MD, PhD, Hyoun Jong Moon MD, PhD, Sanghun Lee KMD, PhD

“…The anticancer activity of these T cells was evaluated by introducing red fluorescent protein (RFP) into HLA-A02:01 type-matched breast cancer cell lines (MCF7 and MDA-MB-231) and analyzing the results using flow cytometry. …”
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Synthesis, Structural Characterization, and Preclinical Efficacy of a Novel Paclitaxel-Loaded Alginate Nanoparticle for Breast Cancer Treatment by Ahmed A. Markeb, Nagwa A. El-Maali, Douaa M. Sayed, Amany Osama, Mohamed A. Y. Abdel-Malek, Amen H. Zaki, Mostafa E. A. Elwanis, James J. Driscoll

“…The antitumor activity of a novel alginate (ALG) polymer-based particle that contained paclitaxel (PTX) was evaluated using human primary breast cancer cells. Materials and Methods. PTX was combined with ALG in a nanoparticle as a drug delivery system designed to improve breast cancer tumor cell killing. …”
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Andrographolide-encapsulated nanoliposomes with gum Arabic surface modification inhibits cervical cancer growth: In vitro and in silico approaches by Rahmalillah Khairiah, Dwi Hudiyanti, Parsaoran Siahaan, Fadzilah Adibah Abdul Majid, Enny Fachriyah, Nor Hafizah Zakaria

“…All things considered, this study highlights the possibility of employing AND encapsulated in nanoliposomes to successfully regulate the proliferation of cervical cancer cells.…”
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Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair by Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

“…We further showed that FHIT inactivation leads to the activation of DNA damage repair pathways, including the HRR and NHEJ pathways, in lung cancer cells. Conversely, FHIT-deficient cells are highly dependent on HRR for survival under DNA damage stress. …”
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Integrated analysis of single-cell and bulk-RNA sequencing for the cellular senescence in prognosis of lung adenocarcinoma by Fengqiang Yu, Liangyu Zhang, Xun Zhang, Jianshen Zeng, Fancai Lai

“…Telomerase, which maintains telomere length and chromosomal integrity, enables cancer cells to avoid replicative senescence. When telomerase is inhibited, cancer cells’ senescence began, preventing them from growing indefinitely. …”
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GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis by Dušica Ristić, Thomas Bärnthaler, Eva Gruden, Melanie Kienzl, Laura Danner, Karolina Herceg, Arailym Sarsembayeva, Julia Kargl, Rudolf Schicho

“…The role of GPR55 in cancer cells has been widely described, but its role in the immune TME is not well understood. …”
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Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA by Xinmin Zhao, Xianghua Wu, Huijie Wang, Songtao Lai, Jialei Wang

“…The SELEX technology was used to identify aptamers that specifically recognize DDP‐resistant lung cancer cells and couple them with nano‐zinc (zinc hydroxide, Zn(OH)2) carriers. …”
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Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro by Rudolfová Petra, Hanušová Veronika, Skálová Lenka, Bártíková Hana, Matoušková Petra, Boušová Iva

“…All of the studied catechins (1-25 μmol L-1) had no effect on the proliferation of intestinal cancer cells and did not affect the antiproliferative effect of DOX (1-8 μmol L-1) in these cells. …”
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Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery by Jessica L. Woodman, Min Sung Suh, Jianxing Zhang, Yuvabharath Kondaveeti, Diane J. Burgess, Bruce A. White, Glenn D. Prestwich, Liisa T. Kuhn

“…nCaPCMHA-AF488 was taken up by CD44+/CD24− BT-474EMT breast cancer cells within 18 hours. nCaPCMHACDDP was as cytotoxic as free CDDP against the BT-474EMT cells. …”
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Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells by Shinan Li, Shinan Li, Dhiraj Kumar Sah, Archana Arjunan, Mohamed Yazeer Ameer, Bora Lee, Young-Do Jung

“…IL-8, a proinflammatory cytokine, is associated with cancer cell proliferation and angiogenesis. Here, we found that Triptolide has an inhibitory effect on IL-1β-induced IL-8 expression in human gastric cancer cells, via the suppression of reactive oxygen species (ROS) production, AP-1, and NF-κB activation, which in turn affects human endothelial cell angiogenetic activity in tumor microenvironments. …”
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Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance by Xia-Lu Hong, Chen-Kai Huang, Hui Qian, Chen-Hong Ding, Fang Liu, Huan-Yu Hong, Shu-Qing Liu, Si-Han Wu, Xin Zhang, Wei-Fen Xie

“…YAP activates the transcription of SLC43A2, the methionine transporter, to increase methionine uptake in cancer cells. Knockdown of SLC43A2 decreases the level of YAP R124me2a. …”
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An Efficient Dual-Sampling Approach for Chest CT Diagnosis by Alshamrani K, Alshamrani HA

“…Khalaf Alshamrani,1,2 Hassan A Alshamrani1 1Radiology Sciences Department, College of Medical Sciences, Najran University, Najran, Saudi Arabia; 2School of Medicine and Population Health, University of Sheffield, Sheffield, UKCorrespondence: Khalaf Alshamrani, Email Kaalshamrani@nu.edu.sa, k.alshamrani@sheffield.ac.ukBackground: This paper aimed to enhance the diagnostic process of lung abnormalities in computed tomography (CT) images, particularly in distinguishing cancer cells from normal chest tissue. The rapid and uneven growth of cancer cells, presenting with variable symptoms, necessitates an advanced approach for accurate identification.Objective: To develop a dual-sampling network targeting lung infection regions to address the diagnostic challenge. …”
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Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer by Chenlin Liu, Dong Fan, Jiahui Sun, Guodong Li, Ruoxin Du, Xiaoshuang Zuo, Kuo Zhang, Wangqian Zhang, Shuning Wang, Xiaojv Li, Mingrui Du, Donghui Wang, Qiang Hao, Yingqi Zhang, Meng Li, Cun Zhang, Yuan Gao

“…Mechanistically, METTL14 can induce an increase in E2F1 expression in breast cancer cells via an m6A IGF2BP2-dependent mechanism and thus promote CDK4/6i resistance. …”
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PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis by JinJing Pan, Ping Wang, Linghong Xiong, Wenqing Yang, Jie Li, Kai Yang, Bingyan Li

“…In this study, our findings not only demonstrated the effective encapsulation of 1,25(OH)2D3 in PLGA (PLGA-1,25(OH)2D3, PD) but also indicated that the PD has a more potent inhibitory effect on the proliferation and migration of breast cancer cells compared with 1,25(OH)2D3 alone. Consistently, PD exhibits superior efficacy in suppressing subcutaneous neoplasia and lung metastasis of breast cancer cells compared to 1,25(OH)2D3. …”
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Integrin Trafficking and Tumor Progression by Sejeong Shin, Laura Wolgamott, Sang-Oh Yoon

“…Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. …”
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