A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…The experimental results revealed that AS1411-HSA-LDP effectively binds to esophageal cancer cells and could be efficiently internalized by esophageal cancer cells. …”
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Expression and Clinical Significance of DAP3 in Breast Cancer and Effect of Bruceine D on Expression of DAP3:Analysis Based on Data-mining from Bioinformatics by Wenlong WANG, Qingzhi KONG, Hongda LU, Qingdong XIANG, Dianlei LIU

“…In addition, CCLE database analysis indicated that DAP3 was also highly expressed in breast cancer cell lines and its mRNA expression ranked ahead in all kinds of cancer cell lines. …”
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The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels by Xiong Weichen, Fan Huizhen, Zeng Qingye, Deng Zhenhui, Li Guanhui, Lu Wancheng, Zhang Bei, Lai Shian, Chen Xin, Xu Xueqing

“…Voltage-gated K+ (Kv) channels play a role in the cellular processes of various cancer cells, including lung cancer cells. We previously identified and reported a salivary protein from the Xenopsylla cheopis, FS48, which exhibited inhibitory activity against Kv1.1-1.3 channels when assayed in HEK 293T cells. …”
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Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis by Shang Wu, Xindi Ma, Xiangmei Zhang, Kaiye Du, Chao Shi, Ahmed Ali Almaamari, Boye Han, Suwen Su, Yunjiang Liu

“…We knocked down NDUFAF6 in breast cancer cells using small interfering RNA and investigated its effects on cell proliferation and migration ability. …”
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Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway by Yuhua Zhou, Jing Lv, Shengkai Jin, Chaowei Fu, Bo Liu, Yang Shen, Menglu Li, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…TMAO promotes the proliferation and migration of prostate cancer cells by activating the p38 pathway and increasing HMOX1 expression. …”
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Studying breast cancer lung metastasis using a multi-compartment microfluidic device with a mimetic tumor-stroma interaction model by Bahareh Zarin, Laleh Rafiee, Sorosh Abdollahi, Maryam Vatani, Mohsen Hassani, Amir Sanati-Nezhad, Shaghayegh Haghjooy Javanmard

“…Results: The cytotoxic effect of β4 integrin blockade on cancer cells gradually increased after 48 and 72 h of co-culture. …”
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Nongenetic evolution of the tumor: from challenges to new therapeutic opportunities by Elisa Oricchio

“…The ability of cancer cells to change and adapt poses a critical challenge to identifying curative solutions. …”
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Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone by Tomohiko Yagi, Shunsuke Kagawa, Shohei Nogi, Atsuki Taniguchi, Masashi Yoshimoto, Kanto Suemori, Yasuo Nagai, Shuto Fujita, Shinji Kuroda, Satoru Kikuchi, Yoshihiko Kakiuchi, Fuminori Teraishi, Kosei Takagi, Toshiaki Ohara, Hiroshi Tazawa, Toshiyoshi Fujiwara

“…The interactions between cancer cells, CAFs, and neutrophils can be disrupted by PFD, highlighting a potential therapeutic approach.…”
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The discovery and characterization of K‐563, a novel inhibitor of the Keap1/Nrf2 pathway produced by Streptomyces sp by Ran Hori, Kozo Yamaguchi, Hidetaka Sato, Miwa Watanabe, Kyoko Tsutsumi, Susumu Iwamoto, Masayuki Abe, Hideyuki Onodera, Satoshi Nakamura, Ryuichiro Nakai

“…K‐563 also inhibited the expression of downstream target genes in other Keap1‐ or Nrf2‐mutated cancer cells. Furthermore, K‐563 exerted anti‐proliferative activities in these mutated cancer cells. …”
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In Vitro and In Vivo Evaluation of Alexa Fluor 680-Bombesin[7–14]NH Peptide Conjugate, a High-Affinity Fluorescent Probe with High Selectivity for the Gastrin-Releasing Peptide Rec... by Lixin Ma, Ping Yu, Bhadrasetty Veerendra, Tammy L. Rold, Lauren Retzloff, Adam Prasanphanich, Gary Sieckman, Timothy J. Hoffman, Wynn A. Volkert, Charles J. Smith

“…Gastrin-releasing peptide (GRP) receptors are overexpressed on several types of human cancer cells, including breast, prostate, small cell lung, and pancreatic cancers. …”
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Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1 by Yanhong Zhang, Changli Yue, Anna M. Krichevsky, Igor Garkavtsev

“…Moreover, treatment of breast tumor‐bearing mice with C108 resulted in a significant survival benefit and long‐term cures. Cancer cells treated with C108 or cancer cells with genetically repressed G3BP2 had decreased PD‐L1 expression due to enhanced mRNA degradation. …”
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Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases by Ikechukwu P. Ejidike, Peter A. Ajibade

“…In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. …”
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Identification of KRT16 and ANXA10 as cell cycle regulation genes for lung adenocarcinoma based on self-transcriptome sequencing of surgical samples and TCGA public data mining by Wen-jian Liu, Jia-pan Shen, Ren-quan Zhang, Xiao-yun Fan

“…The knockdown of KRT16 and ANXA10 inhibited the proliferation of lung cancer cells, and the cell cycle was blocked in the G1 phase. …”
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Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways by Xiao Chen, Luping Lin, Qiaoling Wu, Sang Li, Huihui Wang, Yang Sun

“…We found that TNF-α significantly stimulated cervical cancer cells to secrete VEGFC. Additionally, the CM collected from the TNF-α-treated cervical cancer cells notably promoted the proliferation, migration, and angiogenesis of HLECs; however, these changes were reversed by MAZ51, a VEGFR3 inhibitor. …”
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Photocatalytic Inactivation Effect of Gold-Doped TiO2 (Au/TiO2) Nanocomposites on Human Colon Carcinoma LoVo Cells by Juan Xu, Yi Sun, Yaomin Zhao, Junjie Huang, Chunmei Chen, Zhiyu Jiang

“…But for 50 μg/mL TiO2 nanoparticles, only 40% cancer cells were killed under the same condition.…”
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Hypermethylation at 45S rDNA promoter in cancers. by Trang Thi Quynh Tran, Trang Hien Do, Tung The Pham, Phương Thi Thu Luu, Oanh Minh Pham, Uyen Quynh Nguyen, Linh Dieu Vuong, Quang Ngoc Nguyen, Tuan Van Mai, Son Van Ho, Than Thi Nguyen, Lan Thi Thuong Vo

“…Our results are in line with the hypothesis that an increase in rDNA methylation is a natural pathway protecting rDNA repeats that are extremely sensitive to DNA damage in cancer cells.…”
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Antioxidant, antimicrobial and cytotoxic potential of condensed tannins from Leucaena leucocephala hybrid-Rendang by Mazni Abu Zarin, Ho Yin Wan, Azizul Isha, Nurdin Armania

“…Furthermore, among other selected cancer cells, CTs also demonstrated cytotoxic activity toward human breast cancer cells (MCF-7) (IC50 = 38.33 ± 2.08 μg/mL). …”
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The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy by Qinglong Ma, Wenyang Zhang, Kongming Wu, Lei Shi

“…Given that cancer cells rely on these metabolic changes to sustain cell growth and survival, targeting these processes may represent a promising therapeutic strategy for KRAS-driven cancers.…”
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Induction of SUSD2 by STAT3 Activation Is Associated with Tumor Recurrence in HER2-Positive Breast Cancer by Yisun Jeong, Hyungjoo Kim, Daeun You, Soo Youn Cho, Sun Young Yoon, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee, Sangmin Kim

“…Endogenous SUSD2 expression was observed in HER2+ breast cancer cells but not in estrogen receptor-positive or triple-negative breast cancer cells. …”
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Modeling Cancer in HIV-1 Infected Individuals: Equilibria, Cycles and Chaotic Behavior by Jie Lou, Tommaso Ruggeri, Claudio Tebaldi

“…In this paper, an HIV-1 dynamicalmodel incorporating the AIDS-related cancer cells was studied. The model consists of three components, cancer cells, healthy CD4+ T lymphocytesand infected CD4+ T lymphocytes, and can have six steady states. …”
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