Expression and clinical significance of disulfidptosis-related LncRNA in gastric cancer by CHU Yudan, SUN Haidong, CUI Ran, ZHENG Hong

“…LncRNA-SNHG4 promoted the proliferation and migration of gastric cancer cells. LncRNA-SNHG4 promoted the activation of Wnt signaling pathway in gastric cancer cells. …”
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Exploring Anti-Breast Cancer Effects of Live Pediococcus acidilactici and Its Cell-Free Supernatant Isolated from Human Breast Milk by Naa N. Adumuah, Jude T. Quarshie, Harry Danwonno, Anastasia R. Aikins, Elmer N. Ametefe

“…Exposure of MDA-MB 231 breast cancer cells to live P. acidilactici and its cell-free supernatant (CFS) for 24 h resulted in a reduction in cancer cell viability. …”
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Active Roles of Tumor Stroma in Breast Cancer Metastasis by Zahraa I. Khamis, Ziad J. Sahab, Qing-Xiang Amy Sang

“…Tumors are heterogenous cellular entities composed of cancer cells and cells of the microenvironment in which they reside. …”
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LncRNAs: New Players in Apoptosis Control by Marianna Nicoletta Rossi, Fabrizio Antonangeli

“…Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli. …”
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Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells by Amanda C. Stacer, Hanxiao Wang, Joseph Fenner, Joseph S. Dosch, Anna Salomonnson, Kathryn E. Luker, Gary D. Luker, Alnawaz Rehemtulla, Brian D. Ross

“…Breast cancer cells with low proteasome activity had greater local tumor formation and metastasis in immunocompromised and immunocompetent mice. …”
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Bilayer 3D co‐culture platform inducing the differentiation of normal fibroblasts into cancer‐associated fibroblast like cells: New in vitro source to obtain cancer‐associated fibr... by Yeon Ju Kim, Hyeon Song Lee, Dohyun Kim, Hwa Kyung Byun, Woong Sub Koom, Won‐Gun Koh

“…Moreover, co‐culture with CAF induced radio‐ and chemoresistance in pancreatic cancer cells (PANC‐1). Survival rate of cancer cells post‐irradiation and gemcitabine resistance increased significantly in the co‐culture setting, highlighting the role of CAFs in promoting cancer cell survival and therapeutic resistance. …”
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Multifaceted Characterization and Therapeutic Evaluation of Co-precipitated Cobalt Ferrite Nanoparticles for Magnetic Hyperthermia Cancer Therapy by R. Jafrin Reena, N. Arunai Nambi Raj

“…The in vitro studies also disclose the efficacy of the drug over cancer cells.…”
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Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis by Toshihisa Ishikawa, Hiroshi Nakagawa, Yuichiro Hagiya, Naosuke Nonoguchi, Shin-ichi Miyatake, Toshihiko Kuroiwa

“…Accumulating evidence indicates that ATP-binding cassette (ABC) transporter ABCG2 plays a key role in regulating the cellular accumulation of porphyrin derivatives in cancer cells and thereby affects the efficacy of photodynamic therapy and photodynamic diagnosis. …”
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Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy by Moisés Blanco Calvo, Angélica Figueroa, Enrique Grande Pulido, Rosario García Campelo, Luís Antón Aparicio

“…In fact, sugar transporters are deregulated in cancer cells so they incorporate higher amounts of sugar than normal cells. …”
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Virotherapy in Head and Neck Cancer by Zhan Wang

“…Virotherapy involves the use of genetically modified viruses as therapeutic agents to selectively target and destroy cancer cells while sparing healthy tissues. The primary focus of virotherapy is to exploit the inherent properties of viruses to infect and replicate within cancer cells, triggering immune responses and promoting anti-tumor effects. …”
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Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin by LIU Fengying, HUANG Yide, LIN Jia, CHEN Xuequn, WANG Qingshui, LIN Yao

“…The functions were verified in gastric cancer, colorectal cancer and other gastrointestinal tumors, and the activity and function of recombinant Irisin-Irisin and monomeric Irisin on tumor cells were compared.Results(1) Expression and purification of recombinant Irisin-Irisin: compared with the non-induced samples, the recombinant Irisin-Irisin was significantly expressed after IPTG induction; high purity recombinant Irisin-Irisin with a molecular weight of about 27 kDa was obtained by Ni Sepharose excel. (2) Detection of recombinant Irisin-Irisin activity: compared with the blank control group, both the recombinant Irisin-Irisin group and the Irisin group could up-regulate the expression of UCP-1 in C2C12 cells (<italic>P</italic>&lt;0.05); compared with the Irisin group, the recombinant Irisin-Irisin group had a more significant effect and stronger activity in inducing UCP-1 (<italic>P</italic>&lt;0.05). (3) Recombinant Irisin-Irisin on tumor function: compared with the blank control group, both the 100 ng/mL and 200 ng/mL Irisin-Irisin groups could inhibit the migration of gastric cancer cells and colorectal cancer cells(<italic>P</italic>&lt;0.05), but had no effect on their proliferation and clone formation; compared with the Irisin group, the recombinant Irisin-Irisin group had a more significant effect on cell migration inhibition (<italic>P</italic>&lt;0.05).ConclusionThe recombinant Irisin-Irisin expressed by <italic>Escherichia coli</italic> has activity, and the activity is higher than that of the monomeric Irisin; recombinant Irisin-Irisin has an effect on the migration of gastric cancer cells and colorectal cancer cells, and the effect was better than that of the monomeric Irisin.…”
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Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation by Abeer Ezzat, Mohga Shafiek, Shimaa Shawki, Shaimaa Abdel-Ghany, Mahmoud Nazih, Hussein Sabit

“…Abstract This study was designed to assess the effect of brentuximab vedotin on several breast cancer cell lines in terms of promoting apoptosis and managing cancer progression. …”
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The role of Box A of HMGB1 in producing γH2AX associated DNA breaks in lung cancer by Sirapat Settayanon, Pithi Chanvorachote, Apiwat Mutirangura

“…Since the formation of HMGB1-produced DNA gaps in cancers may differ from normal cells, the outcome of introducing Box A into cancer cells may be different. We demonstrated that in lung cancer cells, γH2AX foci and histone modification associating DSBs were produced by Box A. …”
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Stress Proteins and Pancreatic Cancer Metastasis by Carla E. Cano, Juan L. Iovanna

“…This review summarizes the multiple functions accomplished by one major factor of pancreatic cancer cell stress response, the stress protein p8.…”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Abstract Background Cancer cells are avid extracellular vesicle (EV) producers. …”
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Histone Deacetylation Regulated by KDM1A to Suppress DACT1 in Proliferation and Migration of Cervical Cancer by Lingjuan Zeng, Chunyan Chen, Chanjiao Yao

“…Increased expression of KDM1A and decreased expression of DACT1 in cervical cancer cells were noticed in a previous study. This study is aimed at exploring the mechanism behind the KDM1A regulation on DACT1 in cervical cancer cells. …”
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MHC Class 1 and PDL-1 Status of Primary Tumor and Lymph Node Metastatic Tumor Tissue in Gastric Cancers by Ibrahim Halil Erdogdu

“…MHC-1 downregulation is most frequently observed in the tumor escape mechanism of cancer cells from the immune system. MHC-1 downregulation with increased PDL-1 expression of cancer cells has an important role in immune escape. …”
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Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants by Yanru Long, Houhui Shi, Jiatian Ye, Xiaorong Qi

“…On the one hand, the increased metabolism of ovarian cancer cells can lead to the increased production of ROS, and on the other hand, the impaired antioxidant defence system of ovarian cancer cells is not able to effectively scavenge the excessive ROS. …”
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Oncolytic Virotherapy for Hematological Malignancies by Swarna Bais, Eric Bartee, Masmudur M. Rahman, Grant McFadden, Christopher R. Cogle

“…However, in the setting of autologous HCT, relapse due to contamination of the autograft with cancer cells remains a major challenge. Ex vivo manipulations of the autograft to purge cancer cells using chemotherapies and toxins have been attempted. …”
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Biotechnology breakthroughs: Revolutionizing oral cancer treatment by Safin Hussein, Karzan Qurbani, Haider Hamzah, Seenaa Ali, Sirwan Khalid Ahmed

“…Targeted therapies, like cetuximab, disrupt specific pathways in cancer cells, inhibiting their proliferation while minimizing damage to healthy cells. …”
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