The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells by Katarína Smolková, Petr Ježek

“…Reductive carboxylation of 2-oxoglutarate by IDH2 (in the reverse Krebs cycle direction), which consumes NADPH, may follow glutaminolysis of glutamine to 2-oxoglutarate in cancer cells. When the reverse aconitase reaction and citrate efflux are added, this overall “anoxic” glutaminolysis mode may help highly malignant tumors survive aglycemia during hypoxia. …”
Get full text

Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells by Germán Alvarado Tenorio, Roberto Espinosa Neira, Carlos Alberto Ávila Orta, Gabriela Yolotzín Romero Zúñiga, Hortensia Ortega Ortiz

Get full text

Myotubularin-Related Phosphatase 3 Promotes Growth of Colorectal Cancer Cells by Bo’an Zheng, Xiaojun Yu, Rui Chai

“…In the present study, we aimed to investigate the role of myotubularin-related phosphatase 3 (MTMR3) in CRC cell growth via lentivirus-mediated small interfering RNA (siRNA) transduction in human colon cancer cell lines HCT116 and SW1116. The effect of MTMR3 knockdown on cell growth was evaluated by MTT, colony formation, and flow cytometry assays. …”
Get full text

Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis by Jiasheng Xu, Kaili Liao, Weimin Zhou

“…However, a highly dynamic equilibrium was found between cancer stem cells and cancer cells, and this indicates that cancer stem cells are no more special target and blocking the transformation of cancer stem cells and cancer cells seem to be a more significant therapy strategy. …”
Get full text

Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins by Gerd Bendas, Lubor Borsig

“…Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. …”
Get full text

Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity by Seyed Jalal Hosseinimehr, Seyed Amir Hossein Hosseini

“…In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by 131I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with 131I and/or resveratrol at different concentrations for 48 h. …”
Get full text

Characterization of Chromatin Structure-associated Histone Modifications in Breast Cancer Cells by Chang Pyo Hong, Moon Kyung Choe, Tae-Young Roh

“…Our results might provide an insight into epigenetic regulatory mechanisms explaining the association of histone modifications with open chromatin structure in breast cancer cells.…”
Get full text

Transcriptional Regulation of Fucosyltransferase 1 Gene Expression in Colon Cancer Cells by Fumiko Taniuchi, Koji Higai, Tomomi Tanaka, Yutaro Azuma, Kojiro Matsumoto

“…In this study, we clarified the transcriptional regulation of FUT1 in the DLD-1 colon cancer cell line, which has high expression of Lewis B and Lewis Y antigens, expresses the FUT1 gene, and shows α1,2-fucosyltransferase (FUT) activity. 5′-rapid amplification of cDNA ends revealed a FUT1 transcriptional start site −10 nucleotides upstream of the site registered at NM_000148 in the DataBase of Human Transcription Start Sites (DBTSS). …”
Get full text

The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB) by Vladimir F. Niculescu, Eugenia R. Niculescu

“… Evolutionary cancer cell biology reveals that the majority of cancer hallmarks trace their origins back to the premetazoic era. …”
Get full text

Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…In this study, we demonstrated that curcumin reduces colon cancer cell survival and that a decrease in lysine methylation was involved in such an effect. …”
Get full text

Impact of R-loops on oncogene-induced replication stress in cancer cells by Heuzé, Jonathan, Lin, Yea-Lih, Lengronne, Armelle, Poli, Jérôme, Pasero, Philippe

“…In this review, we discuss how these different cotranscriptional processes disrupt the progression of replication forks and how they contribute to genetic instability in cancer cells.…”
Get full text

Chromosomal Aneuploidy Affects the Global Proteome Equilibrium of Colorectal Cancer Cells by Timo Gemoll, Jens K. Habermann, Susanne Becker, Silke Szymczak, Madhvi B. Upender, Hans-Peter Bruch, Ulf Hellman, Thomas Ried, Gert Auer, Hans Jörnvall, Uwe J. Roblick

Get full text

Comparison of Cantharidin Toxicity in Breast Cancer Cells to Two Common Chemotherapeutics by Katie M. Kern, Jennifer R. Schroeder

“…In a search for this more efficient method for killing cancerous cells, we have begun studying cantharidin, a toxin used in traditional Chinese medicine, as a potential chemotherapeutic. …”
Get full text

Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment by Arghavan Fatahi, Neda Soleimani, Parviz Afrough

“…In this experimental study, we used a U87 cancer cell line (glioblastoma). The interaction between cancer cells and different concentrations of kefir drink and supernatants at 24 and 48 hours was considered. …”
Get full text

MFAP5 inhibits the malignant progression of endometrial cancer cells in vitro by Liang Guanying, Qi Zijuan, Du Chun

Get full text

Combination Effects of Docetaxel and Doxorubicin in Hormone-Refractory Prostate Cancer Cells by Eleftheria Tsakalozou, Allison M. Eckman, Younsoo Bae

“…Combination effects of docetaxel (DOC) and doxorubicin (DOX) were investigated in prostate cancer cells (PC3 and DU145). Combination indices (CIs) were determined using the unified theory in various concentrations and mixing ratios (synergy: CI<0.9, additivity: 0.9<CI<1.1, and antagonism: CI>1.1). …”
Get full text

Editorial: Prostate cancer research: tools, cancer cell types, molecular targets by Hung-Ming Lam, Alvin Y. Liu

Get full text

FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells by Wenping Lian, Zhongquan Wang, Yajie Ma, Yalin Tong, Xinyu Zhang, Huifang Jin, Shuai Zhao, Ruijing Yu, Shaotan Ju, Xinyun Zhang, Xiaona Guo, Tao Huang, Xianfei Ding, Mengle Peng

Get full text

Selection of geometrical features of nuclei оn fluorescent images of cancer cells by Ya. U. Lisitsa, M. M. Yatskou, V. V. Skakun, P. D. Pavel D. Kryvasheyeu, V. V. Apanasovich

“…The methods of geometric informative features selection of nuclei on fluorescent images of cancer cells are considered. During the survey, a review of existing geometric features was carried out, including both the signs of rotation resisted shape and displacement of the image, as well as signs of location in space. …”
Get full text

Determination of Appropriate Thresholding Method in Segmentation Stage in Detecting Breast Cancer Cells by Adem Polat, Cihat Ediz Akbaba

Subjects: Get full text