CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer by Dorian V. Ziegler, Kanishka Parashar, Lucia Leal-Esteban, Jaime López-Alcalá, Wilson Castro, Nadège Zanou, Laia Martinez-Carreres, Katharina Huber, Xavier Pascal Berney, María M. Malagón, Catherine Roger, Marie-Agnès Berger, Yves Gouriou, Giulia Paone, Hector Gallart-Ayala, George Sflomos, Carlos Ronchi, Julijana Ivanisevic, Cathrin Brisken, Jennifer Rieusset, Melita Irving, Lluis Fajas

“…Mechanistically, CDK4 enhances mitochondria-endoplasmic reticulum contact (MERCs) formation, promoting mitochondrial fission and ER-mitochondrial calcium signaling, which are crucial for TNBC metabolic flexibility. …”
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Transcriptomic analysis of melatonin on the mechanism of embryonic gonadal development in female Jilin white geese by Jin Yu, Ichraf Mabrouk, Qiuyuan Liu, Yuxuan Zhou, Yupu Song, Jingyun Ma, Fengshuo Liu, Xiangman Hu, Zhiyi Yang, Yuxia Zeng, Jingtao Hu, Yongfeng Sun

“…These DEGs were enriched in Gene Ontology (GO) terms related to the microtubule cytoskeleton, cytoskeleton, cell adhesion, and biological adhesion and the KEGG enrichment analysis suggested that the DEGs were mainly enriched in “MAPK signaling pathway”, “Wnt signaling pathway”, “Calcium signaling pathway”, “Focal adhesion”, “Neuroactive ligand-receptor interaction”, “Melanogenesis”, “mTOR signaling pathway”, “ECM-receptor interaction”, and “TGF-beta signaling pathway” in the two comparison groups. …”
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Simultaneous recording of neuronal discharge and calcium activity reveals claustrum-cortex neurosynchrony under anesthesia by Penghui Fan, Rujin Zhang, Guihua Xiao, Yilin Song, Chaowei Zhuang, Lekang Yuan, Fan Mo, Botao Lu, Zhaojie Xu, Yiding Wang, Jinping Luo, Mixia Wang, Weidong Mi, Jiangbei Cao, Qionghai Dai, Xinxia Cai

“…This work investigated the synchronous changes of neural information in CLA and cortex of mice during the whole process from wakefulness to anesthesia and then to wakefulness, and summarized the characteristics of the CLA electrophysiology and cortical calcium signaling under different inhalation anesthesia concentrations. …”
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Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ by Yong-Jik Lee, Hyun Soo Kim, Hong Seog Seo, Jin Oh Na, You-Na Jang, Yoon-Mi Han, Hyun-Min Kim

“…Pharmacological activation of α1-adrenergic receptors in C2C12 skeletal muscle cells promoted mitochondrial oxidative phosphorylation and ATP production by increasing the expression of catabolic molecules, including PPARδ, AMPK, and PGC-1α, through cytosolic calcium signaling and increased GLUT4 expression, as seen in exercise. …”
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Effects of cage size on the natural behavior, serum parameters, production performance and hypothalamic mRNA expression profiles of laying hens by Yi Wan, Ruiyu Ma, Renrong Qi, Dawei Jiang, Helong Guan, Wei Liu, Junying Li, Yan Li, Kai Zhan

“…A majority of these DEGs were involved primarily in neuroactive ligand‒receptor interactions, focal adhesion and calcium signaling pathways, which are associated with the regulation of behavioral patterns, the stress response and follicular development. …”
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Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells by Xiaoming Kang, Xiaoming Kang, Lu Ma, Lu Ma, Lu Ma, Jie Wen, Jie Wen, Wei Gong, Wei Gong, Xianlin Liu, Xianlin Liu, Yihan Hu, Yihan Hu, Zhili Feng, Zhili Feng, Qiancheng Jing, Qiancheng Jing, Yuexiang Cai, Yuexiang Cai, Sijun Li, Xinzhang Cai, Kai Yuan, Yong Feng, Yong Feng, Yong Feng, Yong Feng, Yong Feng

“…Furthermore, significant alterations were noted in the PI3K-Akt signaling pathway and the calcium signaling pathway, which could potentially influence gap junction function and contribute to hearing loss. …”
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Imaging the large‐scale and cellular response to focal traumatic brain injury in mouse neocortex by Yelena Bibineyshvili, Thomas J. Vajtay, Shiva Salsabilian, Nicholas Fliss, Aastha Suvarnakar, Jennifer Fang, Shavonne Teng, Janet Alder, Laleh Najafizadeh, David J. Margolis

“…Widefield imaging revealed an immediate CCI‐induced activation at the injury site, followed by a massive slow wave of calcium signal activation that travelled across the majority of the dorsal cortex within approximately 30 s. …”
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In vivo spontaneous Ca2+ activity in the pre-hearing mammalian cochlea by Francesca De Faveri, Federico Ceriani, Walter Marcotti

“…However, the origin and interplay of calcium signals during cochlear development is unknown in vivo. …”
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BeatProfiler: Multimodal In Vitro Analysis of Cardiac Function Enables Machine Learning Classification of Diseases and Drugs by Youngbin Kim, Kunlun Wang, Roberta I. Lock, Trevor R. Nash, Sharon Fleischer, Bryan Z. Wang, Barry M. Fine, Gordana Vunjak-Novakovic

“…<italic>Results:</italic> Benchmarking against existing tools revealed that BeatProfiler detected and analyzed contraction and calcium signals better than existing tools through improved sensitivity in low signal data, reduction in false positives, and analysis speed increase by 7 to 50-fold. …”
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Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain by Percival P. D’Gama, Inyoung Jeong, Andreas Moe Nygård, Ahmed Jamali, Emre Yaksi, Nathalie Jurisch-Yaksi

“…Our analyses reveal a reduction in astroglial calcium signals during both spontaneous and light-evoked activity. …”
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Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3 by Jason J. Moore, Shannon K. Rashid, Emmett Bicker, Cara D. Johnson, Naomi Codrington, Dmitri B. Chklovskii, Jayeeta Basu

“…To test this, we imaged in vivo calcium signals from soma, apical dendrites, and basal dendrites in mouse hippocampal CA3 pyramidal neurons during head-fixed navigation. …”
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Targeted Regulation Of Cgrp Gene Expression by A. F. Russo, P. L. Durham

“…We have shown that the duration of the calcium signal is a key determinant for whether a MAP kinase responsive gene will be stimulated or repressed by calcium-activated pathways. …”
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Silica Induces Changes in Cytosolic Free Calcium, Cytosolic pH, and Plasma Membrane Potential in Bovine Alveolar Macrophages by Attila Tárnok, Thomas Schlüter, Ingeborg Berg, Günther Gercken

“…An increase in [Ca2+]i was inhibited, when extracellular Ca2+ was removed. Furthermore the calcium signal was quenched by Mn2+ and diminished by the calcium channel blocker verapamil. …”
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Supralinear dendritic integration in murine dendrite-targeting interneurons by Simonas Griesius, Amy Richardson, Dimitri Michael Kullmann

“…Blocking L-type calcium channels abolished supralinear calcium signalling but only had a minor effect on voltage supralinearity. …”
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Fitting and comparison of calcium-calmodulin kinetic schemes to a common data set using non-linear mixed effects modelling. by Domas Linkevicius, Angus Chadwick, Guido C Faas, Melanie I Stefan, David C Sterratt

“…Calmodulin is a calcium binding protein that is essential in calcium signalling in the brain. There are many computational models of calcium-calmodulin binding that capture various calmodulin features. …”
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UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1−/− Microglia In Vitro and In Vivo by Hye Min Lim, Heo Woon, Jung Woo Han, Yoshihiro Baba, Tomohiro Kurosaki, Min Goo Lee, Joo Young Kim

“…STIM1 function in immune cell calcium signalling has been studied extensively; however, its role in microglia, innate immune cells in brain, has not been fully understood. …”
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Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury by Andrew R. Stevens, Mohammed Hadis, Hannah Alldrit, Michael R. Milward, Valentina Di Pietro, Deena M. A. Gendoo, Antonio Belli, William Palin, David J. Davies, Zubair Ahmed

“…Ribosomal and oxidative phosphorylation pathways and NADH dehydrogenase were downregulated, and there was upregulation of ATP-dependent activity, cAMP and calcium signalling pathways. Key genes in apoptotic pathways were downregulated, as were S100 and cyclo-oxygenase components. …”
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CalciumZero: a toolbox for fluorescence calcium imaging on iPSC derived brain organoids by Xiaofu He, Yian Wang, Yutong Gao, Xuchen Wang, Zhixiong Sun, Huixiang Zhu, Kam W. Leong, Bin Xu

“…However, most of the tools are designed for calcium signal detection only. There are limited choices for in-depth downstream applications, particularly in discerning differences between patient and normal calcium dynamics and their responses to drug treatment obtained from human iPSC-based models. …”
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Evaluation of Preptin and other Biomarkers in Coronary Artery Disease Patients with and without Diabetes Mellitus by Saja T. Yassen, Layla O. Farhan

“…Preprint’s primary metabolic effect is to raise insulin synthesis, which is achieved through both an amplifying mechanism and a triggering route that is dependent on calcium signalling. Objectives: To determine the Preptin in patients with coronary artery disease (CAD) with and without Type 2 diabetes mellitus (T2DM). …”
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Hippocampal dendritic spines store-operated calcium entry and endoplasmic reticulum content is dynamic microtubule dependent by Anastasiya Rakovskaya, Ekaterina Volkova, Ilya Bezprozvanny, Ekaterina Pchitskaya

“…Abstract One of the mechanisms of calcium signalling in neurons is store-operated calcium entry (SOCE), which is activated when the calcium concentration in the smooth endoplasmic reticulum (ER) decreases and its protein-calcium sensor STIM (stromal interacting molecule) relocate to the endoplasmic reticulum and plasma membrane junctions, forms clusters and induces calcium entry. …”
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