CD4+CD25highCD127low/-FoxP3+ Regulatory T-Cell Population in Acute Leukemias: A Review of the Literature by M. Niedźwiecki, O. Budziło, E. Adamkiewicz-Drożyńska, D. Pawlik-Gwozdecka, M. Zieliński, L. Maciejka-Kembłowska, T. Szczepański, P. Trzonkowski

“…The percentage of regulatory T-lymphocytes in peripheral blood and bone marrow was elevated compared to those in healthy individuals and correlated with progressive disease. …”
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Molecular cloning of EZH2 oncogene in chronic myeloid leukemia and therapeutic prospects by Juliana Costa Gaspar, Lucas Santos de Santana, Camila Menezes Freire de Souza, Marcos Montani Caseiro, Rosane Rezende de Souza Giuliani, Cleide Barbieri de Souza

“…Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia, caused in 95 % of the cases by a cytogenetic abnormality characterized by the reciprocal translocation between chromosomes 9 and 22 t(9; 22) (q34; q11), resulting in Philadelphia chromosome (Ph).Considering that CML cure is only possible with a successful bone marrow transplantation and that there are resistance cases to the tyrosine kinase inhibitor Imatinib Mesylate, prescribed in first line drug treatment; it is important to know in detail the genes and proteins that are possibly altered in CML, favoring effective therapeutic strategies, optimized diagnosis and minimal residual disease detection. …”
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In Vitro Differentiation of First Trimester Human Umbilical Cord Perivascular Cells into Contracting Cardiomyocyte-Like Cells by Peter Szaraz, Matthew Librach, Leila Maghen, Farwah Iqbal, Tanya A. Barretto, Shlomit Kenigsberg, Andrée Gauthier-Fisher, Clifford L. Librach

“…Based on the expression of cardiomyocyte markers (cTnT, MYH6, SIRPA, and CX43) FTM and term HUCPVCs achieved significantly increased cardiomyogenic differentiation compared to bone marrow MSCs, while their immunogenicity remained significantly lower as indicated by HLA-A and HLA-G expression and susceptibility to T cell mediated cytotoxicity. …”
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Pathological Role of Tonsillar B Cells in IgA Nephropathy by Yusuke Suzuki, Hitoshi Suzuki, Junichiro Nakata, Daisuke Sato, Tadahiro Kajiyama, Tomonari Watanabe, Yasuhiko Tomino

“…Although impaired immune regulation along the mucosa-bone marrow axis has been postulated to play an important role, the pathogenesis of IgA nephropathy (IgAN) is unknown; thus, no disease-specific therapy for this disease exists. …”
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TiO2 Nanocoatings with Controllable Crystal Type and Nanoscale Topography on Zirconia Implants to Accelerate Bone Formation by Nan Li, Zhichao Liu, Guanqi Liu, Zhi Wang, Xianwei Guo, Chuanbin Guo, Jianmin Han

“…In addition, in vitro cytocompatibility and osteogenic potential performance of the coatings were evaluated by human bone marrow mesenchymal stem cells (hBMSCs), and in vivo osseointegration performance was assessed in a rat femoral condyle model. …”
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Haemophagocytic Lymphohistiocytosis with Leptospirosis: A Rare but Devastating Complication by B. M. Munasinghe, A. G. Arambepola, N. Pathirage, U. P. M. Fernando, N. Subramaniam, S. Nimalan, T. Gajanthan

“…Subsequently, he developed severe acute hypoxemia requiring mechanical ventilation and acute renal failure requiring renal replacement therapy. Bone marrow biopsy and markedly elevated serum ferritin and triglyceride levels done on day 10 (with unresolving fever, hepatosplenomegaly, and pancytopaenia) confirmed the diagnosis of HLH. …”
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Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair by Yuankun Zhai, Zhuang Zhou, Xiaojie Xing, Mark Nuzzle, Xinping Zhang

“…Intermittent rhPTH treatment further enhances the arterial vessel ratio at dura periosteum and type H vessel formation in cortical bone marrow space. Taken together, our study demonstrates a site-dependent coordinated osteogenic and angiogenic response, which is determined by regional osteogenic progenitor pool as well as the coupling blood vessel network at the site of cranial defect repair.…”
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Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen-Specific T Lymphocyte Responses against Melanoma by Zheng Gong, Ming Chen, Jie Miao, Chao-Jie Han, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…We investigated whether CRT/39-272 could induce bone marrow-derived DC maturation and strongly promote the proliferation of OVA-specific T cells in vitro. …”
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Isolated central nervous system relapse in blast crisis of chronic myeloid leukemia: a case report by Hari Priya Raghvan, Caroline Ho Siew Ling, Wee Shiang Yui, Boo Yang Liang, Ehram Jamian, Indhira Subbiah

“…Chronic myeloid leukemia (CML) typically progresses from a chronic phase to an accelerated phase, and eventually to a blast crisis, often involving the bone marrow and peripheral blood, if left untreated. …”
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Evidence of Negative Effects of Defect Size and Older Patient Age by Quantitative CT-Based 3D Image Analysis in Ultraporous Beta-Tricalcium Phosphate Grafted Extremity Bone Defects... by Timothy A. Damron, Kenneth A. Mann

“…Prior clinical studies based on plain X-ray analysis suggest incorporation of TCP is incomplete, even when combined with bone marrow (BMA). Purpose. The purpose was to analyze volumetric CT-based changes in defects grafted with TCP with/without BMA in a completed prospective RCT to objectively determine (1) relationship between size and age versus TCP incorporation and (2) whether there is an advantage to addition of BMA. …”
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Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction by Deping Meng, Yuhong Qin, Nan Lu, Keke Fang, Yuan Hu, Zhigang Tian, Cai Zhang

“…In the present study, HSPC transplantation experiments were used to confirm that adult murine liver HSPCs differentiate into both myeloid cells and lymphocytes (preferentially T cells) compared with bone marrow HSPCs. Using a coculture system comprised of kupffer cells and HSPCs, we found that kupffer cells promote adult liver HSPCs to primarily generate T cells and B cells. …”
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Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue by Ye Seul Park, Md Jamal Uddin, Lingjuan Piao, Inah Hwang, Jung Hwa Lee, Hunjoo Ha

“…Finally, the same phenotypic switch and inflammatory responses were observed in primary bone marrow-derived macrophages from CKO mice. Taken together, the data indicate that endogenous catalase regulates the polarization of adipose tissue macrophages and thereby inhibits inflammation and insulin resistance.…”
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Shuangshen Granules Suppress Myeloid-derived Suppressor Cell-mediated Lung Premetastatic Niche Development by Targeting Sphingosine-1-Phosphate Receptor-1/Signal Transducer, Activa... by Rui Liu, Jia-Qi Hu, Xing Zhang, Xiao-Yi Wu, Hua-Min Wei, Yuan-Chen Zhao, Shu-Lin He, Jing Yu, Xin Qi, Ying-Xia Pei, Hong Chen, Wei-Dong Li, Bao-Jin Hua

“…SSG also suppressed the S1PR1/STAT3 axis in tumor tissues, bone marrow, and lung PMNs. Additionally, SSG suppressed the blood levels of GM-CSF and TGF-β, as well as the PMN markers, matrix metalloproteinase-9 and versican. …”
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Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations by Irene Riezzo, Natascha Pascale, Raffaele La Russa, Arcangelo Liso, Monica Salerno, Emanuela Turillazzi

“…Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide. …”
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Local delivery of TGF-β1-mRNA decreases fibrosis in osteochondral defects by Gianluca Fontana, Brett Nemke, Yan Lu, Connie Chamberlain, Jae-Sung Lee, Joshua A. Choe, Hongli Jiao, Michael Nelson, Margot Amitrano, Wan-Ju Li, Mark Markel, William L. Murphy

“…We designed an mRNA delivery strategy to enhance the natural healing potential of autologous bone marrow aspirate concentrate (BMAC) for articular cartilage repair. …”
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Cathepsin K Deficiency Impaired Ischemia-Induced Neovascularization in Aged Mice by Xueling Yue, Haiying Jiang, Ying Xu, Manli Xia, Xian-Wu Cheng

“…CatK deficiency reduced the levels of cleaved Notch1, phospho-Akt, and/or vascular endothelial growth factor (VEGF) proteins in the ischemic muscles and bone marrow-derived c-Kit+ cells. A flow cytometry analysis revealed that CatK deficiency reduced the numbers of endothelial progenitor cell (EPC)-like CD31+/c-Kit+ cells in the peripheral blood as well as the ischemic vasculature. …”
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Expression of Neural Markers by Undifferentiated Mesenchymal-Like Stem Cells from Different Sources by Dana Foudah, Marianna Monfrini, Elisabetta Donzelli, Stefania Niada, Anna T. Brini, Monia Orciani, Giovanni Tredici, Mariarosaria Miloso

“…The spontaneous expression of neural markers, already demonstrated in bone marrow (BM) mesenchymal stem cells (MSCs), has been considered as evidence of the MSCs’ predisposition to differentiate toward neural lineages, supporting their use in stem cell-based therapy for neural repair. …”
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Radiation-Associated Fracture Nonunion of the Clavicle Treated with Locking Plate Fixation and Autologous Bone Grafting by Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

“…MRI demonstrated a formation of pseudoarthrosis with fluid collection and suggested bone marrow edema at both ends of the fracture fragments. …”
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Comparison of the Efficacy and Safety of PD‐1/PD‐L1 Inhibitors in the Treatment of Small Cell Lung Cancer by Qichen Zhang, Xiaojuan Han, Jiayi Liu, Hui Qiao

“…Adverse effects were comparable between the groups in terms of thyroid function (p = 0.898), but bone marrow suppression and gastrointestinal reactions were significantly less severe in the PD‐L1 group (p = 0.047 and p = 0.002). …”
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Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials by Wei-Chen Huang, Yuan-Chi Li, Pin-Xuan Chen, Kevin Sheng-Kai Ma, Li-Tzu Wang

“…This review delves into the latest advances in MSC-based treatments for chronic and end-stage liver diseases, as highlighted in current clinical trials. MSCs derived from bone marrow and umbilical cord have shown remarkable promise in reversing liver damage, improving liver function, and providing hope for patients who do not respond to conventional therapies. …”
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