Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System by Christian Bucher, Amiq Gazdhar, Lorin M. Benneker, Thomas Geiser, Benjamin Gantenbein-Ritter

“…Human MSCs were harvested from bone marrow aspirate and GDF5 gene transfer was achieved by in vitro electroporation. …”
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B-doped nano-hydroxyapatite facilitates proliferation and differentiation of osteoblasts by Qiao Kang, Wenhao Wang, Shengtao Wu, Ganggang Hu

“…Methods B-nHAp characterization was accomplished by means of X-ray diffraction, scanning electron microscopy, inductively coupled plasma mass spectrometry, and transmission electron microscopy. Human bone marrow mesenchymal stem cells (hBMSCs) were subjected to flow cytometry, alizarin red S staining, and cell counting kit-8 assay for proliferation and differentiation determination. …”
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The Effects of Forodesine in Murine and Human Multiple Myeloma Cells by Liesbeth Bieghs, Jo Caers, Elke De Bruyne, Els Van Valckenborgh, Fiona Higginbotham, Karin Vanderkerken, Eline Menu

“…Multiple myeloma (MM) is the second most commonly diagnosed hematological malignancy, characterized by a monoclonal proliferation of malignant cells in the bone marrow. Despite recent advances in treatment strategies, MM remains incurable and new therapeutical targets are needed. …”
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Initial Cytotoxicity of Mineral Trioxide Aggregate (MTA) during Setting on Human Mesenchymal Stem Cells by Soo-Youn Kim, Su-Min Lee, Jung-Hwan Lee

“…Bone-marrow-derived human mesenchymal stem cells (hMSCs) which are important cell source for hard tissue regeneration stay near periapical lesions of tooth, playing an essential role in periodontal regeneration. …”
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Hypercalcemia, Anemia, and Acute Kidney Injury: A Rare Presentation of Sarcoidosis by Neeraj Sharma, Hassan Tariq, Kalpana Uday, Yevgeniy Skaradinskiy, Masooma Niazi, Sridhar Chilimuri

“…Our Initial impression was likely underlying hematologic malignancy such as lymphoma or multiple myeloma. A bone marrow biopsy was performed that revealed nonnecrotizing granulomatous inflammation. …”
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Application of Mesoporous Silica Nanoparticle-Chitosan-Loaded BMP-2 in the Repair of Bone Defect in Chronic Osteomyelitis by Min Yi, Yu Nie, Chengyun Zhang, Bin Shen

“…In order to test the effectiveness of nanoparticle- (NP-) loaded bone morphogenetic protein 2 (BMP-2) in chronic osteomyelitis (CO) complicated with bone defect, a new nanodrug delivery system composed of mesoporous silica NP (MSN) and chitosan were used to load BMP-2 and transfer it to the target region. Bone marrow mesenchymal stem cells (BMSCs) were purchased and cultivated to detect the osteogenesis of chitosan-MSN (Chi-MSN) and polylactic acid glycolic acid (PLGA) delivery system. …”
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CD4+ T Cells Mediate Dendritic Cell Licensing to Promote Multi‐Antigen Anti‐Leukemic Immune Response by Luis Gil‐de‐Gómez, Joseph J. Mattei, Jessica H. Lee, Stephan A. Grupp, Gregor S. D. Reid, Alix E. Seif

“…In vitro assays confirm the ability of CD4+ T cells from leukemia‐responsive mice to promote robust maturation of naïve bone marrow DC in the presence of non‐immunogenic leukemia antigens. …”
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Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives by Zahra Khosroabadi, Samaneh Azaryar, Hassan Dianat-Moghadam, Zohreh Amoozgar, Mohammadreza Sharifi

“…Abstract Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations leads to a high rate of resistance to current therapies or reduces the efficacy of hematopoietic stem cell transplantation (HSCT), thus increasing the risk of relapse and mortality. …”
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Oxidative Stress and Cytoskeletal Reorganization in Hypertensive Erythrocytes by Ivette Martínez-Vieyra, Isaac Hernández-Rojo, Víctor Hugo Rosales-García, Aracely Evangelina Chávez-Piña, Doris Cerecedo

“…We have previously documented physiological and morphological changes across various blood and bone marrow cell lineages, all of which exhibit elevated oxidative stress. …”
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Pivotal Cytoprotective Mediators and Promising Therapeutic Strategies for Endothelial Progenitor Cell-Based Cardiovascular Regeneration by Hyunyun Kim, Sujin Kim, Sang Hong Baek, Sang-Mo Kwon

“…In response to ischemic injury signals, EPCs located in a bone marrow niche migrate to injury sites and form new vessels by secreting various vasculogenic factors including VEGF, SDF-1, and FGF, as well as by directly differentiating into endothelial cells. …”
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Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture by Olga Schmal, Jan Seifert, Tilman E. Schäffer, Christina B. Walter, Wilhelm K. Aicher, Gerd Klein

“…Here, we describe a simplified 3D hanging drop model for the coculture of cord blood-derived CD34+ hematopoietic stem and progenitor cells (HSPCs) with bone marrow-derived mesenchymal stromal cells (MSCs). …”
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Clinico-hematological and immunophenotypic profile of acute leukemia of ambiguous lineage: A four year experience from a single tertiary care centre of West India by Varnika Rai, Beena Brahmbhatt, Anurag Saha, Immanuel P. Thayakaran

“…Methods and Materials: Patients diagnosed with acute leukemia, preferably their bone marrow aspirate samples, were collected in ethylene diamine tetra-acetic acid-vial. …”
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Exploring the Most Promising Stem Cell Therapy in Liver Failure: A Systematic Review by Jeanne AdiwinataPawitan

“…Among the various adult stem cells that were used in human studies, MSCs from the bone marrow or umbilical cord performed better compared to other types of adult stem cells, though no study showed a complete and sustainable performance in the outcome measures. …”
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Prophylactic intravenous immunoglobulin use in allogeneic stem cell transplantation; does intravenous immunoglobulin affect survival, sepsis, and engraftment time? by Ahmet Kaya, İlhami Berber, İrfan Kuku, Emin Kaya, Mehmet Ali Erkurt, Soykan Biçim, Süleyman Arslan, Fatma Hilal Yağin

“…MATERIALS AND METHODS: In this study, sepsis status, infection focus causing sepsis, neutrophil and platelet engraftment time of patients the length of stay in the hospital at the time of the stem cell transplant, if the patient died, how many days after the transplant the event developed, and the data of the bone marrow transplant unit were reviewed retrospectively. …”
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Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage–myofibroblast transition by Yueyuan Zhou, Zhilan Li, Shenyi Yu, Xuan Wang, Tingting Xie, Weiru Zhang

“…In addition, stimulating bone marrow-derived macrophages with IL-4 and/or iguratimod, or with TGF-β and iguratimod or SRC inhibitors in vitro, suggested that iguratimod mitigates the progression of renal fibrosis in UUO mice, at least in part, by inhibiting the IL-4/STAT6 signaling pathway to attenuate renal M2 macrophage infiltration, as well as by impeding SRC activation to reduce macrophage–myofibroblast transition. …”
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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting. by Kelly Lim, Winnie L Kan, Pramod C Nair, Monika Kutyna, Angel F Lopez, Timothy Hercus, David M Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas

“…Clinically, CBL mutations were associated with increased bone marrow blasts at diagnosis, leukocytosis and splenomegaly, similar to patients harboring NRAS or KRAS mutations. …”
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Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines by Sam Humphries, Sean M. Burnard, Courtney D. Eggins, Simon Keely, Danielle R. Bond, Heather J. Lee

“…However, AML cells targeted by HMA therapy are often quiescent within the bone marrow, where oxygen levels are low. In this study, we investigate the effects of hypoxia on HMA responses in AML cells. …”
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Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer’s Disease Treatment: An In Vitro Study by Nermeen El-Moataz Bellah Ahmed, Masashi Murakami, Yujiro Hirose, Misako Nakashima

“…The results showed that DPSC secretome contains higher concentrations of VEGF, Fractalkine, RANTES, MCP-1, and GM-CSF compared to those of bone marrow and adipose stem cells. Moreover, treatment with DPSC secretome significantly decreased the cytotoxicity of Aβ peptide by increasing cell viability compared to nontreated cells. …”
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Alectinib combined with VRCD and BV monoclonal antibody for the treatment of ALK-positive large B-cell lymphoma: a case report and literature review by Hongxia Wang, Junjun Bai, Bei Zhang, Zhixin Pei, Yingxin Zhao, Jingjing Gu, Zhiyu Fang, Miaomiao Liu, Xun Liang, Qinglin Song

“…Positron emission tomography-computed tomography and a bone marrow examination were carried out after four cycles, revealing a complete response. …”
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Mesenchymal Stem Cells from Human Exfoliated Deciduous Teeth and the Orbicularis Oris Muscle: How Do They Behave When Exposed to a Proinflammatory Stimulus? by Alessander Leyendecker Junior, Carla Cristina Gomes Pinheiro, Daniela Yukie Sakai Tanikawa, José Ricardo Muniz Ferreira, Mariane Tami Amano, Daniela Franco Bueno

“…Although they are classically isolated from the bone marrow, many studies have sought to isolate MSCs from noninvasive sources. …”
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