Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma by Kathleen Overholt, Terri L. Guinipero, Nyla A. Heerema, Michael R. Loken, Samir B. Kahwash

“…In this report, we describe the case of a 2-year-old boy who presented with bone pain and was found to have pancytopenia. Bone marrow examination showed morphologic and immunophenotypic findings typical of APL, but conventional cytogenetics, fluorescence in situ hybridization (FISH), and real-time polymerase chain reaction (RT-PCR) showed no evidence of RARA rearrangements. …”
Get full text

Phospholipogenic Pharmaceuticals Are Associated with a Higher Incidence of Histological Findings than Nonphospholipogenic Pharmaceuticals in Preclinical Toxicology Studies by Linda R. Barone, Scott Boyer, James R. Damewood, James Fikes, Paul J. Ciaccio

“…Histologic findings were tracked for adrenal gland; bone marrow; kidney; liver; lung; lymph node; spleen; thymus; and reproductive organs. …”
Get full text

NGS Analysis of Clonality and Minimal Residual Disease in a Patient with Concurrent Richter’s Transformation and CLL/SLL by Shrihari S. Kadkol, Joshua Bland, Ashley Kavanaugh, Hongyu Ni, Vijeyaluxmi Nehru, David Peace

“…Minimal residual disease analysis by NGS showed that the tumor clone decreased by 2.84 logs in the bone marrow after R-CHOP therapy. However, a small number of tumor cells were still detected in the peripheral blood after R-CHOP therapy. …”
Get full text

Permanent Sensorineural Deafness in a Patient with Chronic Myelogenous Leukemia Secondary to Intracranial Hemorrhage by Sakshi Kapur, Michael Wax, Levin Miles, Adnan Hussain

“…The initial impression was chronic myelogenous leukemia with hyperleukocytosis, and patient was started on hydration, hydroxyurea, and allopurinol. Patient tolerated bone marrow biopsy well but continued to bleed excessively from the biopsy site. …”
Get full text

miR-468-3p suppresses osteogenic differentiation of BMSCs by targeting Runx2 and inhibits bone formation by Tao Fang, Ranxi Zhang, Feng Song, Xueru Chu, Qin Fu, Qianqian Wu

“…Abstract An improved understanding of the molecular actions underpinning bone marrow mesenchymal stem cell (BMSC) differentiation could highlight new therapeutics for osteoporosis (OP). …”
Get full text

Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta by Jamie Geringer, Joshua Fenderson, Michael Osswald

“…She reported adherence to aspirin 81 mg and hydroxyurea 1000 mg daily, and her platelets (375 × 109/L) were at goal. Bone marrow biopsy was consistent with ET without progression to myelofibrosis or leukemia. …”
Get full text

Concomitant Extramedullary Plasmacytoma in the Oropharynx and Hypopharyngeal Squamous Cell Carcinoma by Hiroki Sato, Shoko Yoshimasu, Isaku Okamoto, Akira Shimizu, Yasuaki Katsube, Hideki Tanaka, Kiyoaki Tsukahara

“…Proliferation of plasma cells in the tumor was detected, and a bone marrow puncture test ruled out multiple myeloma leading to a definitive diagnosis of Stage I (cT1N0M0) squamous cell carcinoma in the right piriform recess of the hypopharynx and primary extramedullary plasmacytoma in the oropharynx. …”
Get full text

An Acute Transverse Myelitis Attack after Total Body Irradiation: A Rare Case by Muzaffer Keklik, Leylagul Kaynar, Afra Yildirim, Serdar Sivgin, Celalettin Eroglu, Serife Cingoz, Cigdem Pala, Bulent Eser, Mustafa Cetin, Ali Unal

“…Total body irradiation (TBI) combined with chemotherapy is widely used as a pretreatment regimen of bone marrow transplantation (BMT) in hematologic disorders. …”
Get full text

Assessment of Haematological Parameters in Drug-Resistant TB by Abdulrazzaq Neamah Zghair

“…In addition to the lungs, bone marrow is also impacted by tuberculosis. Significant haematological abnormalities can be found in TB patients. …”
Get full text

A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology. by Manasa Kesapragada, Yao-Hui Sun, Kan Zhu, Cynthia Recendez, Daniel Fregoso, Hsin-Ya Yang, Marco Rolandi, Rivkah Isseroff, Min Zhao, Marcella Gomez

“…Macrophage subtypes are differentiated from primary murine bone marrow derived macrophages using a potent lipopolysaccharide (LPS) or cytokine interleukin-4 (IL-4). …”
Get full text

Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes by Baobing Zhao, Hui Liu, Yang Mei, Yijie Liu, Xu Han, Jing Yang, Amittha Wickrema, Peng Ji

“…We confirm the finding of histone cytosolic release in paraffin‐embedded human bone marrow in vivo. Importantly, we find that patients with myelodysplastic syndrome (MDS) exhibit significant defects in histone release in the dysplastic erythroblasts. …”
Get full text

Ultra-compact quintuple-band terahertz metamaterial biosensor for enhanced blood cancer diagnostics. by Musa N Hamza, Mohammad Tariqul Islam, Sunil Lavadiya, Iftikhar Ud Din, Bruno Sanches, Slawomir Koziel, Syeda Iffat Naqvi, Ali Farmani, Md Shabiul Islam

“…One of the most aggressive forms is blood cancer, originating from bone marrow cells and disrupting the production of normal blood cells. …”
Get full text

Biphasic Chromatin Structure and FISH Signals Reflect Intranuclear Order by Jyoti P. Chaudhuri, Eva Kasprzycki, Mathew Battaglia, John R. McGill, Anton Brøgger, Joachim-U. Walther, Albrecht Reith

“…Materials and Methods: Slides from short term cultures or direct smears of blood, bone marrow and amniotic fluids were hybridized with FISH probes singly, combined or sequentially. …”
Get full text

Association between meniscal extrusion and disease severity in knee osteoarthritis: a retrospective case-control study by Peng Wu

“…Results The study revealed significant associations between severe meniscal extrusion and measures of disease severity, including reduced cartilage thickness(3.24 ± 0.61 versus 3.78 ± 1.45; P = 0.019), increased meniscus degeneration grade (2.86 ± 0.54 versus 2.23 ± 1.63; P = 0.013), diminished joint space width (4.56 ± 0.73 versus 4.86 ± 0.52; P = 0.025), elevated meniscal extrusion(3.68 ± 1.78 versus 2.85 ± 1.54; P = 0.018), greater bone marrow lesion volume(6.13 ± 1.85 versus 5.21 ± 1.58; P = 0.011), advanced cartilage damage(t = 0.016), and impaired physical functioning. …”
Get full text

Development of Delivery Systems Enhances the Potency of Cell-Based HIV-1 Therapeutic Vaccine Candidates by Amin Hadi, Abbas Rastgoo, Maryam Eskandarian, Nooshin Haghighipour, Azam Bolhassani

“…The recent study assessed immune responses generated by MSCs and DCs, which were derived from mouse bone marrow and modified with Nef antigen using novel methods in mice. …”
Get full text

Reparative histogenesis of bone tissue in femoral fractures in rats using biocomposite material along with immunocorrection by V. V. Reshetnyak, V. V. Burdeyniy, V. V. Pronin, Ye. A. Iskaliev

“…The inter-girdle spaces were filled with elements of the myeloid bone marrow in the forming bone tissue. Markedly proliferated osteoblasts were visible in the cambial layer of the periosteum. …”
Get full text

Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines by Bona Linke, Yannick Schreiber, Bettina Picard-Willems, Patrick Slattery, Rolf M. Nüsing, Sebastian Harder, Gerd Geisslinger, Klaus Scholich

“…Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) α secretion out of the monocytes or macrophages. …”
Get full text

Hemophagocytic syndrome: Laboratory and molecular characterization by Nooran Salem Yaseen, Sadiq Khalaf Ali, Hussam Saadi Aziz

“…Thirty-four pediatric and adult patients with peripheral cytopenia attributed to bone marrow (BM) hemophagocytosis enrolled with 34 healthy individuals (age and sex matched) included as a control group. …”
Get full text

Autoimmune Cytopenias in Chronic Lymphocytic Leukemia by Giovanni D'Arena, Roberto Guariglia, Francesco La Rocca, Stefania Trino, Valentina Condelli, Laura De Martino, Vincenzo De Feo, Pellegrino Musto

“…However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity. …”
Get full text

Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions by Ju-Hye Yang, Jae-Myung Yoo, Won-Kyung Cho, Jin Yeul Ma

“…To investigate the effects of ESR treatment on degranulation of IgE/Ag-activated mouse bone marrow-derived mast cells (BMMCs), we measured the release of β-hexosaminidase (β-HEX, degranulation marker). …”
Get full text