Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma by Zoltán Kellermayer, Sabrin Tahri, Madelon M. E. deJong, Natalie Papazian, Cathelijne Fokkema, Elodie C. G. Stoetman, Remco Hoogenboezem, Gregory vanBeek, Mathijs A. Sanders, Louis Boon, Chelsea Den Hollander, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

“…Abstract Malignant plasma cells in multiple myeloma patients reside in the bone marrow and continuously interact with local immune cells. …”
Get full text

Identification of mesenchymal stem cell populations with high osteogenic potential using difference in cell division rate by Maya Watanabe, Yukiyo Asawa, Dan Riu, Tomoaki Sakamoto, Kazuto Hoshi, Atsuhiko Hikita

“…In this study, we aimed to identify a highly osteogenic MSC population by using a similar approach for mouse bone marrow MSCs. Methods: Mouse bone marrow MSCs were fluorescently labeled with carboxyfluorescein succinimidyl ester (CFSE) and sorted according to the fluorescence intensity using flow cytometry on day 3 after labeling. …”
Get full text

Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice by Rose Hilal, Marine Poittevin, Adrien Pasteur-Rousseau, Adrien Cogo, Gabrielle Mangin, Marie Chevauché, Yasmine Ziat, José Vilar, Jean-Marie Launay, Jean-François Gautier, Dong Broquères-You, Bernard I. Levy, Tatyana Merkulova-Rainon, Nathalie Kubis

“…To date, feasibility studies have used bone marrow-derived mononuclear cells, but harvesting bone marrow cells is invasive thus complicating bedside treatment. …”
Get full text

Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice by Ethan P. Glaser, Timothy J. Kopper, William M. Bailey, Hassan K. Kashif, Reena Kumari, Andrew N. Stewart, John C. Gensel

“…Here, we report that cPLA2 plays an important role in the myelin-induced inflammatory macrophage phenotype in vitro using macrophages derived from cPLA2 knockout bone marrow. Furthermore, to investigate the role of cPLA2 in MDMs after SCI, we generated female bone marrow chimeras using cPLA2 knock-out donors and assessed locomotor recovery using the Basso Mouse Scale (BMS), CatWalk gait analysis system, and horizontal ladder task over six weeks. …”
Get full text

MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing by Xiaoning He, Zhiwei Dong, Yina Cao, Han Wang, Shiyu Liu, Li Liao, Yan Jin, Lin Yuan, Bei Li

“…Moreover, we demonstrated that systemically infused bone marrow MSCs (BMMSCs) and jaw bone marrow MSCs (JMMSCs) could translocate to the wound site, promote macrophages toward M2 polarization, and enhance wound healing. …”
Get full text

Stage IV Small Lymphocytic Lymphoma Presenting with Unilateral Vision Loss by Christopher Le, Adam Jacob, Devarajan Iyengar, John Dedousis, Antonios Tsompanidis

“…Small lymphocytic lymphoma (SLL) is a manifestation of chronic lymphocytic leukemia (CLL) in which malignant B-cell lymphocytes accumulate in the lymph nodes or bone marrow. In this report, we describe the medical course of a patient diagnosed with stage IV small cell lymphocytic lymphoma, who presented to the emergency room with acute neurologic manifestations of SLL.…”
Get full text

Colonic Involvement in a Patient with Chronic Lymphocytic Leukaemia by P. E. T. Arkkila, H. Nuutinen, F. Ebeling, E. Elonen, P. Kärkkäinen, M.-L. Karjalainen-Lindsberg

“…If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies.…”
Get full text

Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration by Qiwen Li, Yunshu Wu, Ning Kang

“…Marrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. …”
Get full text

A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia by Masayuki Nagasawa, Yuki Aoki

“…We experienced an 11-year-old boy who presented with systemic lupus erythemathosus (SLE) 10 years after unrelated cord blood transplantation of male origin for juvenile myelomonocytic leukemia (JMML) with monosomy 7. Bone marrow examination showed complete remission without monosomy 7. …”
Get full text

Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation by Ali Mala, Yameena Noman Khan, Akbar Ahmed, Naema Khayyam, Kanwal Aftab

“…Histopathological analysis revealed sheets and aggregates of neoplasm replacing bone marrow interspersed with sclerotic bony fragments. …”
Get full text

Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child by I Gusti Ayu Mardewi, Anak Agung Wiradewi Lestari, I Nyoman Wande, Ni Nyoman Mahartini

“…After the neck lumps resolved, eye swelling began in the right eye and later progressed to the left eye. Bone marrow aspiration confirmed the presence of mixed-lineage leukemia, revealing myeloblasts with Auer rod, monoblast, and lymphoblast. …”
Get full text

A Potential Concept In The Management of Tumors With Modulation of Prostaglandin, Nitric Oxide and Antioxidants by Noori S. Al-Waili

“…We have found in vivo that PGs suppress antibody production; reduce serum iron, and modulate bone marrow function. Tumors are associated with immunosuppression and anemia. …”
Get full text

Amiodarone Pulmonary, Neuromuscular and Ophthalmologic Toxicity by Karen EA Burns, Eugenia Piliotis, Bertha M Garcia, Kathleen A Ferguson

“…Numerous adverse effects have been documented including skin discolouration, photosensitivity, hepatitis, thyroid dysfunction, corneal deposits, pulmonary fibrosis, bone marrow suppression and drug interactions. These side effects are thought to be correlated with the total cumulative dose of amiodarone, but idiopathic reactions have been reported. …”
Get full text

A Case of Abdominal Sarcoidosis in a Patient with Acute Myeloid Leukemia by Vadsala Baskaran, Amanda Goodwin, Lavanya Athithan, Ciro Roberto Rinaldi, Alfredo Addeo

“…The allogeneic bone marrow transplantation usually preceded by induction chemotherapy, in fit patients, represents the gold standard in the acute myeloid leukaemia. …”
Get full text

Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm by Zhenning Wang, Meng Huang, Yu Zhang, Xiaoxia Jiang, Lulu Xu

“…At present, most of the related research is on mesoderm-derived MSCs (M-MSCs) such as bone marrow MSCs and adipose-derived MSCs. As a type of MSC, ectoderm-derived MSCs (E-MSCs) have a stronger potential for self-renewal, multidirectional differentiation, and immunomodulation and have more advantages than M-MSCs in some specific conditions. …”
Get full text

Precursor B Lymphoblastic Lymphoma Involving the Stomach by Masaya Iwamuro, Yoshinari Kawai, Yasuhide Yamawaki, Katsuyoshi Takata, Kazuhide Yamamoto

“…In this report, we present a case of precursor B lymphoblastic lymphoma involving the stomach, pancreas, bone, and bone marrow. Esophagogastroduodenoscopy showed multiple flat elevated lesions with irregular mucosa in the stomach.…”
Get full text

Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction by Yue Liu, Yiqing Yin

“…Neurons in the hippocampus, which is responsible for learning and memory, can be damaged by cytokines transmitted to the brain parenchyma. Microglia, bone marrow-derived macrophages, mast cells, and T cells in the central nervous system (CNS) can be activated to secrete more cytokines, further aggravating neuroinflammation after surgery. …”
Get full text

Global Asymptotic Stability and Hopf Bifurcation for a Blood Cell Production Model by Fabien Crauste

“…This process takes place in the bone marrow,where stem cells differentiate throughout division in blood cells. …”
Get full text

Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report by Ruth C. Angrand, Lauren Telesca, Muhammad Aslam

“…Hemophagocytic lymphohistiocytosis (HLH) is an immune deregulatory disorder resulting in severe inflammation and potentially fatal complications involving the bone marrow, liver, or brain; HLH can be considered primary. …”
Get full text

Effectiveness of Prolotherapy for Chronic Musculoskeletal Conditions by Saurabh Agarwal, Abhishek Nagaich, Nikhil Jain, Arvind Kumar Shah

“…There are several other techniques also such as autologous whole blood, platelet-rich plasma, bone marrow, dry needling, and extracorporeal wave therapy. …”
Get full text