An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome by Saika Sharmeen, Nazia Hussain

“…He simultaneously met the Systemic Lupus International Collaborating Clinics (SLICC) criteria for the diagnosis of systemic lupus erythematosus (SLE) and the diagnostic criteria of HS as described in the hemophagocytic lymphohistiocytosis (HLH) 2004 trial. The bone marrow on autopsy showed the presence of abundant hemosiderophages with focal hemophagocytosis. …”
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A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Occurred in Postchemotherapy of Breast Cancer by Jiankun Tong, Sergei Aksenov, Beth M. Siegel, Lihong Wei, William H. Rodgers

“…BPDCN typically presents with skin lesions and may involve peripheral blood, bone marrow, lymph nodes, or extranodal sites. It usually arises de novo, and some BPDCN cases are associated with or develop into myeloid neoplasms. …”
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Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome by Karthik Nath, Andrew McCann

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The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia by Leena T. Rahmat, Lloyd E. Damon

“…We present a case study of a 76-year-old male with previously untreated CMML, whose hematological parameters remained stable and whose bone marrow blast counts vastly improved while taking papaya leaf extract and dandelion root extract.…”
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Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer by Yue Cao, Xiaokun Gang, Chenglin Sun, Guixia Wang

“…In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.…”
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Pathological investigations on theileriosis caused by theileria annulata in brown calves by Nazır Dumanlı, M. Kemal Çiftçi

“…<p> In the histopathological examination, the following findings were seen; hemorrgahes and necrosis with inflamatory reactions in lymph nodes, necrosis and ulcers in the abomasum, bronchopnumonia and oedema in the lung, interstitial nephritis in the kidneys, increase in the number of lymphocytes in the bone marrow and brain vessels, slight hemorrhages and hypremia in the brain and menings, cell filtration and hemorrhages in the tymus.…”
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Adult acute megakaryoblastic leukemia with persistent diarrhea and extreme thrombocytosis: A very unusual case by Nevin Alayvaz Aslan, Gülsün Gülten

“…The hematologic evaluation included peripheral blood smear, bone marrow aspiration and biopsy, flow cytometry, and cytogenetic analysis. …”
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Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis by Merlin Thomas, Mushtak AlGherbawe

“…Although pulmonary tuberculosis could explain this clinical presentation we suspected associated blood dyscrasias in view of significant monocytosis and mild splenomegaly. Bone marrow aspiration revealed acute myeloid leukemia. …”
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Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence? by Madhu Shukla, Jagdish Chander Mohan

“…Multiparametric flow cytometry of the bone marrow aspirate revealed 20% plasma cells immunophenotyped to produce only light-chain immunoglobulins. …”
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Hematologists/Physicians Need to Be Aware of Pseudohypercalcemia in Monoclonal Gammopathy: Lessons from a Case Report by Svenja F. B. J. Mennens, Ellen Van der Spek, Janneke Ruinemans-Koerts, Marcel M. G. J. Van Borren

“…Examinations showed monoclonal protein, 50% monoclonal plasma cells in bone marrow, and hypercalcemia but no osteolytic bone lesions. …”
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Pivotal Roles of GM-CSF in Autoimmunity and Inflammation by Aoi Shiomi, Takashi Usui

“…Granulocyte macrophage-colony stimulating factor (GM-CSF) is a hematopoietic growth factor, which stimulates the proliferation of granulocytes and macrophages from bone marrow precursor cells. In autoimmune and inflammatory diseases, Th17 cells have been considered as strong inducers of tissue inflammation. …”
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Imaging Molecular Expression on Vascular Endothelial Cells by In Vivo Immunofluorescence Microscopy by Judith M. Runnels, Parisa Zamiri, Joel A. Spencer, Isreal Veilleux, Xunbin Wei, Alexei Bogdanov, Charles P. Lin

“…Other vascular beds such as the bone marrow and ocular blood vessels can be imaged with little or no tissue manipulation. …”
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CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis by David Hiller, Quyen D. Chu

“…CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. …”
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Fine-Tuning Reception in the Bone: PPARγ and Company by Z. Elizabeth Floyd, Sanjin Zvonic, Mark E. Nuttall, Jeffrey M. Gimble

“…In addition, the interplay of PPARγ with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPARγ activity and how these interactions may affect osteogenesis.…”
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Synchronous multiple myeloma and lung adenocarcinoma: A clinical series by Fang Ye, Huan Wang, Ningning Li, Aijun Liu, Wenming Chen

“…Background: Multiple myeloma (MM) is characterised by an increased number of monoclonal immunoglobulin-producing plasma cells that malignantly grow in the bone marrow. Lung cancer is one of the most common malignancies and at the advanced stage may become metastatic to the bone. …”
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Rare Extraperitoneal Involvement with Fatal Outcome in a Case of Bilateral Luteinized Thecoma of the Ovaries with Sclerosing Peritonitis by Mohamed A. Medhat, Mohamed A. Y. Abdel Malek, Saad Zaki, Ahmed Helmy, James J. Driscoll

“…We report the case of a woman diagnosed with bilateral luteinized thecoma of the ovaries with sclerosing peritonitis, multiple intraperitoneal cystic lesions, and extraperitoneal lesions of the liver, inferior to the spleen, and high suspicion of bone marrow involvement. The patient developed profound pancytopenia with rapid clinical deterioration and a fatal outcome.…”
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Leukocytes: The Double-Edged Sword in Fibrosis by Jakub Kryczka, Joanna Boncela

“…Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. …”
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Comparative Evaluation of the Reticulocyte Hemoglobin Content Assay When Screening for Iron Deficiency in Elderly Anemic Patients by Torbjörn Karlsson

“…The aim of this study was to evaluate sensitivity and specificity for reticulocyte hemoglobin content (CHr) compared to other hematimetric and biochemical iron parameters, in particular, mean corpuscular hemoglobin (MCH), when screening for iron deficiency in elderly anemic patients. Bone marrow staining negative for iron was used as the gold standard criterion for iron deficiency anemia (IDA). …”
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Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction by Joselle Cook, Steven Song, Anthony Ventimiglia, Carol Luhrs

“…Extramedullary plasmacytomas (EMPs) are defined by the presence of clonal plasma cell proliferation outside of the bone marrow, portending an overall poor prognosis. This case highlights extramedullary plasmacytomas as an unusual presenting manifestation of multiple myeloma. …”
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Rapid Progression of Plasmacytoma to Multiple Myeloma after Cervical Laminectomy by Dudung Lupito, Paulus Budiono Notodipuro, Raissa Manika Purwaningtyas

“…The results of serum protein electrophoresis showed an increase in the beta fraction with a tapered shape. Bone marrow aspiration examination revealed hypoplastic multiple myeloma. …”
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