Prophylactic phage administration provides a time window for delayed treatment of vancomycin-resistant Enterococcus faecalis in a murine bacteremia model by Wei-Xiao Wang, Jiao-Yang Yu, Xiu-Zhen Chen, Xiu-Zhen Chen, Shi-Yong Fu, Hui Li, Peng-Cheng Yi, Yun-Yao Ren, Shuang-Lin Gu, Jing-Han Gao, Jing Fan, Yan-Mei Sun, Jie Feng, Shi-Wei Wang, Wei Chen, Wei Chen

Get full text

Analysis of early efficacy and immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma by Kaili Chen, Huixin Liang, Zezhong Yu, Guangyao Guo, Huijian Zheng, Yun Huang, Liping Liu, Jie Lin, Jinlan Long, Renyao Pan, Xi Chen, Changgui Wang, Wenjie Zhang, Zhenshu Xu

Get full text

Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

Get full text

Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD by Mengya Zhang, Kun Li, Xiaoxing Huang, Dongqin Xu, Ruobin Zong, Qintong Hu, Xiaoyu Dong, Qinyong Zhang, Chaochen Jiang, Yue Ge, Changyong Li, Jie Ping

Get full text

Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…The current drive towards patient blood management in sub-Saharan Africa (SSA)prescribes that we regulate not only the use of blood transfusion but also the management of patients in whom the cause of iron loss or inadequate iron absorption is sought. …”
Get full text

Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus by Lucrezia Furian, Uwe Heemann, Mats Bengtsson, Oriol Bestard, Isabelle Binet, Georg A. Böhmig, John Boletis, David Briggs, Frans H. J. Claas, Lionel Couzi, Emanuele Cozzi, Marta Crespo, Aiko P. J. De Vries, Fritz Diekmann, Magdalena Durlik, Denis Glotz, Ilkka Helantera, Annette Jackson, Stanley C. Jordan, Dirk Kuypers, Dirk Kuypers, Carmen Lefaucheur, Christophe Legendre, Tomas Lorant, Umberto Maggiore, Nizam Mamode, Smaragdi Marinaki, Annick Massart, Thomas Müller, Rainer Oberbauer, Lutz Renders, Dave Roelen, Jean-Luc Taupin, Ondřej Viklický, Angeliki Vittoraki, Annelies E. de Weerd, Maarten Naesens

Get full text

TWELVE INTRAUTERINE TRANSFUSIONS IN THE EARLY EDEMATOUS FORM OF HEMOLYTIC DISEASE IN BOTH FETUSES WITH DICHORIONIC DIAMNIOTIC TWINS by Антон Валерьевич Михайлов, Алексей Николаевич Кянксеп, Светлана Владимировна Самусь, Анна Антоновна Савельева, Татьяна Александровна Каштанова, Инна Викторовна Кянксеп, Артем Николаевич Романовский

“…Seven intrauterine blood transfusions were consecutively performed to the first fetus and five transfusions to the second ones from 24 weeks of pregnancy. …”
Get full text

Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda by Boniface Amanee Elias Lumori, Daniel Muyanja

“…He received many blood transfusions and hematinics on several occasions during the course of his admissions. …”
Get full text

Porphyria Cutanea Tarda in a Patient with End-Stage Renal Disease: A Case of Successful Treatment with Deferoxamine and Ferric Carboxymaltose by Natacha Rodrigues, Fernando Caeiro, Alice Santana, Teresa Mendes, Leonor Lopes

“…A decision was made to start the patient on ferric carboxymaltose, which was well tolerated without disease symptoms and need of further blood transfusions. This case suggests that deferoxamine is efficient in treatment of porphyria cutanea tarda. …”
Get full text

Coexisting rheumatoid arthritis and sickle cell disease: case series and literature review by Abdallah Alqethami, Sabri Alsaeedi, Samera Felemban, Abdulelah Qadi

“…Four patients had emergency visits or hospitalizations within one year of the diagnosis of RA, but none had blood transfusions, infections, or death. The start of antirheumatic medication was not associated with an increased risk of infection, blood transfusions, emergency visits, or hospitalizations, nor with a worsening of laboratory measures. …”
Get full text

Appropriate Use of Inpatient Erythropoiesis Stimulating Agents by Chenghao Cui, Timothy Nguyen, Mohammad Rattu

“…One dose was dispensed when the Hb was 11.1 g/dL to a patient on renal replacement therapy, and one dose was dispensed when the Hb was 13.8 g/dL to a surgical patient who refused blood transfusions. Among secondary outcomes of interest, there was a difference in blood transfusions administered in critical versus non-critical care settings. …”
Get full text

Spontaneous Complete Remission in a Patient with Acute Myeloid Leukemia and Severe Sepsis by Rambod Mozafari, Mahsa Moeinian, Ali Asadollahi-Amin

“…However, its association with infection and blood transfusions has been described. We report a 53-year-old male who presented with severe sepsis and who was diagnosed with AML (M4). …”
Get full text

Is Hydroxyurea Treatment Changing the Life of Children with Sickle Cell Disease? by Mohammed Ali Al Sabbah, Mahmoud Radaideh, Shafeeka Mohammed Saleh, Sura Ahmed Al-Doory, Amal Mahmoud Abdalqader, Fatima Farid Mir, Aya Mohammed

“…Basic hematologic parameters, frequency of SCD complications, and need for blood transfusions were studied. Results: Our analysis has shown a statistically significant (p < 0.05) correlation between hydroxyurea therapy and improved baseline hemoglobin and HbF levels; it decreased the incidence of painful crises and acute chest syndrome episodes; reduced the demand for blood transfusions; and recorded no side effects (pancytopenia or liver function disturbance). …”
Get full text

Exploring the functional and immune landscape of E-β thalassemia patients through RNA sequencing of peripheral blood mononuclear cells by Nibedita Mitra, Prosanto Chowdhury, Anupam Basu

“…Thalassemia is a hematological disorder caused by mutations in the hemoglobin gene, often necessitating regular blood transfusions. These frequent transfusions exert continuous pressure on patients' immune systems. …”
Get full text

Topical propranolol improves epistaxis in patients with hereditary hemorrhagic telangiectasia - a preliminary report by Meir Mei-Zahav, Hannah Blau, Elchanan Bruckheimer, Eyal Zur, Neta Goldschmidt

“…Outcome measures were epistaxis severity score (ESS), hemoglobin level, and number of blood transfusions prior to and while on treatment. Local and systemic side effects were recorded. …”
Get full text

Cardiac injury caused by iron overload in thalassemia by Chunxi Fu, Chunxi Fu, Xue Yang, Xue Yang

“…Two mechanisms are responsible for iron overload in β-thalassemia: increased iron absorption due to ineffective erythropoiesis and blood transfusions. This review examines the mechanisms of myocardial injury caused by cardiac iron overload and role of various clinical examination techniques in assessing cardiac iron burden and functional impairment. …”
Get full text

Transfusion Thresholds, Quality of Life, and Current Approaches in Myelodysplastic Syndromes by Ioannis Koutsavlis

“…Hemoglobin thresholds and triggers for blood transfusions have changed over the years moving from a higher to a lower level. …”
Get full text

Relationship between Serum Ferritin Levels and Sarcopenia in Transfusion-Dependent Thalassemia Patient by Rendra Prasetya Saefudin, Siprianus Ugroseno Yudho Bintoro, Sony Wibisono Mudjanarko, Merlyna Savitri, Lukita Pradhevi, Agustinus Vincent, Michael Austin Pradipta Lusida, Kartika Afrida Fauzia

“…Introduction: Transfusion-dependent thalassemia (TDT) patients require regular blood transfusions for survival. One of the complications of repeated blood transfusions is iron overload, which occurs when iron accumulates in various organs and causes clinical complications. …”
Get full text

A Rare Case of Chronic Uterine Inversion Secondary to Submucosal Fibroid Managed in the Province Hospital of Nepal by Amit Singh, Rajan Ghimire

“…She was resuscitated with blood transfusions and intravenous fluid. She was posted for emergency surgery where myomectomy was done vaginally, and finally, Haultain’s procedure was carried out. …”
Get full text

Management of Acute Wilsonian Hepatitis with Severe Hemolysis: A Successful Combination of Chelation and MARS Dialysis by Jeremy Hassoun, Nathalie Hammer, Giulia Magini, Belen Ponte, Marie Ongaro, Anne-Laure Rougemont, Nicolas Goossens, Jean-Louis Frossard, Laurent Spahr

“…We report here the case of a young woman who presented with classic acute Wilsonian hepatitis complicated by liver and renal failure and a severe hemolysis related to massive nonceruloplasmin bound copper accumulation requiring repeated blood transfusions. The early initiation of a combined treatment including conventional chelation therapy and repeated MARS dialysis sessions allowed a rapid control of hemolysis, a progressive decrease of free copper overload, and clinical recompensation without liver transplantation.…”
Get full text