Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa by Tandi E. Matsha, Carmen Pheiffer, Stephen E. Humphries, Junaid Gamieldien, Rajiv T. Erasmus, Andre P. Kengne

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Evaluating the potential of assembler-binner combinations in recovering low-abundance and strain-resolved genomes from human metagenomes by Hajra Qayyum, Muhammad Sarfraz Talib, Amjad Ali, Masood Ur Rehman Kayani

“…Due to the inherent limitations of metagenomic assemblers and genome binning tools in recovering low-abundance species (<1 %) and strains, we lack comprehensive insight into these communities. Although many bioinformatics approaches are available for recovering metagenome-assembled genomes, their effectiveness in recovering low-abundance species and strains is often questioned. …”
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Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis by Hongliang Zhang, Tingting Chen, Yunyan Zhang, Jiangbo Lin, Wenjun Zhao, Yangyang Shi, Huichong Lau, Yang Zhang, Minjun Yang, Cheng Xu, Lijiang Tang, Baohui Xu, Jianjun Jiang, Xiaofeng Chen

“…This study was aimed at identifying the genes and molecular mechanisms in aortic dissection through bioinformatics analysis. Method. Nine patients with AD and 10 healthy controls were enrolled. …”
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Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…Given vitamin A’s antioxidant properties and its therapeutic effects on inflammation, this study aims to elucidate how vitamin A influences mitochondrial metabolic reprogramming in inflammatory states, specifically in periodontitis, through genetic bioinformatics and experimental methods.MethodThe study utilized the GSE16134 dataset from the Gene Expression Omnibus (GEO) database, focusing on human periodontitis. …”
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High Performance Frequent Subgraph Mining on Transaction Datasets: A Survey and Performance Comparison by Bismita S. Jena, Cynthia Khan, Rajshekhar Sunderraman

“…Large amounts of graph data are produced in many areas, such as Bioinformatics, Cheminformatics, Social Networks, etc. …”
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Genetics polymorphism of poplars from Moscow region based on high-throughput sequencing of ITS by E. V. Borkhert, G. S. Krasnov, N. L. Bolsheva, Р. Kezimana, O. Yu. Yurkevich, O. V. Muravenko, A. V. Kudryavtseva, N. V. Melnikova

“…Sequencing of ITS of 40 poplar plants was performed on Illumina platform (MiSeq) and about 3 000 reads were obtained for each sample in average. Bioinformatics analysis was performed using CLC Genomics Workbench tool. …”
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Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations by Sarbani Mishra, Preety Sthutika Swain, Sanghamitra Pati, Budheswar Dehury

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Health-related quality of life outcomes reporting associated with FDA approvals in haematology and oncology by Bishal Gyawali, Pallawi Torka, Kristopher Attwood, Medhavi Gupta, Othman Salim Akhtar, Bhavyaa Bahl, Angel Mier-Hicks, Kayla Catalfamo

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Guidelines for the diagnosis and treatment of depressive disorders by integrating Chinese and Western medicine (English edition) by Wei Chen, Wei Li, Yan Li, Zhen Wang, Jianjun Wang, Hongyan Chen, Zhangsheng Yu, Jing Gao, Lin Yu, Yiying Hu, Yongjun Chen, Zhaojun Yan, Lanying Liu, Wangtao Li, Liyuan Luo, Liyuan Guo, Bin Fen, Hongxiao Jia, Zhangjin Zhang

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Pig nasal and rectal microbiotas are involved in the antibody response to Glaesserella parasuis by Pau Obregon-Gutierrez, Yasser Mahmmod, Emili Barba-Vidal, Marina Sibila, Florencia Correa-Fiz, Virginia Aragón

“…Microbiota composition was inferred by V3V4 16S rRNA gene sequencing and bioinformatics analysis, and the antibody response was quantified using the variation between the levels before and after vaccination (normalized per farm). …”
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SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer by Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

“…Abstract Background SLC7A11 is importantly in both ferroptosis and disulfidptosis which participated in human development and homeostasis. By utilizing bioinformatics and in vitro validation, we explored SLC7A11's role in cervical cancer. …”
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Systemic Proteomic Analysis Reveals Distinct Exosomal Protein Profiles in Rheumatoid Arthritis by Qiu Qin, Ronghua Song, Peng Du, Chaoqun Gao, Qiuming Yao, Jin-an Zhang

“…Among them, 32 proteins were significantly upregulated (FC≥2.0 and P<0.05) and 5 proteins were downregulated (FC≤0.5 and P<0.05). Bioinformatics analysis revealed that transthyretin (TTR), angiotensinogen (AGT), lipopolysaccharide-binding protein (LBP), monocyte differentiation antigen CD14 (CD14), cartilage oligomeric matrix protein (COMP), serum amyloid P (SAP/APCS), and tenascin (TNC) can interact with each other. …”
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Endophytic fungi related to the ash dieback causal agent encode signatures of pathogenicity on European ash by Maryam Rafiqi, Chatchai Kosawang, Jessica A. Peers, Lukas Jelonek, Hélène Yvanne, Mark McMullan, Lene R. Nielsen

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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation by Gen Ouyang, Yuangui Zhu, Zhehao Ouyang

“…This study aims to explore the immunotherapeutic mechanism of SBH in treating TC through network pharmacology, bioinformatics analysis, and experimental validation. …”
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Nutrigenomic regulation of sensory plasticity by Hayeon Sung, Anoumid Vaziri, Daniel Wilinski, Riley KR Woerner, Lydia Freddolino, Monica Dus

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A deep learning model based on RGB and hyperspectral images for efficiently detecting tea green leafhopper damage symptoms by Yang Xu, Yilin Mao, He Li, Jiazhi Shen, Xiuxiu Xu, Shuangshuang Wang, Shah Zaman, Zhaotang Ding, Yu Wang

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Production of novel theranostic nano-vector based on superparamagnetic iron oxide nanoparticles/miR-497 targeting colorectal cancer by Asmaa M. Elfiky, May M. Eid, May El-Manawaty, Zeinab A. Elshahid, Elham Mohamed Youssef, Khaled Mahmoud

“…In addition, evaluate the efficiency of this nano-formulation as a therapeutic candidate for CRC. Bioinformatics tools were used to select a promising tumor suppressor miRNA (mir-497-5p). …”
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Rutaecarpine alleviates hepatic ischemia‒reperfusion injury in liver transplantation by inhibiting inflammatory response and oxidative stress by Yan Liu, Yan Liu, Feng Qi, Lun-Jian Xiang, Zhu-Jun Yi, Sheng-Wei Li

“…Mechanistically, bioinformatics analysis and in vivo and in vitro experiments revealed that PDE4B may be a key target by which Rut exerts its protective effect, and molecular docking and cellular thermal shift assay confirmed this result. …”
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Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

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Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia by Xin-Yu Li, Wen-Kai Yu, Jing-Hao Wu, Wen-Jun He, Yu-Nan Cheng, Kai Gao, Yi-Han Wei, Yu-Sheng Li

“…Finally, validation through bioinformatics and animal experiments identified CYP1B1 as a promising biomarker associated with both PD and insomnia.…”
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