KAT2B inhibits proliferation and invasion via inactivating TGF-β/Smad3 pathway-medicated autophagy and EMT in epithelial ovarian cancer by Yuqin Yao, Yuna Niu, Honggui Zhou, Min Yong

“…In vivo, KAT2B silencing increased tumor volume and weight, mitigated by autophagy inhibitor chloroquine. Bioinformatics and co-immunoprecipitation assays identified a KAT2B-SMAD7 interaction. …”
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<i>Macrostomum lignano</i> as a model to study the genetics and genomics of parasitic flatworms by K. V. Ustyantsev, V. Yu. Vavilova, A. G. Blinov, E. V. Berezikov

“…In support of this, we provide the results of our bioinformatics search and analysis of genes homologous between M. lignano and parasitic flatworms, which predicts a list of promising gene targets for subsequent research.…”
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MAGI2-AS3 hypermethylated in promoter region promotes migration and invasion of head and neck squamous cell carcinoma via miRNA-31-5p/AR axis by Kai Yue, Ting Zhang, Huanhuan Wang, Bo Wang, Yalin Mu, Hui Li

“…Molecular regulatory mechanism of MAGI2-AS3 in HNSCC is not yet mature.In this study, we analyzed the methylation level of MAGI2-AS3 promoter and its downstream miR-31-5p/AR axis by bioinformatics methods. qRT-PCR was used to detect the mRNA expression level of each gene, and western blot was used to detect the expression level of AR proteins in tissues and cells. …”
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Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Promote Peritoneal Healing by Activating MAPK-ERK1/2 and PI3K-Akt to Alleviate Postoperative Abdominal Adhesion by Manyu Shi, Hengchen Liu, Tingting Zhang, Mingzhao Zhang, Xin Tang, Zenan Zhang, Wenjun Lu, Shulong Yang, Zhitao Jiang, Qingbo Cui, Zhaozhu Li

“…Related signaling networks were estimated based on sequencing and bioinformatics analyses. The roles of the MAPK–ERK1/2 and PI3K–Akt signaling networks were analyzed using immunoblotting. …”
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The schistosome oesophageal gland: initiator of blood processing. by Xiao-Hong Li, William de Castro-Borges, Sophie Parker-Manuel, Gillian M Vance, Ricardo Demarco, Leandro X Neves, Gareth J O Evans, R Alan Wilson

“…Two further genes, MEGs 4.2 and 14, were shown to be expressed exclusively in the esophageal gland. Bioinformatics predicted that MEGs 4.1 and 4.2 possessed a common hydrophobic region with a shared motif, while antibodies to SjMEG-4.1 showed it was bound to leucocytes in the esophageal lumen. …”
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Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas. by Mengqing Mo, Can Hou, Huangbo Yuan, Renjia Zhao, Mingyang Chen, Yanfeng Jiang, Kelin Xu, Tiejun Zhang, Xingdong Chen, Chen Suo

“…Credible risk variants (CRVs) were combined risk SNPs reported in GWAS Catalog and our study, followed by comprehensive bioinformatics analyses. We identified six novel index SNPs in the progression of SCCs, which were also strongly interacted with fresh fruit intake. …”
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Unique or not unique? Comparative genetic analysis of bacterial O-antigens from the Oxalobacteraceae family by S. D. Afonnikova, A. S. Komissarov, P. D. Kuchur

“…In contrast to existing studies based on PCR methods, we use a bioinformatics approach and compare O- anti gens at the level of clusters rather than individual genes. …”
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An Escin-loaded Glutaraldehyde-Albumin nanoparticle system for enhancing anticancer activity on lung cancer A549 cells by Murugan Alwarkurichi Munusamy, Muruganantham Bharathi, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Samer Hasan Hussein-Al-Ali, Shobana Sampath, Ali Kudumba

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Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation by Günseli Çubukçuoğlu Deniz, Serkan Durdu, Yeşim Doğan, Esra Erdemli, Hilal Özdağ, Ahmet Ruchan Akar

“…After transcriptomic analysis and bioinformatics (n=59), differentially expressed genes were defined using 1.5-fold change as the threshold. …”
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Multi-omics reveals the mechanism of Trimethylamine N-oxide derived from gut microbiota inducing liver fatty of dairy cows by Chenlei Li, Feifei Wang, Yongxia Mao, Yanfen Ma, Yansheng Guo

“…Results We established an in vitro bovine fatty liver cell model and conducted a comprehensive analysis of cells treated with TMAO using high-throughput omics sequencing technologies. Bioinformatics methods were employed to delve into the regulatory effects on lipid metabolism, and several key genes were validated through RT-qPCR. …”
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Explication of Pharmacological Proficiency of Phytoconstituents from Adansonia digitata Bark: An In Vitro and In Silico Approaches by Sangavi P., Gowtham Kumar S., Nachammai KT., Chandrabose Selvaraj, Langeswaran K.

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Molecular Detection and Phylogenetic Analysis of the alkB Gene in Klebsiella oxytoca Strains Isolated from the Gut of Tenebrio molitor by Tsitsi Lynn Mupamhadzi, Oleen Machona, Farisai Chidzwondo, Rumbidzai Mangoyi

“…The primers used in the amplification of the 16S ribosomal RNA region were designed using NCBI, a bioinformatics tool. To detect the presence of the alkB gene in the isolated bacterial strains, a set of primers used in the amplification of this gene was manually designed from the conserved regions of the alkB nucleotide sequences of eleven bacterial species from GenBank. …”
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Pan-genome analysis and expression verification of the maize ARF gene family by Quan-cai Man, Yan-qun Wang, Shun-juan Gao, Zhi-chang Gao, Zheng-ping Peng, Jiang-hui Cui

“…In summary, this study utilizes the maize pan-genome and bioinformatics methods to investigate the evolutionary relationships and functional roles of ARF family members in maize, thereby providing a novel theoretical framework for further research on the maize ARF family.…”
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Domestication of <i>Avena magna</i> Murphy et Terrell: a wild tetraploid oat species endemic of Morocco by N. Saidi, N. Shaimi, A. S. Idrissi, A. Souihka, F. Gaboun, C. Al Faiz, G. Ladizinsky

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Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer. by Yinghao He, Fuqiang Liu, Qingshu Li, Zheng Jiang

“…Through functional analysis and bioinformatics methods, we elucidated pathway differences and biological characteristics between these two subtypes. …”
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Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer by Zhaoda Deng, Lincheng Li, Zihe Meng, Guineng Zeng, Rui Cao, Rong Liu

“…Therefore, comprehensive bioinformatics analysis of pan-cancer was performed to determine the mechanisms through which TNFSF4 regulates tumorigenesis. …”
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Technical considerations towards commercialization of porcine respiratory and reproductive syndrome (PRRS) virus resistant pigs by A. Mark Cigan, Pieter W. Knap

“…Rather than backcrossing the resistance gene from a few non-commercial founders, as a global supplier of high genetic merit livestock genetics, Genus plc and its pig division PIC (Pig Improvement Company) with Genus R&D have mobilized advances in reproductive biology, gene editing, DNA sequencing, and bioinformatics to simultaneously generate and introduce a single modified CD163 allele across four genetically diverse porcine lines of commercial importance that prevents PRRS virus (PRRSV) infection. …”
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Drug Target Investigation of <i>N</i>-<i>p</i>-Coumaroyl-<i>N</i>’-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from <i>Saxifraga tangutica</i> by Chuang Liu, Jun Dang, Minchen Wu

“…To further identify its target, the drug affinity responsive target stability technique and multiple public databases were integrated to retrieve a total of 317 common targets from comprehensive screening. A further bioinformatics analysis not only identified 13 hub targets but also indicated PCC as having biological activities against cancer and affecting metabolic diseases. …”
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Targeting AURKA with multifunctional nanoparticles in CRPC therapy by Bin Deng, Binghu Ke, Qixing Tian, Yukui Gao, Qiliang Zhai, Wenqiang Zhang

“…This study investigates the efficacy of ART-T cell membrane-encapsulated AMS@AD (CM-AMS@AD) nanoparticles (NPs) in a photothermal–chemotherapy–immunotherapy combination for CRPC. Bioinformatics analysis of the Cancer Genome Atlas-prostate adenocarcinoma (TCGA-PRAD) dataset revealed overexpression of AURKA in PCa, correlating with poor clinical outcomes. …”
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Molecular Characterization of the CYTB Gene of Radix auricularia Linnaeus, 1758 (Mollusca, Gastropoda, Lymnaeidae) in Al-Chibayish of Thi-Qar Province, Southern Iraq by Sarmad A. M. Al-Asadi

“…For sequencing, four purified PCR products (approximately 400 bp) were randomly selected for each station. The bioinformatics results showed that the mitochondrial genome of R. auricularia contained 24 non-protein-coding genes and 13 protein-coding genes, including CYTB, NAD5, NAD6 and NAD4L. …”
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