Peptide-Based Vaccination Therapy for Rheumatic Diseases by Bin Wang, Shiju Chen, Qing Zheng, Yuan Liu, Guixiu Shi

“…Nevertheless, advances in high-throughput technology, bioinformatics, and nanotechnology may help overcome these impediments and facilitate the successful development of peptide-based vaccination therapy for rheumatic diseases.…”
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Protocol for quantifying muscle fiber size, number, and central nucleation of mouse skeletal muscle cross-sections using Myotally software by Pieter Both, Soochi Kim, Jengmin Kang, Marina Arjona, Daniel I. Benjamin, Christopher W. Nutter, Armon Goshayeshi, Thomas A. Rando

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Biotechnology breakthroughs: Revolutionizing oral cancer treatment by Safin Hussein, Karzan Qurbani, Haider Hamzah, Seenaa Ali, Sirwan Khalid Ahmed

“…Integration with advanced bioinformatics and artificial intelligence enables precision medicine tailored to individual tumors. …”
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Comprehensive Analysis Identifies <i>THEMIS2</i> as a Potential Prognostic and Immunological Biomarker in Glioblastoma by Jianan Chen, Qiong Wu, Anders E. Berglund, Robert J. Macaulay, Arnold B. Etame

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A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of Triphala by Santhosh N. Hegde, Lavanya Devi K, Mahima Choudhary, Nandita Menon, Gurmeet Singh

“…LCMS/MS data analysis was performed on the resultant metabolites, with bioinformatics tools employed for pathway enrichment, target prediction, and classification of identified compounds. …”
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Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration by Junyu Zhang, Yu Zhou

“…As expected, several ophthalmic disease-related molecules, including RHO, PDE6A, 3′,5′-cyclic-GMP phosphodiesterase, and G protein alpha, were in the central nodes of disease network. The bioinformatics technology combined with the existing high-throughput data was applied to evaluate the underlying key genes and pathways in human AMD tissues, which may predict downstream and upstream biological processes and identify potential therapeutic intervention targets in human AMD.…”
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hsa_circRNA_000166 Facilitated Cell Growth and Limited Apoptosis through Targeting miR-326/LASP1 Axis in Colorectal Cancer by Qin Hao, Zhongtao Zhang

“…Furthermore, we identified that hsa_circRNA_000166 targeted the miR-326/LASP1 pathway using bioinformatics analysis and luciferase reporter assay. …”
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Comprehensive RNA-seq analysis of benign prostatic hyperplasia (BPH) in rats exposed to testosterone and estradiol by Xiao-Hu Tang, Zhi-Yan Liu, Jing-Wen Ren, Heng Zhang, Ye Tian, Jian-Xin Hu, Zhao-Lin Sun, Guang-Heng Luo

“…We used RNA-seq and bioinformatics to detect differentially expressed genes (DEGs) between the prostate tissue of the novel benign prostatic hyperplasia rat group and the control group, including 458 DEGs, of which 336 were upregulated and 122 were downregulated. …”
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Osthole regulates N6‐methyladenosine‐modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease by Xian Lin, Jian Chen, Cheng Tao, Lianxiang Luo, Juan He, Qingwen Wang

“…Furthermore, OS restrained the proliferation and polarization of M2 macrophages to inhibit the aggregation of lung interstitial CD11b+ macrophages, and the effectiveness and non‐toxicity of OS in suppressing RA and RA‐ILD progression were verified in vivo. Finally, bioinformatics analyses validated the importance and the clinical significance of the OS‐regulated molecular network. …”
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Construction of a pathogenic microorganism detection method based on third-generation nanopore sequencing data by Guoqin Mai, Jiayi Chen, Min Zhang, Wanyue Zhang, Yuting Luo, Ying Dai

“…Methods In this study, a bioinformatics pipeline was developed. First, a comprehensive and penetrating reference database of nucleic acids from pathogenic microorganisms was constructed, and sequence alignment analysis was performed via nanopore sequencing of metagenomic data collected from 40 patients with lower respiratory tract infection symptoms. …”
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Deciphering mixed infections by plant RNA virus and reconstructing complete genomes simultaneously present within-host. by Martine Bangratz, Aurore Comte, Estelle Billard, Abdoul Kader Guigma, Guillaume Gandolfi, Abalo Itolou Kassankogno, Drissa Sérémé, Nils Poulicard, Charlotte Tollenaere

“…To this end, we tested different sequencing strategies, and we finally combined direct cDNA ONT (Oxford Nanopore Technology) sequencing with the bioinformatics tool RVhaplo. This method was validated by the successful reconstruction of two viral genomes that were less than a hundred nucleotides apart (out of a genome of 4450nt length, i.e. 2-3%), and present in artificial mixes at a ratio of up to a 99/1. …”
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Beyond boundaries: Charting the frontier of healthcare with big data and ai advancements in pharmacovigilance by Arohi Agarwal, Gagan Singh, Samyak Jain, Piyush Mittal

“…It delves into the notable benefits and challenges encountered in advancing data analytics of the early 21st century.In many countries, Post-marketing surveillance of drug safety relinquishes on a systematic analysis of spontaneous using Generative artificial intelligence (AI) to overcome gaps in the present PV ecosystem is critical to maintaining an uninterrupted record of security and effectiveness within healthcare analytics, data mining techniques, predictive analytics, and the emergence of scientific fields like bioinformatics and health informatics are empowered by Big Data. …”
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Protocol for fecal microbiota transplantation: A microaerophilic approach for mice housed in a specific pathogen-free facility by Shari Wouters, Hugo Moors, Mieke Verslegers, Natalie Leys, Surbhi Malhotra-Kumar, Samir Kumar-Singh, Mohamed Mysara

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Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines by Aziz A. Chentoufi, Jeffrey B. Ulmer, Lbachir BenMohamed

“…This review will (1) present the current state of antigen delivery platforms involving a multifaceted approach, including bioinformatics, molecular and structural biology, immunology, and advanced computational methods; (2) discuss the challenges facing the development of safe and effective antigen delivery platforms; and (3) highlight the potential of nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNP) as the platform that is well suited to the needs of a next-generation pan-CoV vaccine, such as the ability to induce broad-based immunity and amenable to large-scale manufacturing to safely provide durable protective immunity against current and future Coronavirus threats.…”
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Optical wave features and sensitivity analysis of a coupled fractional integrable system by Jan Muhammad, Usman Younas, D.K. Almutairi, Aziz Khan, Thabet Abdeljawad

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Characterizing microbial communities and their correlation with genetic mutations in early-stage lung adenocarcinoma: implications for disease progression and therapeutic targets by Hao-Shuai Yang, Jin Zhang, Hong-Xiang Feng, Fei Qi, Fan-Jia Kong, Wei-Jie Zhu, Chao-Yang Liang, Zhen-Rong Zhang

“…Whole exome sequencing was performed to identify somatic mutations and genetic variants. Bioinformatics analysis, including taxonomic annotation with Kraken2 and de novo assembly with MEGAHIT, was conducted to process metagenomic data. …”
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Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Childr... by Jason Glover, Tsz-Kwong Man, Donald A Barkauskas, David Hall, Tanya Tello, Mary Beth Sullivan, Richard Gorlick, Katherine Janeway, Holcombe Grier, Ching Lau, Jeffrey A Toretsky, Scott C Borinstein, Chand Khanna, Timothy M Fan, COG Osteosarcoma Biology Group

“…The continued population of the HDD platform with high-value, high-throughput and mineable datasets allows a shared and reusable resource for researchers, both experimentalists and bioinformatics investigators, to propose and answer questions in silico that advance our understanding of osteosarcoma biology.…”
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Identification of Ethnically Specific Genetic Variations in Pan-Asian Ethnos by Jin Ok Yang, Sohyun Hwang, Woo-Yeon Kim, Seong-Jin Park, Sang Cheol Kim, Kiejung Park, Byungwook Lee

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Transcriptional regulation by CHIP/LDB complexes. by Revital Bronstein, Liron Levkovitz, Nir Yosef, Michaela Yanku, Eytan Ruppin, Roded Sharan, Heiner Westphal, Brian Oliver, Daniel Segal

“…Here we use the powerful genetics of Drosophila combined with microarray and bioinformatics analyses to tackle this challenge. The nuclear adaptor CHIP/LDB is a major developmental regulator capable of forming tissue-specific transcription complexes with various types of transcription factors and cofactors, making it a valuable model to study the intricacies of gene regulation. …”
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Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy by Jie Ma, Hongtao Wang, Zhengwei Gui, Yuanrong Yang

“…The effect of SYNGR4 on breast cancer prognosis was analyzed using bioinformatics and possible pathways by which this molecule affects breast cancer prognosis were explored. …”
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