circRNA18_46222157_46248185 inhibits melanogenesis by targeting miR-211/ pathway in goat melanocytes by Kai Yuan Ji, Xue Qing Zhang, Yi Wei Zhao, Chun E Liang, Xin Yuan, Yun Hai Zhang

“…The circRNA18 interference vector was designed and synthesized to transfect melanocytes and detect the effect of circRNA18 interference on melanin production. Bioinformatics software was used to predict the targeted adsorption miRNAs of circRNA18, verified by luciferase assay. …”
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Preclinical model for evaluating human TCRs against chimeric syngeneic tumors by Olivier Michielin, Philippe Guillaume, Melita Irving, Patrick Reichenbach, Vincent Zoete, Elise Gray-Gaillard, Evangelos Stefanidis, Aikaterini Semilietof, Julien Pujol, Alessia D'Esposito

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Altered zygotic gene expression caused by sperm with Tdrd6 variants disrupts early embryonic development by Zhijie Hu, Yuqi Zhang, Renfei Cai, Qiuju Chen, Haiyan Guo, Danjun Li, Weidong Lin, Hongxi He, Haibo Wu, Yali Liu, Bin Li, Qianwen Xi, Hongyuan Gao, Jian Zhang, Qifeng Lyu, Yanping Kuang, Xuefeng Lu

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Deciphering the role of flutamide, fluorouracil, and furomollugin based ionic liquids in potent anticancer agents: Quantum chemical, medicinal, molecular docking and MD simulation... by Danish Ali, Muhammad Arif Ali, Muhammad Sarfraz, Afifa Yousuf, Rasham Zulfiqar, Abdul Rauf, Hong-Liang Xu, Muhammad Arshad

“…Thus, these analyses confirm that the newly identified ILs exhibit superior binding affinities and acceptable bioinformatics profiles, making them attractive candidates for the development of anticancer drugs.…”
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Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies by Touhidul Islam Tanim, Ayman M. Al-Qaaneh, Raihan Chowdhury, Md. Shimul Bhuia, Tabassum Islam, Md Showkoth Akbor, Md. Tahajul Islam, Md. Mohasin Miah, Ali Raza Ishaq, Mostafa A. Abdel-Maksoud, Mohamed A. El-Tayeb, Mohamed El-Shazly, Muhammad Torequl Islam, Heba A.S. El-Nashar

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A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation by Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng

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IMA genome‑F17 by Brenda D. Wingfield, Dave K. Berger, Martin P. A. Coetzee, Tuan A. Duong, Anke Martin, Nam Q. Pham, Noelani van den Berg, P. Markus Wilken, Kiruba Shankari Arun-Chinnappa, Irene Barnes, Sikelela Buthelezi, Buddhika Amarasinghe Dahanayaka, Alvaro Durán, Juanita Engelbrecht, Alice Feurtey, Arista Fourie, Gerda Fourie, Jesse Hartley, Eugene N. K. Kabwe, Mkhululi Maphosa, Deborah L. Narh Mensah, David L. Nsibo, Lizel Potgieter, Barsha Poudel, Eva H. Stukenbrock, Chanel Thomas, Niloofar Vaghefi, Tanya Welgemoed, Michael J. Wingfield

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Functional and developmental convergence in the reproductive “nurse cells” of flowering plants by Doll, Nicolas Max, Truskina, Jekaterina, Ingram, Gwyneth

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Probiotics, Prebiotics, and Synbiotics: Gut and Beyond by Usha Vyas, Natarajan Ranganathan

“…Microbiomics has spurred a dramatic increase in scientific, industrial, and public interest in probiotics and prebiotics as possible agents for gut microbiota management and control. Genomics and bioinformatics tools may allow us to establish mechanistic relationships among gut microbiota, health status, and the effects of drugs in the individual. …”
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Algorithms for Processing Coronavirus Genomes for the Goals and Objectives of Modern Immunoinformatics, Vaccinomics, and Virology by M. V. Sprindzuk, A. S. Vladyko, L. P. Titov, Lu Zhuozhuang, V. I. Bernik

“…The novel coronavirus pandemic has stimulated the scientific activity of virology and interdisciplinary sciences: medical cybernetics and bioinformatics. The article is focused on the study of algorithms for processing bioinformatic data of genomic origin predominantly for the purposes of predominantly immunoinformatics and computational vaccinology. …”
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A Method for Bio-Sequence Analysis Algorithm Development Based on the PAR Platform by Haipeng Shi, Huan Chen, Qinghong Yang, Jun Wang, Haihe Shi

“…The problems of biological sequence analysis have great theoretical and practical value in modern bioinformatics. Numerous solving algorithms are used for these problems, and complex similarities and differences exist among these algorithms for the same problem, causing difficulty for researchers to select the appropriate one. …”
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RNA Editing and Drug Discovery for Cancer Therapy by Wei-Hsuan Huang, Chao-Neng Tseng, Jen-Yang Tang, Cheng-Hong Yang, Shih-Shin Liang, Hsueh-Wei Chang

“…In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.…”
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RhoA Regulation of Cardiomyocyte Differentiation by Mari Kaarbø, Denis I. Crane, Wayne G. Murrell

“…Comparative analysis indicated strict conservation of both gene organisation and coding sequence of the chick, mouse, and human RhoA genes. Bioinformatics analysis of the derived promoter region of mouse RhoA identified putative consensus sequence binding sites for several transcription factors involved in heart formation and organogenesis generally. …”
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Training data diversity enhances the basecalling of novel RNA modification-induced nanopore sequencing readouts by Ziyuan Wang, Ziyang Liu, Yinshan Fang, Hao Helen Zhang, Xiaoxiao Sun, Ning Hao, Jianwen Que, Hongxu Ding

“…Abstract Accurately basecalling sequence backbones in the presence of nucleotide modifications remains a substantial challenge in nanopore sequencing bioinformatics. It has been extensively demonstrated that state-of-the-art basecallers are less compatible with modification-induced sequencing signals. …”
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M-Polynomial and NM-Polynomial Methods for Topological Indices of Polymers by Mohammed Yasin H, M. Suresh, Zebene G. Tefera, Samuel A. Fufa

“…Topological indices (TIs) are numerical tools widely applied in chemometrics, biomedicine, and bioinformatics for predicting diverse physicochemical attributes and biological activities within molecular structures. …”
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Reinforcement Learning with Probabilistic Boolean Network Models of Smart Grid Devices by Pedro Juan Rivera Torres, Carlos Gershenson García, María Fernanda Sánchez Puig, Samir Kanaan Izquierdo

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Unraveling the metabolic landscape of Exophiala spinifera strain FM: Model reconstruction, insights into biodesulfurization and beyond. by Hamta Babaei Naeij, Zahra Etemadifar, John Kilbane, Mohammad Hossein Karimi-Jafari, Sepideh Mofidifar

“…In this study, we sequenced the complete genome of E. spinifera FM to construct the first genome-scale metabolic model (GSMM) for this organism. Through bioinformatics analysis, we identified genes potentially involved in DBT desulfurization and degradation pathways for hazardous pollutants. …”
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Editorial: Community series in towards precision medicine for immune-mediated disorders: advances in using big data and artificial intelligence to understand heterogeneity in infla... by Xu-jie Zhou, Xu-jie Zhou, Xu-jie Zhou, Xu-jie Zhou, Xu-jie Zhou, Yasmina Laouar, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi

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TOPPER: Topology Prediction of Transmembrane Protein Based on Evidential Reasoning by Xinyang Deng, Qi Liu, Yong Hu, Yong Deng

“…The topology prediction of transmembrane protein is a hot research field in bioinformatics and molecular biology. It is a typical pattern recognition problem. …”
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Environmental DNA and its role in identifying yeast biodiversity in mangrove ecosystem: A literature review by Kusuma Rahayu Lila, Retnaningsih Soeprobowati Tri, Warsito Budi

“…Future research should focus on understanding eDNA persistence, ecological implications, and improving bioinformatics for better data interpretation. In-depth long-term studies are recommended to study the temporal and spatial dynamics of yeast communities in mangrove ecosystems. …”
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