Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies by Ekaterina S. Porfireva, Anton D. Zadorozhny, Anastasia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Alexey A. Lagunin

“…SSPR models were created for each protein using the MultiPASS software based on the Bayesian algorithm and different levels of MNA (Multilevel Neighborhoods of Atoms) descriptors for the representation of structural formulas of protein fragments including AAS.ResultsThe accuracy of prediction was assessed through a 5-fold cross-validation and compared to other bioinformatics tools, such as SIFT4G, Polyphen2 HDIV, FATHMM, MetaSVM, PROVEAN, ClinPred, and Alpha Missense. …”
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Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients by Mahnoor N. Gondal, Marcin Cieslik, Arul M. Chinnaiyan

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Common Expression Quantitative Trait Loci Shared by Histone Genes by Hanseol Kim, Yujin Suh, Chaeyoung Lee

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Optimal Dual RNA-Seq Mapping for Accurate Pathogen Detection in Complex Eukaryotic Hosts by Infanta Eden M., Umashankar Vetrivel

“…Existing analysis methods employ various combinations of open-source bioinformatics tools to process dual RNA-Seq data. Upon reviewing these methods, we intend to explore crucial criteria for selecting standard tools and methods, especially focusing on critical steps such as trimming and mapping reads to the reference genome. …”
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Evaluation of the Cytotoxic Effects of CAM Therapies: An In Vitro Study in Normal Kidney Cell Lines by Shagun Arora, Chanderdeep Tandon, Simran Tandon

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Author Correction: AIVariant: a deep learning-based somatic variant detector for highly contaminated tumor samples by Hyeonseong Jeon, Junhak Ahn, Byunggook Na, Soona Hong, Lee Sael, Sun Kim, Sungroh Yoon, Daehyun Baek

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The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes by Yuanyuan Gui, Geyu Zhou, Shuya Cui, Hongyu Li, Hui Lu, Hongyu Zhao

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Google trend analysis of the Indian population reveals a panel of seasonally sensitive comorbid symptoms with implications for monitoring the seasonally sensitive human population by Urmila Gahlot, Yogendra Kumar Sharma, Jaichand Patel, Sugadev Ragumani

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Molecular mechanisms underlying age-dependent effects of rearing system on the goose testicular development and semen quality by Shenqiang Hu, Xiaopeng Li, Enhua Qing, Junqi Wang, Qingliang Chen, Yang Song, Jiasen Chen, Jiwei Hu, Liang Li, Jiwen Wang

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Embracing Integrative Multiomics Approaches by Daniel M. Rotroff, Alison A. Motsinger-Reif

“…As “-omics” data technology advances and becomes more readily accessible to address complex biological questions, increasing amount of cross “-omics” dataset is inspiring the use and development of integrative bioinformatics analysis. In the current review, we discuss multiple options for integrating data across “-omes” for a range of study designs. …”
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Effects of Pooling Samples on the Performance of Classification Algorithms: A Comparative Study by Kanthida Kusonmano, Michael Netzer, Christian Baumgartner, Matthias Dehmer, Klaus R. Liedl, Armin Graber

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A Bayesian Adaptive Design in Cancer Phase I Trials Using Dose Combinations in the Presence of a Baseline Covariate by Márcio Augusto Diniz, Sungjin Kim, Mourad Tighiouart

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Protein Backbone Torsion Angle-Based Structure Comparison and Secondary Structure Database Web Server by Sunghoon Jung, Se-Eun Bae, Insung Ahn, Hyeon S. Son

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Survival Analysis by Penalized Regression and Matrix Factorization by Yeuntyng Lai, Morihiro Hayashida, Tatsuya Akutsu

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Coomassie Brilliant Blue Induces Coiled-Coil Aggregation in Lysozyme at pH 7.4 by Hydrophobic and Electrostatic Forces by Ajamaluddin Malik, Javed Masood Khan, Priyankar Sen, Abdulaziz Alamri, Rohit Karan, Arnold Emerson I

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Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease by David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson

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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

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Tell me y: anticipation of sex discrepancies in cell-free DNA testing due to maternal genetic abnormalities: a case report by Nuria Balaguer, Emilia Mateu-Brull, Jose Antonio Martínez-Conejero, Ana Cervero, Roser Navarro, Jorge Jiménez-Almazán, Miguel Milán

“…We used Illumina’s VeriSeq NIPT Solution v2 and a proprietary bioinformatics pipeline to analyze cfDNA in the maternal bloodstream. …”
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Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

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