3-Epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma by Mengjie Liu, Xuqiang Liu, Kaiyue He, Yongping Jian, Yujia Li, Jinrong Guo, Jingyu Yang, Zhixiang Xu, Wenyi Kang

“…Application of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP, activation of AMP-activated protein kinase (AMPK), and inhibition of mTOR. …”
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Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype by Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa Chapa, Karthik Ramachandran, Rahul S. Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh

“…Significantly, in M1 macrophages, Mg2+ entry is facilitated by a novel Mg²-dependent current that relies on extracellular Mg2+, which was crucial for activating iNOS/NFκB pathways and cellular bioenergetics, which drives pro-inflammatory cytokines. …”
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Temperature- and ontogeny-dependent metabolism in invasive early juvenile round goby (Neogobius melanostomus) by Hunter A. Herron, Sina Zarini, William Andrew Thompson, Andy J. Turko, Sigal Balshine

“…We also found that the bioenergetics models previously developed for adults do not effectively translate to juveniles; the current models underestimated observed RMR values by ~20–60% depending on temperature. …”
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Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone by Sergio Perez-Alvarez, Maria E. Solesio, Maria D. Cuenca-Lopez, Raquel M. Melero-Fernández de Mera, Carlos Villalobos, Hanna Kmita, Maria F. Galindo, Joaquin Jordán

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Development of a TSR-based method for understanding structural relationships of cofactors and local environments in photosystem I by Lujun Luo, Tarikul I. Milon, Elijah K. Tandoh, Walter J. Galdamez, Andrei Y. Chistoserdov, Jianping Yu, Jan Kern, Yingchun Wang, Wu Xu

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Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside by Sidra Tabassum, Silin Wu, Chang-Hun Lee, Bosco Seong Kyu Yang, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren

“…We discuss the underlying mechanisms of mitochondrial damage in TBI, including oxidative stress, impaired bioenergetics, mitochondrial dynamics, and apoptotic pathways. …”
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De Novo Assembly of the Polyhydroxybutyrate (PHB) Producer <i>Azohydromonas lata</i> Strain H1 Genome and Genomic Analysis of PHB Production Machinery by Daniele Traversa, Carlo Pazzani, Pietro D’Addabbo, Lucia Trisolini, Matteo Chiara, Marta Oliva, Angelo Marzella, Camilla Mandorino, Carla Calia, Guglielmina Chimienti, Caterina Manzari, Graziano Pesole, Maria Scrascia

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Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb by Danielle M. Colussi, Ryan Grainger, Megan Noble, Taylor Lake, Murray Junop, Peter B. Stathopulos

“…The regulatory mechanisms of the mitochondrial calcium uniporter complex (mtCU), the predominant channel mediating calcium (Ca2+) flux into the matrix, are critical for bioenergetics and cell fate. The pore-forming components of mtCU are the mitochondrial Ca2+ uniporter (MCU) subunit and the MCU dominant-negative beta (MCUb) subunit. …”
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V-ATPase in glioma stem cells: a novel metabolic vulnerability by Alessandra Maria Storaci, Irene Bertolini, Cristina Martelli, Giorgia De Turris, Nadia Mansour, Mariacristina Crosti, Maria Rosaria De Filippo, Luisa Ottobrini, Luca Valenti, Elisa Polledri, Silvia Fustinoni, Manuela Caroli, Claudia Fanizzi, Silvano Bosari, Stefano Ferrero, Giorgia Zadra, Valentina Vaira

“…Here we studied how patients-derived GSCs rely on V-ATPase activity to sustain mitochondrial bioenergetics and cell growth. Methods V-ATPase activity in GSC cultures was modulated using Bafilomycin A1 (BafA1) and cell viability and metabolic traits were analyzed using live assays. …”
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Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

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Effects of olive leaf extract on exercise performance and muscle mitochondrial response in young healthy adults by Clément Lanfranchi, Nadège Zanou, Jérôme Feige, Umberto DeMarchi, Aurélie Hermant, Ornella Cominetti, Eugenia Migliavacca, Alba Moreno-Asso, Astrid Hostrman, Sara Mistro, Nicolas Place

“…We have previously shown that this is at least partially driven by improved skeletal muscle mitochondrial bioenergetics with increased mitochondrial Ca2+ uptake and pyruvate dehydrogenase (PDH) activation after a single session of SIT but not MICT [1]. …”
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The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis by Peilu She, Bangjun Gao, Dongliang Li, Chen Wu, Xuejiao Zhu, Yuan He, Fei Mo, Yao Qi, Daqing Jin, Yewei Chen, Xin Zhao, Jinzhong Lin, Hairong Hu, Jia Li, Bing Zhang, Peng Xie, Chengqi Lin, Vincent M. Christoffels, Yueheng Wu, Ping Zhu, Tao P. Zhong

“…Consequently, restoration of PPARGC1A/ESRRA in Hey2- overexpressing zebrafish hearts or human cardiomyocyte-like cells rescues deficits in mitochondrial bioenergetics. Knockdown of Hey2 in adult mouse hearts protects against doxorubicin-induced cardiac dysfunction. …”
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Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC by Domenico Lo Tartaro, Beatrice Aramini, Valentina Masciale, Nikolaos Paschalidis, Francesco Demetrio Lofaro, Anita Neroni, Rebecca Borella, Elena Santacroce, Alin Liviu Ciobanu, Anna Valeria Samarelli, Federica Boraldi, Daniela Quaglino, Alessandra Dubini, Michele Gaudio, Gloria Manzotti, Francesca Reggiani, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Federica Bertolini, Massimo Dominici, Pier Luigi Filosso, Franco Stella, Lara Gibellini, Sara De Biasi, Andrea Cossarizza

“…However, although there is clear evidence for their involvement in cancer immunity, scanty data exist on the characterization of B cell phenotypes, bioenergetic profiles and possible interactions with T cells in the context of NSCLC. …”
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Understanding Muscle Dysfunction in Chronic Fatigue Syndrome by Gina Rutherford, Philip Manning, Julia L. Newton

“…Studies show evidence for skeletal muscle biochemical abnormality in CFS/ME patients, particularly in relation to bioenergetic dysfunction. Discussion. Bioenergetic muscle dysfunction is evident in CFS/ME, with a tendency towards an overutilisation of the lactate dehydrogenase pathway following low-level exercise, in addition to slowed acid clearance after exercise. …”
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A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus by Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S. Chaudhari, Kenneth W. Bayles, Vinai C. Thomas, Rajib Saha

“…ABSTRACT During aerobic growth, S. aureus relies on acetate overflow metabolism, a process where glucose is incompletely oxidized to acetate, for its bioenergetic needs. Acetate is not immediately captured as a carbon source and is excreted as waste by cells. …”
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Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS) by Delfina Larrea, Kirstin A. Tamucci, Khushbu Kabra, Kevin R. Velasco, Taekyung D. Yun, Marta Pera, Jorge Montesinos, Rishi R. Agrawal, Carmen Paradas, John W. Smerdon, Emily R. Lowry, Anna Stepanova, Belem Yoval-Sanchez, Alexander Galkin, Hynek Wichterle, Estela Area-Gomez

“…These findings suggest mitochondria-associated ER membranes (MAM domains) play a crucial role in regulating cellular glucose metabolism and that MAM dysfunction may underlie the bioenergetic deficits observed in ALS.…”
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Engineering artificial photosynthetic life-forms through endosymbiosis by Jay Cournoyer, Sarah D. Altman, Yang-le Gao, Catherine L. Wallace, Dianwen Zhang, Guo-Hsuen Lo, Noah T. Haskin, Angad P. Mehta

“…We engineer various mutants of model photosynthetic cyanobacteria as endosymbionts within yeast cells where, the engineered cyanobacteria perform bioenergetic functions to support the growth of yeast cells under defined photosynthetic conditions. …”
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Morphological and functional decline of the SNc in a model of progressive parkinsonism by Jacob M. Muñoz, John T. Williams, Joseph J. Lebowitz

“…Dendro-dendritic synapses are identified as an early locus of dysfunction in response to bioenergetic decline and suggest that dendritic release sites may contribute to the induction of degeneration.…”
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Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells by D. C. Woods

“…While it has been well established that mitochondria in different tissues have distinctive ultrastructural features consistent with differential bioenergetic demands, recent and emerging technical advances in flow cytometry, imaging, and “-omics”-based bioinformatics have only just begun to explore the complex and divergent properties of mitochondria within tissues and cell types. …”
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Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation by Gianluca Renzi, Ivan Vlassakev, Mattias Hansen, Romane Higos, Simon Lecoutre, Merve Elmastas, Ondrej Hodek, Thomas Moritz, Lynn M. Alaeddine, Scott Frendo–Cumbo, Ingrid Dahlman, Alastair Kerr, Salwan Maqdasy, Niklas Mejhert, Mikael Rydén

“…Overall, our study uncovers a regulatory axis where ER stress drives inflammation in obesity by reducing CKB abundance, and consequently altering the bioenergetic state of the cell.…”
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