Toxicity and antioxidant assessment of ethanol leaf extract of Hibiscus surattensis in Wistar rats: hepatotoxicity evaluation by Israel Kevin Umana, Tobechukwu Anthony Tochukwu, Enoluomen Ehigiator, Chinedu Joseph Ikem, Godswill James Udom, Akinyele Olubiyi Akinsola

“…Results revealed significant rise (p<0.01-0.001) in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), conjugated bilirubin (C.B) and total bilirubin (T.B), as well as in white blood cell (WBC) and platelet at high doses of the extract-treated rats compared to control. …”
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Case Report: Kryptonite—A Rare Case of Left-Sided Bilothorax in a Sickle Cell Patient by Vikas D. Reddy, Anas Al-Khateeb, Muhammad Hussain, Varun Patel, Muqueet Kadri, Rutwik Patel, Siva Prasad Maruboyina, Richard A. Miller, Joseph R. DePasquale

“…The diagnosis is confirmed by a pleural fluid to serum bilirubin ratio of greater than 1. Typically, bilothorax presents as a right-sided effusion due to its proximity to the liver and biliary system. …”
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Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients by Álvaro Urzúa, Carolina Pizarro, Abraham Gajardo, Rafael Poniachik, Claudia Pavez, Máximo Cattaneo, Javier Brahm, Laura Carreño, Jaime Poniachik

“…Fulminant hepatitis, histological cholestasis, alkaline phosphatase, bilirubin, and prothrombin were associated with death/LT.…”
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Granulomatous Hepatitis in Association with Fever and a Palmar Rash by Desmond J Leddin, James A Barrowman

“…While the finding of a disproportionate elevation of alkaline phosphatase relative to serum bilirubin may be a useful pointer towards the diagnosis this pattern is not specific and not consistently observed. …”
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A Multicenter, Prospective Study of a New Fully Covered Expandable Metal Biliary Stent for the Palliative Treatment of Malignant Bile Duct Obstruction by Bret T. Petersen, Michel Kahaleh, Richard A. Kozarek, David Loren, Kapil Gupta, Thomas Kowalski, Martin Freeman, Yang K. Chen, Malcolm S. Branch, Steven Edmundowicz, Michael Gluck, Kenneth Binmoeller, Todd H. Baron, Raj J. Shah, Timothy Kinney, William Ross, Paul Jowell, David Carr-Locke

“…Main outcome measurements included (1) absence of stent occlusion within six months or until death, whichever occurred first and (2) technical success, need for reintervention, bilirubin levels, stent patency, time to stent occlusion, and adverse events. …”
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Biochemical characteristics, genetic variants and treatment outcomes of 55 Chinese cases with neonatal intrahepatic cholestasis caused by citrin deficiency by Juan Li, Jintao Duan, Shuli He, Ying Li, Meifen Wang, Chengjun Deng

“…All NICCD patients were followed up until death or at least 1 year of age.ResultsCompared to INC group, significant increase was found in levels of total bilirubin, indirect bilirubin, total bile acid, gamma-glutamyl transpeptidase, alkaline phosphatase, prothrombin time, thrombin time, international normalized ratio, alpha-fetoprotein (AFP), Vitamin D, and Vitamin E of NICCD group, while alanine aminotransferase, albumin, fibrinogen, glucose, and Vitamin A levels showed significant decrease in the NICCD group (P &lt; 0.05). …”
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The Effects of Different Insufflation Pressures on Liver Functions Assessed with LiMON on Patients Undergoing Laparoscopic Cholecystectomy by H. Barıs Eryılmaz, Dilek Memiş, Atakan Sezer, Mehmet Turan Inal

“…Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin levels were all recorded preoperatively, 1 hour, and postoperative 24 hours after surgery. …”
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Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study by Samar Sultan, Fouzy Lesloom

“…Results Smokers had significantly higher vWF functional activity and hs-cTnI but significantly lower albumin and total bilirubin levels than non-smokers (65.87 ± 19.07 vs 56.45 ± 6.59, respectively, p<0.001; 0.0382 ± 0.0077 vs 0.0147 ± 0.0105, respectively, p<0.001; and 4.63 ± 0.32 vs 4.74 ± 0.28, respectively, p=0.026). …”
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Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers by Mai S. Sater, Nourah Almansour, Zainab Hasan Abdulla Malalla, Salim Fredericks, Muhalab E. Ali, Hayder A. Giha

“…Presepsin, IL-6, and IL-8 discriminated between the SSI sub-types, whilst only presepsin correlated with bilirubin and creatinine. uPAR was positive for kidney dysfunction, and TREM-1 was the only indicator of artificial ventilation (AV). …”
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Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients by Vibha Tandon, Swati Hiwale, Dnyanesh Amle, Tripti Nagaria, Pradeep Kumar Patra

“…The 3 groups are found to be significantly different in terms of RBS (p=0.01), urea (p<0.0001), creatinine (p=0.0005), AST (p=0.0032), ALT (p=0.0007), total protein (p=0.0004), albumin (p<0.0001), calcium (p=0.001), and sodium (p=0.02), while no statistically significant difference was found between total bilirubin (p=0.167), direct bilirubin (p=0.07), uric acid (p=0.16), and potassium (p=0.14). …”
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Ugochukwu, Oliver Ukachi by Maduabuchi , Patrick Aja, Chukwu, Chinecherem Adanna, Okechukwu, Ugwu Paul Chima, Anthony, Boniface Ale, Chinedu , Peter Agu, Deusdedi, Tusubira, Chukwu, Darlington C, Onyedika, Gabriel Ani, Ugbala, Ezebuilo Ekpono, Akobi , Hilary Ogwoni, Awoke , Joshua Nonso, Ogbu, Patience N, Aja, Lucy, Orji, Obasi Uche, Nweke, Chinoso Peter, Egwu, Chinedu, Ekpono, Ejike Ugbala, Ewa, Gift Onyinyechi, Igwenyi, Ikechuku Okorie, Esther, Alum Ugo, Uti, Daniel Ejim, Offor, Christian Emeka, Ifie, Josiah E., Njoku, Amaobichukwu, Kenneth, Ekenechukwu, Ejike, Daniel Eze

“…Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct bilirubin levels were all significantly elevated by BPA (p 0.05). …”
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The Combined Effect of Garlic (Allium sativum) and Turmeric (Curcuma longa) Extracts to Reduce the Adverse Effects of Aflatoxin B1 in Rats by Hadi Sarir, Saeedeh Zakerian, masood didarkhah

“…The use of garlic, turmeric extract, and their combination improves liver function indicators and reduces liver enzymes such as AST, ALT, ALP, and total bilirubin. These results show that the extract of garlic, turmeric, and their combination have a protective effect on the liver. …”
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Validity of the scoring system for traumatic liver injury: a generalized estimating equation analysis by Kangho Lee, Dongyeon Ryu, Hohyun Kim, Chang Ho Jeon, Jae Hun Kim, Chan Yong Park, Seok Ran Yeom

“…Each measure is scored as 0–1 (age and Injury Severity Score) or 0–3 (serum total bilirubin level, prothrombin time, and creatinine level). …”
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Changes in the hematology and blood metabolites of guinea pigs (Cavia porcellus) under intensive rearing system in humid tropical conditions by Daniel Paredes-López, Rizal Robles-Huaynate, Uriel Aldava-Pardave, Miguel Morales-Cauti

“…In serum, profiles of glucose, total protein (TP), albumin, total cholesterol (TC), triglycerides, total bilirubin (TB), and direct bilirubin (DB), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. …”
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Effect of Malaria and Schistosoma mansoni Coinfection on Selected Biochemical Profiles among Patients Attending Selected Health Institutions at Dembiya, Northwest Ethiopia by Wagaw Abebe, Wossenseged Lemma, Yalewayker Tegegne, Amare Mekuanint, Abebe Yenesew, Adane Derso

“…Also, the median values of creatinine, total bilirubin, and direct bilirubin (1.51 mg/dL, 2.35 mg/dL, and 0.91 mg/dL, respectively) in coinfected participants were significantly higher than in the healthy control participants (0.85 mg/dL, 0.42 mg/dL, and 0.12 mg/dL, respectively) p<0.05. …”
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Serum apolipoproiein b-100 concentrations in periparturienl diseases of dairy cows by Turan Civelek, Mutlu Sevinç

“…VLDL. total cholesterol, triglyceride, glucoso (p=0.00l) and total proiem (p=0.003) a;so albumin tp=0 009) levels were significantly decreased, however AST, GGT and total bilirubin (p=0.001 i significantly increased compared lo healthy cows. …”
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Structural Disruption of Cilia and Increased Cytoplasmic Tubulin in Biliary Atresia—An Exploratory Study Focusing on Early Postoperative Prognosis Following Portoenterostomy by Patrícia Quelhas, Rui Oliveira, Carlos Kieling, Sandra Vieira, Jorge dos Santos

“…Reduced cilia length correlated with higher bilirubin levels at portoenterostomy. Predictors of early poor prognosis (death or need for transplantation until 1 year of life) included HIF-1α positivity, elevated direct bilirubin levels, decreased cilia length, PC bending, and increased TUBA4A expression. …”
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Gallbladder Agenesis with Refractory Choledocholithiasis by Jamie Tjaden, Kevin Patel, Aziz Aadam

“…In this case, a 63-year-old female presents with jaundice and episodic right upper quadrant abdominal pain with nausea and vomiting. Bilirubin and alkaline phosphatase were found to be markedly elevated. …”
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A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review by Mian Bilal Alam, Amin Kadoura, Magesh Sathaiah

“…Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative.…”
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Hepatocellular Bile Salt Transport: Lessons from Cholestasis by Michael Trauner, Peter Fickert, Rudolf E Stauber

“…Hepatic uptake and excretion of bile salts and several nonbile salt organic anions (eg, bilirubin) are mediated by a distinct set of polarized transport systems at the basolateral and apical plasma membrane domains of hepatocytes and bile duct epithelial cells (cholangiocytes). …”
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