Progression of ampC amplification during de novo amoxicillin resistance development in E. coli by Luyuan Nong, Martijs Jonker, Wim de Leeuw, Meike T. Wortel, Benno ter Kuile

“…The amoxicillin-resistant ∆ampC did not show amplification of the fragment around the original ampC position but exhibited a large duplication or triplication at another position, suggesting the essential role of the duplicated genes in resistance development.IMPORTANCEAmoxicillin is the most used antimicrobial against bacterial infections. DNA fragments containing ampC are amplified upon prolonged and stepwise increasing exposure to amoxicillin, causing resistance. …”
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In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of R... by M. Elouennass, A. Zohoun, A. El Ameri, N. Alem, J. Kasouati, Y. Benlahlou, I. El Yaagoubi, M. Frikh, A. Lemnouer, A. Benouda

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Prevalence of Hyper virulence and Multidrug resistance Klebsiella pneumoniae isolates from UTI patients by Manar Abdul karim, Zainab Mohammed Alzubaidy, Khazal Dabua Wadi

“… Urinary tract infections (UTIs) are the most common bacterial infections and are often caused by Klebsiella pneumoniae. the results of detection of some virulence factors 30(13.6%)  isolates of K. pneumoniae showed that Hemolysin production was tested using sheep blood agar and it was found that all the 30 (100%) isolates of K. pneumonia not capable to hemolysis red blood. …”
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Dissemination of clinical Escherichia coli harboring the mcr-1 gene in Pakistan by Sabahat Abdullah, Sabahat Abdullah, Muhammad Ahmad Mushtaq, Kalim Ullah, Brekhna Hassan, Mariya Azam, Mariya Azam, Muhammad Asif Zahoor, Juan Wang, Jianzhen Xu, Mark A. Toleman, Mashkoor Mohsin

“…BackgroundColistin is an antibiotic used as a last resort to treat multidrug-resistant Gram-negative bacterial infections. Plasmid-mediated mobile colistin-resistant (mcr) genes in Escherichia coli (E. coli) are disseminated globally and are considered to be a major public health threat. …”
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Parasitic infection prevalence in tuberculosis patients and their household contacts in the Littoral Region of Cameroon by Lucy Cho Nchang, Chefor Magha, Patience Agwa Fonong, Narcisse Victor Tchamatchoua Gandjui, Nancielle Mbiatong Tchatat, Desmond Akumtoh Nkimbeng, Frank Noel Nietcho, Juluis Visnel Foyet, Fanny Fri Fombad, Tatiana Djikeussi Katcho, Jerome Fru Cho, Achim Hoerauf, Manuel Ritter, Samuel Wanji

“…Conclusion: We observed that 31 % of the TB patients and household contacts are infected with parasites including P. falciparum, Loa loa and Since helminths can downregulate immune responses against bacterial infections and thus affect treatment efficacy, we recommend that diagnosis of parasitic infections should be included during TB diagnosis and treatment programmes, especially in rural areas.…”
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Community-based newborn care utilization and associated factors in Nekemte City, Oromia, Ethiopia, 2023 by Dawit Tesfaye Daka, Bizuneh Wakuma, Werku Etafa, Dereje Temesgen Chewaka, Ashenafi Zewdie, Mekdelawit Birhanu Ayele, Yohannis Midekso Beriso, Bruck Tesfaye Legesse, Wandimu Muche Mekonen

“…Despite management improvements, many young infants with serious bacterial infections [PSBI] in resource-limited settings are not receiving recommended inpatient treatment due to accessibility, affordability, or family acceptance issues. …”
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Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat by Krutika R Tandon, Prachi Vani, Rahul Tandon, Nirav Thakar, Swati Kamani, Amit Kumar

“…Aims and background: Most studies related to bacterial infections and their profiles in pediatric patients focus only on the pediatric intensive care unit (PICU) setup. …”
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Enhancing pathogens detection in suspected geriatric bloodstream infections using Nanopore-targeted sequencing by Menghui Zhao, Yan Ouyang, Junchi Mei, Hang Liu

“…The most common bacterial pathogens were Escherichia coli and Staphylococcus aureus (each 7.7%), while Candida albicans was the most prevalent fungal pathogen (30%). Mixed-bacterial infections were detected in 21.7% of NTS-positive cases, and concurrent bacterial–fungal infections were observed in 9.92% of these cases. …”
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Threats of zoonotic pathogens in food chain: Current status and gaps in IndiaKey public health Message: by Madhuchhanda Das, Anup Kumar Ojha, Venencia Albert, Saradi Borah, Thandavarayan Ramamurthy, Samaresh Das, Tapan Kumar Dutta, Hosterson Kylla, Rajkumari Mandakini, Sarangthem Indira Devi

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Vaginal colonization, vertical transmission rate, antimicrobial susceptibility profile, and associated factors of potential neonatal pathogens among pregnant women at public health... by Getnet Shimeles, Getnet Shimeles, Alemu Gedefie, Hilina Motbainor, Chalachew Genet, Chalachew Genet

“…BackgroundVaginal colonization by pathogenic bacteria increases the risk of bacterial infections such as sepsis, which is associated with high neonatal mortality. …”
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Safety of vancomycin-loaded cement spacers for treating gram-positive periprosthetic joint infections in two-stage resection arthroplasty among patients with renal insufficiency by Yu-Chih Lin, Chih-Hsiang Chang, Chih-Chien Hu, Yung-Chieh Liang, Pang-Hsin Hsieh, Sheng-Hsun Lee, Sheng-Hsuan Lin

“…This study hypothesizes that there is no significant correlation between antibiotic levels in blood and synovial fluid and the patient’s kidney function, and that the success rates of staged resection arthroplasty are comparable between groups, specifically targeting gram-positive bacterial infections. Methods This retrospective review included patients treated from 2017 to 2022 with two-stage arthroplasty using vancomycin-loaded ALBC spacers, selectively targeting gram-positive infections. …”
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Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38 by Knut Husø Lauritzen, Knut Husø Lauritzen, Kuan Yang, Michael Frisk, Mieke C. Louwe, Maria Belland Olsen, Maria Belland Olsen, Mathias Ziegler, William E. Louch, Bente Halvorsen, Bente Halvorsen, Pål Aukrust, Pål Aukrust, Arne Yndestad, Øystein Sandanger, Øystein Sandanger

“…Mice lacking CD38 are very susceptible to acute bacterial infections, implicating CD38 in innate immune responses. …”
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mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae by Ting Huang, Siyou Che, Zheng Lv, Danrui Hao, Runyu Wang, Qinxuan Yi, Ling Mei, Yang Yuan, Hang Zou, Yidong Guo, Xinrong Wang, Yiwen Chu, Kelei Zhao

“…To date, messenger RNA (mRNA) vaccine is one of the most advancing technologies and are extensively investigated for viral infection, while infrequently applied for prevention of bacterial infections. In the present study, we aim to construct a new mRNA vaccine encoding YidR or combining with a tissue plasminogen activator signal sequence for preventing K. pneumoniae infection. …”
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Clinical Features of COVID‐19 Associated Pulmonary Aspergillosis: A Multicenter, Retrospective Study by Yasheng Zhan, Guojun He, Cheng Zhong, Yake Yao, Jiangying Zhou, Tong Li, Hua Zhou

“…In addition, all patients suffered bacterial infections and received antibacterial agents before CAPA, with an average duration of 22.6 days. …”
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Pengaruh Pemberian Glutamin pada Kemampuan Fagositosis Makrofag terhadap Pseudomonas Aeruginosa by Daslina , Eryati Darwin, Aziz Djamal

“…<br />Kata kunci: glutamin, fagositosis makrofag, Pseudomonas aeruginosa</p><p> </p><p>Abstract <br />Pseudomonas aeruginosa is the most common cause of bacterial infections that are resistant to antibiotics. Glutamine is an amino acid  in the body that able to modulate the body's immune function. …”
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Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study by Charlotte Boullé, Elodie Lebredonchel, Jérémy T. Campillo, Valentin Dupasquier, Marlhand C. Hemilembolo, Sébastien D. S. Pion, Jean Claude Djontu, Ludovic Rancé, Philippe Souteyrand, François Missamou, Michel Boussinesq, Francine Ntoumi, Cédric B. Chesnais

“…It demonstrates a strong association between L. loa MFD and reduced SV, suggesting that loiasis may lead to AH, and potentially to functional hyposplenia, with consequences such as increased susceptibility to bacterial infections. Malaria was associated with splenomegaly, with a figure of HMS consistent with estimates from other African countries. …”
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Analysis of Role of Haematological Parameters in Diagnosis of Grampositive and Gram-negative Urinary Tract Infection: A Case-control Study by Sudha Srinivasan, Ayeesha Sithika Thajudeen, Kundhavai Chandrasekaran, Vijayashree Raghavan, D Roshini

“…Introduction: Urinary Tract Infections (UTIs) are a prevalent global health issue, primarily caused by bacterial infections. Early diagnosis and intervention are critical to preventing complications like pyelonephritis and mitigating the risk of recurrent infections that can lead to permanent scarring. …”
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Exploring the clinical value of procalcitonin, c-reactive protein, white blood cell count, and neutrophil-to-lymphocyte ratio in the early diagnosis of bloodstream infections in ch... by Yadong Li, Mingjie Li, Chenye Lin, Wentao Tang, Qiuyu Tang, Feng Cheng

“…Elevated levels of PCT and CRP were often associated with fungal or G- bacterial infections, with PCT showing particularly significant effects. …”
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Selection of potential probiotic candidate bacteria from seawater and shrimp pond sediments for controlling the pathogenic Vibrio parahaemolyticus by Anisa Zulfani, Munti Yuhana, Sukenda Sukenda, Usamah Afif

“…The environmentally friendly approach to prevent bacterial infections in shrimp is through the application of probiotics. …”
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Genome analysis of colistin-resistant Salmonella isolates from human sources in Guizhou of southwestern China, 2019–2023 by Jingtong Wu, Yongxian Wen, Lv You, Xiaoyu Wei, Xiaoyu Wei, Junhua Wang, Ge Zhu, Shijun Li

“…BackgroundColistin is commonly used as a last-resort antibiotic for multidrug resistance (MDR) bacterial infections. The emergence of colistin-resistant (CL-R) Salmonella has become a significant public health concern. …”
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