Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons by Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur

“…Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. …”
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Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing by Barbara Imbrosci, Angela Neitz, Thomas Mittmann

“…Despite this well accepted notion, recent research has shown that, under certain circumstances, the axon can also generate APs independent of synaptic inputs at axonal sites distal from the soma. …”
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Peripheral Nerve Regeneration with Acellular Nerve Allografts Seeded with Amniotic Fluid-Derived Stem Cells by Xue Ma, Eileen Elsner, Jiaozhong Cai, Thomas L. Smith, Zhongyu Li

“…Tissue engineering strategies have attempted to mimic regenerating axons’ environment by adding supportive types of cells other than Schwann cell to the nerve allograft. …”
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Reduced Fascicle Area Demonstrated in Ilioinguinal Nerves Resected from Primary Inguinal Herniorrhaphy Patients as Evidence of Compression Neuropathy by Robert Wright, Donald E. Born, Troy Sanders, Jordan Landes, Troy Salisbury, Anjali S. Kumar, Makena Horne

“…Further studies with larger samples are needed to confirm the observed effect of nerve location on the total nerve cross-sectional area and axon loss.…”
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Biomaterial-based strategies: a new era in spinal cord injury treatment by Shihong Zhu, Sijun Diao, Xiaoyin Liu, Zhujun Zhang, Fujun Liu, Wei Chen, Xiyue Lu, Huiyang Luo, Xu Cheng, Qiang Liao, Zhongyu Li, Jing Chen

“…Additionally, these scaffolds should facilitate axon growth and neurogenesis by offering adjustable topography and a range of physical and biochemical cues. …”
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Medial and lateral vestibulospinal projections to the cervical spinal cord of the squirrel monkey by Richard Boyle

“…The innervation pattern of iMVST axons resembled that of VOC and cMVST axons but was less extensive and supplied mostly the upper two cervical segments. …”
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Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells by Sasi Kumar Jagadeesan, Ahmad Galuta, Ryan Vimukthi Sandarage, Eve Chung Tsai

“…Enrichment of pathways related to neurogenesis, axon guidance, and synaptic signaling varied across donors, highlighting the impact of genetic and epigenetic individuality on NSPC behavior.…”
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Hodological patterning as an organizing principle in vertebrate motor circuitry by Joel C. Glover

“…Hodological patterning refers to developmental mechanisms that link the location of neurons in the brain or spinal cord to specific axonal trajectories that direct connectivity to synaptic targets either within the central nervous system or in the periphery. …”
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Neuroprotective and Neurorestorative Processes after Spinal Cord Injury: The Case of the Bulbospinal Respiratory Neurons by Anne Kastner, Valéry Matarazzo

“…Since part of this recovery is dependent on the damaged side of the spinal cord, the present review highlights our current understanding of the anatomical neuroplasticity processes that are developed by the surviving damaged bulbospinal neurons, notably axonal sprouting and rerouting. Such anatomical neuroplasticity relies also on coordinated molecular mechanisms at the level of the axotomized bulbospinal neurons that will promote both neuroprotection and axon growth.…”
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Comprehensive pan-cancer analysis reveals NTN1 as an immune infiltrate risk factor and its potential prognostic value in SKCM by Fuxiang Luan, Yuying Cui, Ruizhe Huang, Zhuojie Yang, Shishi Qiao

“…Abstract Netrin-1 (NTN1) is a laminin-related secreted protein involved in axon guidance and cell migration. Previous research has established a significant connection between NTN1 and nervous system development. …”
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Multifaceted roles of ninjurin1 in immunity, cell death, and disease by Lili Zhu, Yunfei Xu, Yunfei Xu

“…Ninjurin1 (NINJ1) is initially identified as a nerve injury-induced adhesion molecule that facilitates axon growth. It is initially characterized to promote nerve regeneration and mediate the transendothelial transport of monocytes/macrophages associated with neuroinflammation. …”
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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease by Emma V. Jones, David S. Bouvier

“…These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. …”
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The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis by Khalil S. Rawji, V. Wee Yong

“…Many studies, however, have also reported beneficial roles of macrophages/microglia, including axon regenerative roles, assistance in promoting remyelination, clearance of inhibitory myelin debris, and the release of neurotrophic factors. …”
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Case report: Guillain-Barré syndrome and possible association with Lyme disease by I. Muliuolis, E. Tilindytė, R. Samaitienė

“… Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating or axon-damaging polyneuropathy. It is characterized by sensory, motor and reflex disorder, damaged cranial nerves, autonomic disorders, and, less frequently, damage to the central nervous system. …”
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Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells by Junhao Deng, Yiling Zhang, Yong Xie, Licheng Zhang, Peifu Tang

“…Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well. …”
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Differentially Expressed microRNAs in Peritoneal Dialysis Effluent-Derived Exosomes from the Patients with Ultrafiltration Failure by Weifei Wu, Xu Wu, Zhiqun Cheng, Zhenzhen Yang, Minhui Lu, Jing Cheng

“…Functional analyses revealed that these DE-miRNAs were significantly enriched in pathways of cancer, ubiquitin-mediated proteolysis, axon orientation, and the Rap1 and Ras signaling pathways. …”
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Age-Related Decrease in the Schaffer Collateral-Evoked EPSP in Awake, Freely, Behaving Rats by C. A. Barnes, G. Rao, G. Orr

“…These electrophysiological findings are consistent with the hypothesis that old rats have fewer functional synaptic contacts per Schaffer collateral axon than do young rats. The possibility that this age change arises as a result of a differential tissue recovery response to in vitro preparation was examined in the present study. …”
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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…The result is a loss of neuronal homeostasis and progressive die-back of motor axons culminating in death of the afflicted motor neurons. …”
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Synthesis of Functional Polyester Based on Polylactic Acid and Its Effect on PC12 Cells after Coupling with Small Peptides by Na Qiang, Shuo Tang, Xiang Liao, Hao Liang, Fang Xie, Ji-xiang Zhu

“…The small peptide was beneficial to the axon growth of PC12 cells.…”
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Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies by Alexandra D. Medyanik, Polina E. Anisimova, Angelina O. Kustova, Victor S. Tarabykin, Elena V. Kondakova

“…Although channelopathies indeed make up a significant proportion of DEE cases, many other mechanisms have been identified: impaired neurogenesis, metabolic disorders, disruption of dendrite and axon growth, maintenance and synapse formation abnormalities —synaptopathies. …”
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