Measuring Hemoglobin Levels in the Optic Disc of Parkinson’s Disease Patients Using New Colorimetric Analysis Software by Maria Pilar Bambo, Elena Garcia-Martin, Maria Satue, Susana Perez-Olivan, Silvia Alayon, Marta Gonzalez-Hernandez, Vicente Polo, Jose Manuel Larrosa, Manuel Gonzalez-De la Rosa

“…Measurements of optic disc Hb levels obtained with the Laguna ONhE software had good ability to detect optic nerve color changes (more papillary paleness and consequently this could suggest optic atrophy and axonal loss) in PD patients.…”
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Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain by Zhangyu Ma, Qianqian Wan, Wenpin Qin, Wen Qin, Janfei Yan, Yina Zhu, Yuzhu Wang, Yuxuan Ma, Meichen Wan, Xiaoxiao Han, Haoyan Zhao, Yuxuan Hou, Franklin R. Tay, Lina Niu, Kai Jiao

“…In vitro experiments also confirmed that norepinephrine released by sympathetic neurons promotes the activation and axonal growth of sensory neurons. Moreover, we also discovered that through releasing norepinephrine, regional sympathetic nerves of subchondral bone were found to regulate growth and activation of local sensory nerves synergistically with other pain regulators. …”
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Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury by Chenxi Zhang, Shujie Zhao, Zhenfei Huang, Ao Xue, Hao Liu, Siming Dai, Ziyang Zheng, Yin Li, Xiaodong Guo, Jun Gu, Feng Zhang, Fubing Wang, Yongxiang Wang, Xiaohua Zhou, Shujun Zhang, Hanwen Zhang, Jun Shen, Jian Chen, Guoyong Yin

“…Inhibition of macropinocytosis might reverse this effect, resulting in enhanced axonal regeneration and reduced neural apoptosis, thereby improving outcomes after SCI. …”
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IgD Multiple Myeloma Paraproteinemia as a Cause of Myositis by I. Colombo, M. E. Fruguglietti, L. Napoli, M. Sciacco, E. Tagliaferri, A. Della Volpe, V. Crugnola, N. Bresolin, M. Moggio, A. Prelle

“…Sural nerve biopsy demonstrated both demyelinating and axonal aspects with no inflammatory infiltrates, but positivity for HLA and MAC. …”
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Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans by Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang

“…Neuron guidance factor Semaphorin 3A (Sema3A) is a membrane-associated secreted protein with chemorepulsive properties for axons. However, the role of Sema3A in articular cartilage is still not clear. …”
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High-Dose Neural Stem/Progenitor Cell Transplantation Increases Engraftment and Neuronal Distribution and Promotes Functional Recovery in Rats after Acutely Severe Spinal Cord Inju... by Taoyang Yuan, Qian Liu, Jie Kang, Hua Gao, Songbai Gui

“…However, the dose-related effects of the neural stem/precursor cell (NSPC) transplantation on the injury microenvironment, NSPC survival, axonal growth, neuronal distribution, the composition of neurons, oligodendrocytes, and astrocytes in the lesion area and functional recovery have not yet been quantitatively evaluated in the context of severe SCI. …”
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Microglia Play a Major Role in Direct Viral-Induced Demyelination by Dhriti Chatterjee, Kaushiki Biswas, Soma Nag, S. G. Ramachandra, Jayasri Das Sarma

“…Previous studies demonstrated that microglia can be persistently infected by neurotropic mouse hepatitis virus (MHV) which causes meningoencephalitis, myelitis with subsequent axonal loss, and demyelination and serve as a virus-induced model of human neurological disease multiple sclerosis (MS). …”
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Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies by Oliver C. Kiersnowski, Pietro Mattioli, Lucia Argenti, Laura Avanzino, Francesco Calizzano, Andrea Diociasi, Laura Falcitano, Chunlei Liu, Mattia Losa, Federico Massa, Silvia Morbelli, Beatrice Orso, Elisa Pelosin, Stefano Raffa, Matteo Pardini, Dario Arnaldi, Luca Roccatagliata, Mauro Costagli

“…SBR Z-scores in the putamen correlated with increased PCS in the substantia nigra and reduced |DCS| in the putamen, which may reflect dopaminergic degeneration ascribable to iron accumulation and nigrostriatal neuron axonal loss, respectively.…”
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Fever, Myositis, and Paralysis: Is This Inflammatory Myopathy or Neuroinvasive Disease? by Aneeta R. Kiran, Richard A. Lau, Kim M. Wu, Andrew L. Wong, Philip J. Clements, Emil R. Heinze

“…EMG/NCS showed sensorimotor axonal polyneuropathy and the cerebrospinal fluid was positive for IgM and IgG WNV antibodies. …”
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Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model by Wook Jeong, Hsichiang Kung, Chia Chi Cheng, Changwoo Lim, Min Jung Jung, Jaeho Lee, Doo Sik Kim, Yusom Shin

“…The gross findings with H&E staining showed that the number of axons was higher in group 3 than in group 2. There was no histological difference according to the DXM concentration. …”
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Quality of Life in Painful Peripheral Neuropathies: A Systematic Review by Ayesha Girach, Thomas Henry Julian, Giustino Varrassi, Antonella Paladini, Athina Vadalouka, Panagiotis Zis

“…Other aetiologies of painful PN where QoL has been studied to date include gluten, immune-mediated, HIV, chemotherapy-induced, and chronic idiopathic axonal polyneuropathy. Pharmacological treatment is the mainstay in managing pain and has a direct positive and independent effect on the overall QoL. …”
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Methimazole Inhibits the Expression of GFAP and the Migration of Astrocyte in Scratched Wound Model In Vitro by Lina Zhao, Xianyu Zhang, Chunhai Zhang

“…Therefore, slowing the astrocytic activation process may give a time window of axonal growth after the CNS injury. However, the underlying mechanism of astrocytic activation remains unclear, and there is no effective therapeutic strategy to attenuate the activation process. …”
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Cerebral organoids: a promising model in cellular technologies by T. A. Shnaider

“…Generation of hybrid three-dimensional cerebral organoids with different brain region identity allows remodeling some of them, including long-distance neuronal migration or formation of major axonal tracts. In this review, we consider the technology of obtaining human pluripotent stem cell-derived three-dimensional cerebral organoids with different modifications and with different brain region identity. …”
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Coexistence of Factor VII Deficiency and Hereditary Spastic Paraplegia in Two Siblings by Hortensia De la Corte-Rodriguez, E. Carlos Rodriguez-Merchan, M. Teresa Alvarez-Roman, Ana L. Hernandez-Moreno

“…Findings from the tests confirmed the diagnosis of HSP (axonal degeneration of the central motor pathway and pyramidal tracts), further complicated by mixed neuropathy. …”
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The effects of secretome of umbilical cord mesenchymal stem cells on regeneration of sciatic nerve defects in Sprague dawley rats. by Aryadi Kurniawan, Ismail Hadisoebroto Dilogo, Jeanne Adiwinata Pawitan, Wahyu Widodo, Ihsan Oesman, Ade Martinus

“…The highest number of myelinated axons was found in group 1 and 3, namely 175.1 ± 15.9 and 168.9 ± 11.7 (p <0.001). …”
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Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells by Vedavathi Madhu, Abhijit S. Dighe, Quanjun Cui, D. Nicole Deal

“…Additionally, in vitro subcutaneous implants of SB431542 and dorsomorphin treated hADSCs displayed significantly higher expression of active-axonal-growth-specific marker GAP43. Our data offers novel insights into cell-based therapies for the nervous system repair.…”
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A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts by Jessica Wiseman, Raja Haseeb Basit, Akihiro Suto, Sagnik Middya, Bushra Kabiri, Michael Evans, Vinoj George, Christopher Adams, George Malliaras, Divya Maitreyi Chari

“…Critically, we observed hallmark pathological responses in injury foci including cell scarring, immune cell infiltration, precursor cell migration, and short-range axonal sprouting. Delivering test magnetic particles to evaluate the potential of the model for biomaterial screening shows a high uptake of introduced magnetic particles by injury-activated immune cells, mimicking in vivo findings. …”
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Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for... by Eun Hee Ahn, Jae-Bong Park

“…This instability in microtubules damages axons and dendrites, resulting in neuronal impairment. …”
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The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients by Zeynep Tuncer, Gamze Dereli Can, Hava Dönmez Keklikoğlu, Fatma Ayşen Eren, Fatma Yülek, Orhan Deniz

“…Visual dysfunction in PD cannot be attributed only to retinal pathology; however, the retina may provide monitoring of the status of dopaminergic neurodegeneration and axonal loss in PD.…”
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Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo by Peter J. Gagolewicz, Hans C. Dringenberg

“…The rodent primary visual cortex (V1) is densely innervated by serotonergic axons and previous in vitro work has shown that serotonin (5-HT) can modulate plasticity (e.g., long-term potentiation (LTP)) at V1 synapses. …”
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