Alveolar Hemorrhage, a Rare and Life-Threatening Complication of Catastrophic Antiphospholipid Syndrome by Grace Loza, Carlos Hallo, Byron Chiliquinga, Alejandro Hallo

“…This life-threatening complication results from autoimmune damage to the alveolar blood vessels. Given the limited literature addressing the association of these two pathologies, we report a series of three cases with this complication and then compare our findings with 6 cases reported in the literature.…”
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Cytokine Storm Syndrome Responsive to IL-1 Inhibition in Trisomy 21 by Aimee Magnarelli, Julia Shalen, Maria J. Gutierrez

“…Extensive investigations ruled out infections, autoimmune conditions, malignancies, and inborn errors of immunity as triggers for a CSS. …”
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Role of myositis-specific autoantibodies in personalized therapy by Anand N Malaviya, Sanjiv Kapoor

“…It is becoming clear that the increasing numbers of autoantibodies being discovered may necessitate a name change to “autoimmune myositis” (AIM), as recently suggested by a French-Canadian group. …”
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Unilateral Anterior Scleritis Following the Booster Shot of Inactivated COVID-19 (Sinopharm) Vaccine in a 52-Year-Old Woman: A Case Report by Kimia Jazi, Mahnaz Rahimi, Fatemeh Hasani, Maryam Shirmohammadi, Maryam Masoumi

“…Very few vaccination-related adverse events may manifest an unrecognized underlying autoimmune vasculopathy which may also require urgent management. …”
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Inflammatory Chemokine Expression via Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells by Hiroshi Tanaka, Tadaatsu Imaizumi

“…The activation of TLRs and their downstream immune responses can be induced by both infectious pathogens and noninfectious stimuli such as endogenous ligands, and this mechanism may be involved in the pathogenesis of autoimmune renal diseases. However, there are few data on the interaction between TLR3, MDA5, and RIG-I in autoimmune glomerular diseases. …”
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A Curious Case of Hemolytic Anemia with Pseudoreticulopenia by Scott Mayer, Nikhilesh Srinivasan, Jenny Nguyen, Ryan Spilman, Dmitriy Scherbak

“…Herein, we present a unique case of a Coombs-negative, steroid-refractory autoimmune hemolytic anemia (AIHA) complicated by pseudoreticulopenia, describe its clinical presentation, histopathologic findings, and management, and review the salient literature. …”
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Effect of Humulus lupulus L. (Hop) on Postmenopausal Sexual Dysfunction: A Randomized Clinical Trial by Zahra Vahedpoorfard, Samira Ferdosi, Habibollah Rahimi, Hossein Motedayyen

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Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition? by Jean-François Viallard, Marie Parrens, Frédéric Rieux-Laucat

“…The heterozygous mutation in the FASL gene, not present in the Genome Aggregation Database or ClinVar database, could suggest atypical Autoimmune LymphoProliferative Syndrome and its role in this patient’s immunodepression is discussed. …”
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Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis by Agnieszka Starzyk, Piotr Charzewski

“… Introduction: Hashimoto's Thyroiditis (HT) is a common autoimmune thyroid disorder caused by genetic predispositions and environmental factors, such as iodine imbalance, selenium deficiency, and stress. …”
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A Novel Insight into the Role of PLA2R and THSD7A in Membranous Nephropathy by Pingna Zhang, Weijun Huang, Qiyan Zheng, Jingyi Tang, Zhaocheng Dong, Yuhua Jiang, Yuning Liu, Weijing Liu

“…Membranous nephropathy (MN) is an organ-restricted autoimmune disease mainly caused by circulating autoantibodies against podocyte antigens, including the M-type phospholipase A2 receptor (PLA2R) and thrombospondin domain-containing 7A (THSD7A). …”
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TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease by Menghao Zhang, Na Kang, Xin Yu, Xiaoyang Zhang, Qinghui Duan, Xianqiang Ma, Qiancheng Zhao, Zhimian Wang, Xiao’ou Wang, Yeling Liu, Yuxiao Zhang, Can Zhu, Ruiyu Gao, Xin Min, Cuifeng Li, Jin Jin, Qian Cao, Rongbei Liu, Xiaoyin Bai, Hong Yang, Lidan Zhao, Jinjing Liu, Hua Chen, Yonghui Zhang, Wanli Liu, Wenjie Zheng

“…Abstract TNF inhibitors have been used to treat autoimmune and autoinflammatory diseases. Here we report an unexpected mechanism underlying the therapeutic effects of TNF inhibitors in Behçet’s disease (BD), an autoimmune inflammatory disorder. …”
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Expression of the JAK/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis by K. Juczynska, A. Wozniacka, E. Waszczykowska, M. Danilewicz, M. Wagrowska-Danilewicz, J. Wieczfinska, R. Pawliczak, A. Zebrowska

“…Irregular functioning of the cascade may contribute to pathogenesis of autoimmune diseases; however, there are no reports concerning autoimmune bullous diseases yet to be published. …”
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Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis by Aleksandar Arsenijevic, C. Randall Harrell, Crissy Fellabaum, Vladislav Volarevic

“…Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by the progressive destruction of small- and medium-sized intrahepatic bile ducts with resultant cholestasis and progressive fibrosis. …”
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Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis by Fan Yang, Beibei Ni, Xiaoqi Liang, Yizhan He, Chao Yuan, Jiajie Chu, Yiju Huang, Hongyu Zhong, Li Yang, Jianxi Lu, Yan Xu, Qi Zhang, Wenjie Chen

“…However, their effects on autoimmune hepatitis (AIH) are not yet well understood. …”
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Bibliometric analysis of metformin as an immunomodulator (2013–2024) by Tongyi Zhou, Yunfeng Yu, Liu Li, Xiu Liu, Xiu Liu, Qin Xiang, Rong Yu, Rong Yu

“…Recent research has highlighted metformin’s application in aging, autoimmune diseases, COVID-19, and tuberculosis. Additionally, its role in regulating inflammation and gut microbiota is also being investigated.ConclusionOverall, the immunomodulatory effects of metformin were investigated in anti-tumor, antiviral, anti-aging, and autoimmune disease research. …”
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Lenalidomide-Associated ITP by Christina I. Herold, Cristina Gasparetto, Gowthami M. Arepally

“…However, the immunomodulatory properties of lenalidomide may give rise to unexpected autoimmune complications. Herein, we describe a case of immune thrombocytopenic purpura (ITP) associated with use of lenalidomide.…”
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Interstitial Nephritis in a Patient with Inflammatory Bowel Disease by Payaswini Vasanth, Michelle Parmley, Jose Torrealba, Tamim Hamdi

“…Various aspects of this theory have been challenged with a potential role for the underlying autoimmune disorder. Steroids are the mainstay of treatment and mycophenolate mofetil might be an effective alternative. …”
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Identifying effective immune biomarkers in alopecia areata diagnosis based on machine learning methods by Qingde Zhou, Lan Lan, Wei Wang, Xinchang Xu

“…Abstract Background Alopecia areata (AA) is a common non-scarring hair loss disorder associated with autoimmune conditions. However, the pathobiology of AA is not well understood, and there is no targeted therapy available for AA.  …”
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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

“…Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn’s disease. …”
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Variations in Rodent Models of Type 1 Diabetes: Islet Morphology by Lesya Novikova, Irina V. Smirnova, Sonia Rawal, Abby L. Dotson, Stephen H. Benedict, Lisa Stehno-Bittel

“…This study focused on 1 toxin-induced and 2 autoimmune rodent models of T1D: BioBreeding Diabetes Resistant rats, nonobese diabetic mice, and Dark Agouti rats treated with streptozotocin. …”
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