Radiological Patterns of Lung Involvement in Inflammatory Bowel Disease by Diletta Cozzi, Chiara Moroni, Gloria Addeo, Ginevra Danti, Monica Marina Lanzetta, Edoardo Cavigli, Massimo Falchini, Fabio Marra, Claudia Lucia Piccolo, Luca Brunese, Vittorio Miele

“…The common embryonic origin of intestine and lungs from the foregut, autoimmunity, smoking, and bacterial translocation from the colon may all be involved in the pathogenesis of these manifestations in IBD patients. …”
Get full text

Pulmonary Complications of Monogenic Patients with Common Variable Immunodeficiency: COVID-19 Perspectives by Samaneh Delavari, Marzie Esmaeili, Fereshte Salami, Seyed Erfan Rasouli, Saba Fekrvand, Mahsa Yousefpour Marzbali, Nazanin Fathi, Hassan Abolhassani

“…Monogenic forms of CVID have a distinct pattern in different infectious and non-infectious pulmonary manifestations including autoimmunity, atopy, lymphoproliferation, and cancer.…”
Get full text

Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications by Ahmad Vafaeian, Fateme Rajabi, Nima Rezaei

Get full text

Establishment Methods and Application Evaluation of Animal Models in Reproductive Toxicology Research by HUANG Dongyan, WU Jianhui

“…This paper summarizes commonly used animal models for reproductive and development toxicity evaluation in reproductive toxicology research, including rat models for fertility and early embryonic development toxicity, rat models for embryo-fetal development toxicity, rabbit models for embryo-fetal development toxicity evaluation, minipig models for embryo-fetal development toxicity, rat models for perinatal toxicity, zebrafish models for embryonic development toxicity, and models for evaluating ovarian toxicity induced by chemical drugs, radiotherapy, autoimmunity, and ovariectomy, as well as models for evaluating testicular toxicity caused by chemical drugs and environmental factors. …”
Get full text

Development and Evaluation of an In-House ELISA to Detect Anti-FcεR1α IgG Autoantibodies in Chronic Spontaneous Urticaria Patients by Chattip Sripatumtong, Tunsuda Tansit, Papapit Tuchinda, Duangjit Kanistanon, Kanokvalai Kulthanan, Yuttana Srinoulprasert

“…Association between chronic spontaneous urticaria (CSU) and autoimmunity has been well documented. Autologous serum skin testing could support the autoimmune etiology of CSU, whereas it is difficult to interpret and could not be performed on antihistamine omitted patients. …”
Get full text

Large-Scale Screening in General Population Children for Celiac Disease with a Multiplex Electrochemiluminescence (ECL) Assay by Ling He, Xiaofan Jia, Yong Gu, Dongmei Miao, Kathleen Waugh, Cristy Geno, Edwin Liu, Marian Rewers, Liping Yu

“…Background. Autoimmunity Screening for Kids (ASK) study was launched to screen general population children for type 1 diabetes (T1D) and celiac disease (CD). …”
Get full text

The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes by Vedran Premužić, Ivan Padjen, Mislav Cerovec, Marijana Ćorić, Bojan Jelaković, Branimir Anić

“…Discontinuation of anti-TNF-alpha therapy and initiation of immunosuppressive therapy led to improvement in serologic abnormalities and renal function in two patients, while the third patient’s 24-hour proteinuria was only partially reduced, which supports previous reports on TNF-alpha inhibitor induced autoimmunity. Two of our patients had previously been diagnosed with type 2 diabetes mellitus while the third patient developed diabetes years after the onset of IgAN. …”
Get full text

Why is it so difficult to understand why we don’t understand human systemic lupus erythematosus? Contemplating facts, conflicts, and impact of “the causality cascade paradigm”... by Ole Petter Rekvig, Ole Petter Rekvig

“…Classification criteria, autoimmunity, DNA structures, and anti-dsDNA antibodies are integrated aspects in this discussion.…”
Get full text

New Insights on Childhood Lupus Nephritis by Marchi-Silva R, De Aquino BM, Londe AC, Mazzola TN, Julio PR, Wampler Muskardin T, Appenzeller S

“…Rodrigo Marchi-Silva,1,2 Bruna Martins De Aquino,1,2 Ana Carolina Londe,1,2 Ta&iacgr;s Nitsch Mazzola,3 Paulo Rogério Julio,4 Theresa Wampler Muskardin,5,6 Simone Appenzeller2,7 1Medical Pathophysiology Graduate Program, School of Medical Science, Universidade Estadual de Campinas, Campinas, Brazil; 2Autoimmunity Lab, School of Medical Science, Universidade Estadual de Campinas, Campinas, Brazil; 3Center for Molecular Biology and Genetic Engineering (CBMEG), Universidade Estadual de Campinas, Campinas, Brazil; 4Child and Adolescent Graduate Program, School of Medical Science, Universidade Estadual de Campinas, Campinas, Brazil; 5Hospital of Special Surgery, Department of Medicine, New York, NY, USA; 6Weill Cornell Medicine, Department of Medicine and Department of Pediatrics, New York, NY, USA; 7Department of Orthopedics, Rheumatology and Traumatology, School of Medical Science, Universidade Estadual de Campinas, Campinas, BrazilCorrespondence: Simone Appenzeller, Faculdade de Ciências Médicas (FCM)/Hospital de Clínicas (HC) – UNICAMP, Vital Brasil Street, 251, Campinas, SP, 13083-888, Brazil, Tel +55 11 98887-8693, Email appenzel@unicamp.brAbstract: Approximately one in five patients with systemic lupus erythematosus (SLE) has disease-onset during childhood (cSLE). …”
Get full text

Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies by Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Aleksandra Klimowicz, Michał Kloska, Dorota Mańkowska-Wierzbicka, Jerzy Sowiński, Marek Ruchała

“…The autoimmune study group (AIT) consisted of 39 patients newly diagnosed with hypothyroidism in a course of chronic autoimmune thyroiditis. …”
Get full text

lncRNA IGHCγ1 Acts as a ceRNA to Regulate Macrophage Inflammation via the miR-6891-3p/TLR4 Axis in Osteoarthritis by Pengjun Zhang, Jianmei Sun, Caihong Liang, Bingjie Gu, Yang Xu, Hongying Lu, Bo Cao, Hao Xu

“…Accumulating data have implicated that long noncoding RNA (lncRNA) plays an important role in osteoarthritis (OA), which may function as a competitive endogenous RNA (ceRNA) of microRNAs (miRNAs). lncRNA IGHCγ1 has been demonstrated to regulate inflammation and autoimmunity. Nonetheless, the altering effect of IGHCγ1 in OA remains unclear. …”
Get full text

Graves’ disease diagnosed nearly six months after microwave ablation of benign thyroid nodules: a case report by Yunru Gu, Rui Chen, Mingming Chen, Xiaohong Jiang, Long Wang, Xiaolin Huang

“…Conclusions In this case, we presented the onset of Graves’ disease following microwave ablation in a patient with subclinical thyroid autoimmunity. While the causal relationship between microwave ablation and Graves’ disease remains unproven, this case suggests that preexisting autoimmune thyroid conditions may increase susceptibility to postoperative thyroid dysfunction. …”
Get full text

Towards a Vaccine Against Rheumatic Fever by L. Guilherme, K. C. Faé, F. Higa, L. Chaves, S. E. Oshiro, S. Freschi de Barros, C. Puschel, M. A. Juliano, A. C. Tanaka, G. Spina, J. Kalil

“…Rheumatic fever (RF) is an autoimmune disease which affects more than 20 million children in developing countries. …”
Get full text

The identification of a SARs-CoV2 S2 protein derived peptide with super-antigen-like stimulatory properties on T-cells by Thai Hien Tu, Fatima Ezzahra Bennani, Nasser Masroori, Chen Liu, Atena Nemati, Nicholas Rozza, Amichai Meir Grunbaum, Richard Kremer, Catalin Milhalcioiu, Denis-Claude Roy, Christopher E. Rudd

“…While the clinical significance of P3 in COVID-19 remains unclear, its homology to other mammalian proteins suggests a potential role for this peptide family in human inflammation and autoimmunity.…”
Get full text

B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies by Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Ziliang Ao, Mark Meloche, C. Bruce Verchere, Lieping Chen, Dawei Ou, Alice Mui, Garth L. Warnock

“…The two main obstacles after islet transplantation are alloreactive T-cell-mediated graft rejection and recurrence of autoimmune diabetes mellitus in recipients. T cells play a central role in determining the outcome of both autoimmune responses and allograft survival. …”
Get full text

Inborn Errors of Immunity Presenting with Early-Onset Severe Atopy by Nipat Chuleerarux, Nadia Makkoukdji, Travis Satnarine, Jessica Elise Kuhn, Tanawin Nopsopon, Peerada Valyasevi, Fernanda Bellodi Schmidt, Gary Kleiner, Melissa Gans

“…Additionally, we discuss the importance of recognizing such severe atopy as a potential indicator of an underlying immune deficiency, particularly when accompanied by unusual infections, growth failure, or autoimmunity. This review aims to raise awareness of this association and emphasize the need for early diagnosis and genetic testing in patients with atypical or treatment-resistant allergic diseases, allowing for more timely diagnosis of underlying immunodeficiencies and appropriate treatments.…”
Get full text

In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity by Gianandrea Guidetti, Alessandro Di Cerbo, Angela Giovazzino, Valentina Rubino, Anna Teresa Palatucci, Sara Centenaro, Elena Fraccaroli, Laura Cortese, Maria Grazia Bonomo, Giuseppina Ruggiero, Sergio Canello, Giuseppe Terrazzano

“…Several extrinsic factors, like drugs and chemicals, can foster autoimmunity. Tetracyclines, in particular oxytetracycline (OTC), appear to correlate with the emergence of immune-mediated diseases. …”
Get full text

Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome by Jingyi Xu, Shucheng Si, Yijun Han, Lin Zeng, Jinxia Zhao

“…Abstract Background Sjogren syndrome (SS) is a chronic systemic autoimmune disease and its pathogenesis often involves the participation of numerous immune cells and inflammatory factors. …”
Get full text

Breg Cells in Celiac Disease Isolated or Associated to Hashimoto’s Thyroiditis by Maria Giulia Santaguida, Ilenia Gatto, Giorgio Mangino, Camilla Virili, Ilaria Stramazzo, Poupak Fallahi, Alessandro Antonelli, Patrizia Gargiulo, Giovanna Romeo, Marco Centanni

“…The behavior of Th17 subset in patients with celiac disease associated with HT might have been sensitive to the effect of long-lasting GFD, and it is essentially determined by the presence of thyroid autoimmunity.…”
Get full text