Dual-release hydrocortisone treatment improves serum and peripheral blood mononuclear cell inflammatory and immune profiles in patients with autoimmune primary adrenal insufficiency by Laura Tomasello, Antonina Coppola, Giuseppe Pizzolanti, Giuseppe Pizzolanti, Carla Giordano, Giorgio Arnaldi, Valentina Guarnotta

“…ObjectiveThe primary outcome was the evaluation of the T-cell phenotype in autoimmune primary adrenal insufficiency (PAI). Secondary outcomes included the evaluation of the CD4+CD25+Foxp3+ Treg population and the gene expression levels of IL-6, IL-17A, cyclooxygenase (COX)-2, heat shock proteins (HSP)-70, indoleamine-2,3-dioxygenase (IDO), programmed death-ligand 1 (PD-L1), inducible nitric oxide synthase (iNOS), and thioredoxin (TXN)-1.MethodsWe prospectively included 15 patients with PAI on conventional glucocorticoid (GC) replacement therapy, 15 switched to dual-release hydrocortisone (DR-HC), and 20 healthy controls. …”
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Reversal and prevention of deregulated autophagy in cutaneous autoimmune disorders—a pilot study on vitiligo with nutrigenomics based approach of “Maximum Nutrition and Minimum Medication” by Suruchi Garg, Murlidhar Rajagopalan, Anupa Mary George, Hemangi Parwani, Titiksha Hans

Subjects: “…autoimmune diseases…”
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Th17/Treg balance is regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides via the microbiota-gut-brain axis by Jinyun Ma, Xiaojun Liu, Yan Zhao, Qijin Lu, Guiqing Ding, Yuanhua Wang, Xiaodong Cheng

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Association of Autoimmune Thyroid Disease with Anti-GAD Antibody ELISA Test Positivity and Risk for Insulin Deficiency in Slowly Progressive Type 1 Diabetes by Masahito Katahira, Hidetada Ogata, Takahiro Ito, Tsutomu Miwata, Megumi Goto, Shizuka Nakamura, Hiromi Takashima

“…Sixty patients with SPT1D and 154 patients with type 2 diabetes were examined by both GADA-RIA and GADA-ELISA and for the presence of autoimmune thyroid disease (AITD). We compared the clinical characteristics of these patients based on the positivity or negativity of GADA-RIA and GADA-ELISA, and the existence or nonexistence of AITD. …”
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Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis by Xue Zhang, Ruli Ge, Hongliang Chen, Maxwell Ahiafor, Bin Liu, Jinbo Chen, Xueli Fan

“…Multiple sclerosis (MS) is a severe autoimmune disease that affects the central nervous system and results in disability, mediated by autoreactive T cells with evolving evidence of a remarkable contribution from humoral responses. …”
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Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis by Mónica Kurte, Javiera Bravo-Alegría, Alexander Torres, Vania Carrasco, Cristina Ibáñez, Ana María Vega-Letter, Catalina Fernández-O’Ryan, Carlos E. Irarrázabal, Fernando E. Figueroa, Rodrigo A. Fuentealba, Claudia Riedel, Flavio Carrión

“…Potent immunosuppressive and regenerative properties of mesenchymal stem cells (MSCs) position them as a novel therapy for autoimmune diseases. This research examines the therapeutic effect of MSCs administration at different disease stages in experimental autoimmune encephalomyelitis (EAE). …”
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IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury by Liwu Zeng, Yaxin Wang, Yongzhou Huang, Wenchang Yang, Pei Zhou, Yaqi Wan, Kaixiong Tao, Ruidong Li

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Systemic Lupus Erythematosus with Concurrent Thrombotic Thrombocytopenic Purpura: A Case Report of Diagnostic Challenges and Management Approaches by Sonu Rahul Tej Gaddam, Manideep Katta, Sumana Simarla, Pruthvi Raj Kukunoor, Manichandana Katta

Subjects: “…autoimmune disease…”
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Vitiligo Review: etiopathogenesis, diagnosis and treatment by Aleksandra Witek, Jakub Parys, Agnieszka Mikosińska, Martyna Kaźmierczak, Maciej Mossakowski, Patrycja Kałuziak, Marta Jajczak, Mateusz Litwin, Stanisław Jesionek, RAfał Bieś

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The Role of Childhood Traumas in Adult Hashimoto’s Thyroiditis by Uğur Aydoğan, Hüseyin Demirci, Ebru Aydoğan

Subjects: “…autoimmune thyroiditis…”
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Definition of clinical immunology around the globe by José C. Crispín, José C. Crispín, José C. Crispín, Tineke Cantaert, Tineke Cantaert, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Domenico Mavilio, Domenico Mavilio, Domenico Mavilio, Ahmed Seri, Ahmed Seri, Pierre Miossec, Pierre Miossec

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High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja by Ernesto Maddaloni, Giovanlorenzo Pastore, Marco Giuseppe Del Buono, Aldostefano Porcari, Mario Fittipaldi, Francesco Garilli, Claudio Tiberti, Silvia Angeletti, Paolo Pozzilli, Giovanni Mottini, Nicola Napoli

“…Accordingly, we found a high prevalence of autoimmune diabetes as 12% of people with diabetes showed positivity for the autoantibody against glutamic acid decarboxylase. …”
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Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies by Zhujun Mei, Zhujun Mei, Zhujun Mei, Zhujun Mei, Jingguo Wang, Jingguo Wang, Junling Wang, Xiaoni Liu, Xiaoni Liu, Bo Deng, Bo Deng, Wenbo Yang, Wenbo Yang, Xiang Zhang, Xiang Zhang, Xiangjun Chen, Xiangjun Chen, Hai Yu, Hai Yu

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Alcohol intake exacerbates experimental autoimmune prostatitis through activating PI3K/AKT/mTOR pathway-mediated Th1 differentiation by Shun Xu, Shun Xu, Shun Xu, Jing Chen, Jing Chen, Jing Chen, Shaoyu Yue, Shaoyu Yue, Shaoyu Yue, Yifan Zhang, Yifan Zhang, Yifan Zhang, Shengyu Zhao, Shengyu Zhao, Shengyu Zhao, Yongtao Hu, Yongtao Hu, Yongtao Hu, Cheng Zhang, Cheng Zhang, Cheng Zhang, Wenrui Guan, Wenrui Guan, Wenrui Guan, Li Zhang, Li Zhang, Li Zhang, Ligang Zhang, Ligang Zhang, Ligang Zhang, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

“…This research aimed to investigate the impact of alcohol on CP/CPPS using an animal model and to elucidate the underlying mechanisms.MethodsWe first established the widely used animal model for CP/CPPS, experimental autoimmune prostatitis (EAP). During the induction of EAP, mice were fed with alcohol or control diet. …”
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Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia by Fahd A. Kuriri, Abdulrahman Ahmed, Fehaid Alanazi, Fahad Alhumud, Mohammed Ageeli Hakami, Osama Atiatalla Babiker Ahmed

“…Blood transfusion-related alloimmunization and autoimmunization compromise the proper management of chronically transfused patients. …”
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Humoral Autoimmune Responses to Insulin-Like Growth Factor II mRNA-Binding Proteins IMP1 and p62/IMP2 in Ovarian Cancer by Xinxin Liu, Hua Ye, Liuxia Li, Wenjie Li, Yi Zhang, Jian-Ying Zhang

“…Our preliminary data suggest that IMP1 and p62/IMP2 can stimulate autoimmune responses in ovarian cancer, and anti-IMP1 and anti-p62/IMP2 autoantibodies could be used as potential biomarkers in immunodiagnosis of ovarian cancer.…”
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Molecular dynamics simulation of wild and mutant proteasome subunit beta type 8 (PSMB8) protein: Implications for restoration of inflammation in experimental autoimmune encephalomyelitis pathogenesis by Shamrat Kumar Paul, Md Saddam, Nisat Tabassum, Mahbub Hasan

Subjects: “…Experimental autoimmune encephalomyelitis…”
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Factors Affecting Health-Related Quality of Life and Physical Activity after Liver Transplantation for Autoimmune and Nonautoimmune Liver Diseases: A Prospective, Single Centre Study by Katarzyna Kotarska, Ewa Wunsch, Agnieszka Kempińska-Podhorodecka, Joanna Raszeja-Wyszomirska, Dimitrios P. Bogdanos, Maciej Wójcicki, Piotr Milkiewicz

“…We prospectively assessed these parameters in patients with autoimmune and nonautoimmune liver disorders undergoing LTx. …”
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Is the Increase in Tumour Markers and Hashimoto’s Thyroiditis an Incidental Event During Dupilumab Treatment? A Case Report by Kesheng Lin, Weijie Shen, Nailiang Lin, Sijia Li, Liming Wu

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Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature by Julia Nowak, Agnieszka Najdek, Daria Oleksy, Dawid Komada, Urszula Kaczmarska, Aleksandra Woźniak, Michał Jakub Cioch, Marcin Mycyk, Kamil Hermanowicz, Katarzyna Doman

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