The Role of Childhood Traumas in Adult Hashimoto’s Thyroiditis by Uğur Aydoğan, Hüseyin Demirci, Ebru Aydoğan

“…There are studies suggesting that childhood traumas cause hypothalamic-pituitary-adrenal axis dysfunction in adulthood, which predisposes patients to autoimmune diseases. Our study aimed to investigate the relationship between HT and childhood trauma. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

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Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel F-Folate Radiotracer by Adrienne Müller, Katharina Beck, Zoran Rancic, Cristina Müller, Cindy R. Fischer, Thomas Betzel, Philipp A. Kaufmann, Roger Schibli, Stefanie D. Kramer, Simon M. Ametamey

“…Folate receptor β (FR-β) is overexpressed on activated, but not resting, macrophages involved in a variety of inflammatory and autoimmune diseases. A pivotal step in atherogenesis is the subendothelial accumulation of macrophages. …”
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The Regulation between CD4+CXCR5+ Follicular Helper T (Tfh) Cells and CD19+CD24hiCD38hi Regulatory B (Breg) Cells in Gastric Cancer by Ying Zhang, Jun Wu, Haibo Zhang, Chen Wu

“…T follicular helper (Tfh) cells and regulatory B (Breg) cells are reported to play essential roles in humoral immunity, especially in inflammation, autoimmune diseases, and cancer. Hence, we sought to investigate the involvement of CXCR5+CD4+ Tfh cells and CD19+CD24hiCD38hi Breg cells in gastric cancer. …”
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Natural regulatory T cells increase significantly in pediatric patients with parasitic infections: Flow cytometry study by Nadeem Kizilbash, Nida Suhail, A. Khuzaim Alzahrani, W. Jamith Basha, Mohamed Soliman

“…The Tregs maintain tolerance to self-antigens and prevent autoimmune diseases. Aim: The purpose of this study was to determine the difference in natural Treg levels in Entamoeba histolytica, Schistosoma mansoni, Giardia lamblia, Enterobius vermicularis, and Hymenolepis nana infected patients. …”
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Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation by Fenglin Zhu, Miao Wang, Xuhong Zhang, Guoqing Zhao, Hongyan Gao, Lamei Zhou

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Association of CD24, CD27, and co-stimulatory molecules CD80 immunological marker expression on B-cells of human peripheral blood with development of celiac disease by Rahab Abd-Ali Al-Madany, Noor Abdulameer Oudah

“…Changes in the expression of these markers are linked to the development of many diseases, including chronic inflammation, autoimmune diseases, and immunodeficiency. OBJECTIVE: The current study aimed to investigate a change in CD24, CD27, and co-stimulatory molecules CD80 expression on peripheral blood B-cells and the extent of their contribution to celiac disease. …”
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Pituitary Stalk Germ Cell Tumors: Retrospective Case Series and Literature Review by Han Chen, Ming Ni, Yun Xu, Li-Yong Zhong

“…The causes of the delayed diagnosis of previous studies were mainly negative tumor markers and the initial pathological diagnosis of autoimmune diseases. Conclusion. Isolated pituitary stalk lesions could be a signal of intracranial germ cell tumors, especially coexisting with diabetes insipidus, hypopituitarism, and a worse response to glucocorticoid therapy. …”
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Hep-2000 indirect immunofluorescence assay – An emerging screening tool for detection of antinuclear autoantibodies in various connective tissue disorders by Arpita Singh, Shilpi Sahu, Neha R. Jadhav, Navdeep Kaur

“…Antinuclear Antibodies (ANA) directed against a variety of nuclear antigens detectable in the serum are used for screening, diagnoses, and monitoring of autoimmune diseases, with immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) being the most widely used methods. …”
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Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility by Yu-die Fang, Jing Zhao, Xin-juan Zhuang, Jian-bin Xu, Tian-tian Cai, Xiao-rong Yang, Kai-da Mu, Jin-an Zhang

“…Recent studies have shown that Ankyrin Repeat Domain 55 (ANKRD55) gene polymorphism is a risk factor for multiple autoimmune diseases, but its association with autoimmune thyroid diseases (AITDs) has not been reported. …”
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Diagnosing and Treating ANCA-Associated Vasculitis within the COVID-19 Era: A Challenging Case Report by Erjola Likaj, Larisa Shehaj, Deniona Nunci, Lordian Nunci, Irda Rrugeja, Merita Rroji, Saimir Seferi, Nertila Gjonaj, Alma Idrizi, Arjana Strakosha

“…Introduction: Anti-neutrophil cytoplasmic antibody (ANCA)- associated vasculitis (AAV) is a rare group of systemic autoimmune diseases that primarily target small blood vessels. …”
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Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function by Per Anderson, Elena Gonzalez-Rey, Francisco O’Valle, Francisco Martin, F. Javier Oliver, Mario Delgado

“…Multipotent mesenchymal stromal cells (MSCs) have emerged as a promising therapy for autoimmune diseases, including multiple sclerosis (MS). …”
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Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases by Tanvir Zaman Shoyshob, Sumaya Akter, Muhammad Ramiz Uddin, Mithila Farjana, Akhi Moni, Wonhyo Seo, Md. Golzar Hossain, Md Jamal Uddin

“…Currently, liver diseases have become a serious global health issue, and this situation occurs due to the exposure of the liver to different agents, such as chemicals, alcohol, viruses, and autoimmune diseases. Mangiferin is a natural bioactive xanthone C-glycoside compound and a potent antioxidant that is widely found in medicinal plants such as the leaves of Mangifera indica L. …”
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Portuguese consensus on first line treatment of moderate-to-severe psoriasis with a non-TNF inhibitor therapy – a delphi methodology by Tiago Torres, Sofia Magina, Maria João Paiva Lopes

“…Patients with infection risk, mild heart failure and associated comorbidities, autoimmune diseases and family history of demyelinating disease consensually benefit from starting non-TNFi therapy in 1 L. …”
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Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients by K. Morawska, M. Maciejczyk, S. Zięba, Ł. Popławski, A. Kita-Popławska, J. Krętowski, A. Zalewska

“…Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases. It is suggested that, in addition to thyroid gland dysfunction, HT is responsible for impaired secretion from the salivary glands. …”
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DLBWE-Cys: a deep-learning-based tool for identifying cysteine S-carboxyethylation sites using binary-weight encoding by Zhengtao Luo, Zhengtao Luo, Zhengtao Luo, Qingyong Wang, Qingyong Wang, Qingyong Wang, Yingchun Xia, Yingchun Xia, Yingchun Xia, Xiaolei Zhu, Xiaolei Zhu, Xiaolei Zhu, Shuai Yang, Shuai Yang, Shuai Yang, Zhaochun Xu, Zhaochun Xu, Lichuan Gu, Lichuan Gu, Lichuan Gu

“…Cysteine S-carboxyethylation, a novel post-translational modification (PTM), plays a critical role in the pathogenesis of autoimmune diseases, particularly ankylosing spondylitis. …”
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Successful treatment with efgartigimod as an add-on therapy for acute attack of anti-NMDA receptor encephalitis: a case report by Huasheng Huang, Yizhi Wei, Huihui Qin, Guangshun Han, Jie Li

“…Efgartigimod has demonstrated potential efficacy in the treatment of various IgG-mediated autoimmune diseases. Nonetheless, to date, no studies have investigated the use of efgartigimod in the treatment of anti-NMDAR encephalitis. …”
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Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study by Chunran Xue, Haojun Yu, Xuzhong Pei, Xiaoying Yao, Jie Ding, Xiying Wang, Yi Chen, Yangtai Guan

“…Abstract Background Human umbilical cord mesenchymal stem cells (hUC-MSCs) have great potential for treating autoimmune diseases for their immunomodulatory and tissue-regenerative abilities; however, their therapeutic role in neuromyelitis optica spectrum disorder (NMOSD) remains uncertain. …”
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Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies by Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Aleksandra Klimowicz, Michał Kloska, Dorota Mańkowska-Wierzbicka, Jerzy Sowiński, Marek Ruchała

“…Exclusion criteria consisted of other autoimmune diseases, active neoplastic disease, diabetes mellitus, and infection, which were reported to alter visfatin level. …”
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Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux by Mélanie R. Tardif, Julie Andrea Chapeton-Montes, Alma Posvandzic, Nathalie Pagé, Caroline Gilbert, Philippe A. Tessier

“…S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases. These cytoplasmic proteins are secreted by neutrophils at sites of inflammation via alternative secretion pathways of which little is known. …”
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